Clinical Outcome Of Corona Virus Disease-19 Patients In An Infectious Disease Center, Olodo, Ibadan, Oyo State, Nigeria

Alonge, Oluwagbenga

doi:10.52845/cmi/2022-3-2-2

Cited by 3 publications

(6 citation statements)

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“…A treatment protocol designed by the Case Management Team of the Oyo State COVID-19 Task Force was adopted. 13 The protocol included treating with a cocktail of chloroquine or hydroxychloroquine, zinc, vitamins C and D and or antibiotic(s) as indicated. Physiotherapy and nutritional support for these patients were also considered as priority.…”

Section: Methodsmentioning

confidence: 99%

“…[6][7][8][9][10][11] SARS-CoV-2 exhibits clinical characteristics ranging from asymptomatic to severe acute respiratory dis-tress syndrome, septic shock, and/or multiple organ dysfunctions, leading to death. 12,13 Specific treatment for COVID-19 is not known but many therapeutic strategies involved the use of anti-inflammatory-, antiprotozoan-, antioxidant-agents, antibiotics, moderate exercises and protein rich diets. [13][14][15][16] This study predicted that repurposed treatment adopted in our IDC would reduce the cytokine storm and improve the clinical indices of patients with COVID-19.…”

Section: Introductionmentioning

confidence: 99%

“…12,13 Specific treatment for COVID-19 is not known but many therapeutic strategies involved the use of anti-inflammatory-, antiprotozoan-, antioxidant-agents, antibiotics, moderate exercises and protein rich diets. [13][14][15][16] This study predicted that repurposed treatment adopted in our IDC would reduce the cytokine storm and improve the clinical indices of patients with COVID-19. However, because of limited resources and unavailability of data from hospitalised patients at admission and discharge in Nigeria, it was difficult to ascertain the effectivenss of prescribed repurposed treatment (a process of identifying new therapeutic use(s) for old/existing/available drugs) in our setting.…”

Section: Introductionmentioning

confidence: 99%

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Serum levels of IFN-γ and IL-4 in hospitalised COVID-19 patients – evidence of reduced cytokine storm in discharged patients

Arinola,

Onifade,

Adigun

et al. 2023

Eur J Clin Exp Med

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Introduction and aim. Coronavirus disease 2019 is characterised by cytokine storm and it was managed with repurposed drugs, however the effect of this treatment on cytokine storm is unknown. The aim of the study was to investigate the effect of repurposed management on serum Th1 pro-inflammation cytokine (IFN-γ) and Th2 anti-inflammation cytokine (IL-4) in COVID-19 patients. Material and methods. The levels of IFN-γ and IL-4 were determined in sera from 45 COVID-19 patients at admission followed-up till discharge after repurposed treatment using ELISA. The mean levels and proportions above normal reference ranges of IFN-γ and IL-4 were compared in COVID-19 at admission and discharge. Results. The mean values of IFN-γ and IL-4 were significantly higher in COVID-19 patients at admission compared with discharged COVID-19 patients whereas IFN-γ:IL-4 ratio was significantly higher in discharged COVID-19 patients compared with admitted COVID-19 patients. Significantly higher proportion of COVID-19 patients at discharge had IFN-γ within the normal reference ranges compared with COVID-19 patients at admission whereas the proportions of COVID-19 patients at discharge and COVID-19 patients at admission having IL-4 within the normal reference ranges were the same. Conclusion. Cytokine storm was evidenced in COVID-19 patients at admission and repurposed treatment suppressed pro-inflammation cytokine (IFN-γ) in most discharged COVID-19 patients.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum levels of IFN-γ and IL-4 in hospitalised COVID-19 patients – evidence of reduced cytokine storm in discharged patients

Arinola,

Onifade,

Adigun

et al. 2023

Eur J Clin Exp Med

View full text Add to dashboard Cite

show abstract

“…Moreso, repurposed medication used for COVID-19 patients at IDC, Ibadan, Nigeria are combinations of vitamin D, vitamin C, Zn, azithromycin, hydroxychloroquine and chloroquine (as an alternative to hydroxychloroquine). 14,[16][17][18][19][20] The treatment options for COVID-19 at this center are largely supportive as there is no universally agreed protocol of care. In addition, these medications were not used in the context of a trial but the positive outcomes encouraged their continued use.…”

Section: Introductionmentioning

confidence: 99%

“…However, it was reported that despite patient's toleration of these medications without a risk of bacterial and malarial super-infection, there is need for further evaluation. 20 However, Arinola and Edem emphasised the need for public enlightenment on the dangers inherent in micronutrient supplement abuse. 21…”

Section: Introductionmentioning

confidence: 99%

Haematological changes and metabolic alterations in SARS-CoV-2 infected patients hospitalised at an Infectious Diseases Center, Ibadan, Nigeria

Alonge¹,

Arinola²

2022

Eur J Clin Exp Med

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Introduction and aim. Following the use of repurposing drugs to successfully manage coronavirus disease 2019 (COVID-19) patients in an Infectious Diseases Center (IDC) in Nigeria, it was imperative to assess haematological changes and metabolic alterations in these patients which may inform recommendations for future use. Material and methods. Blood samples of admitted COVID-19 Nigerian patients during therapeutic management were analysed for haematological- (total white blood cells (WBC), lymphocyte, monocyte, neutrophil, eosinophil, basophil and neutrophil: lymphocyte ratio) and blood chemistry- parameters [total protein, total and conjugated bilirubin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transaminase (ALT), gamma-glutamyl transferase (GGT), albumin, urea, creatinine, total cholesterol, triglycerides, low-density lipoprotein (LDL), high-density lipoprotein (HDL), PO4 3-, Ca2+, uric acid, Na+, K+, Cl- and HCO3 -] using autoanalysers. The percentages of patients having values below, within and above reference ranges were compared using Chi-square test while the mean values at admission were compared with mean values at discharge using Student t-test. Results. The mean values of total protein, albumin, Na+, HCO3 -, uric acid, Ca2+, WBC, platelets, lymphocytes, eosinophils and basophils were significantly increased in COVID-19 patients at discharge compared with COVID-19 patients at admission. Also, more percentages of COVID-19 patients at discharge compared with COVID-19 patients at admission had albumin, ALP, total bilirubin, HDL, Na+, K+, Cl-, HCO3 -, urea, creatinine, WBC, lymphocytes, neutrophils, monocytes, eosinophils and basophils within normal reference intervals. Conclusion. This study showed that most metabolic and haematological derangements were normalised by repurposing drugs in most of the COVID-19 patients at this IDC, thus supporting the continuous use of this therapeutic option.

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Psychological Impact of Covid-19 Surge among Healthcare Workers in Primary, Secondary and Tertiary Care Settings in Cross River State, Nigeria

P.A.¹,

E.C.²

2022

African Journal of Health, Nursing and Midwifery

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Introduction: This study investigates the psychological impact of COVID-19 surge and the community spread among healthcare workers (HCWs) in the three tiers of health care delivery system in CRS. Materials and Methods: Descriptive cross-sectional design was adopted for this study. Total population sampling technique guided the recruitment of 776 consenting healthcare workers from one tertiary, one secondary and three randomly selected primary healthcare centres in the state. A well validated researcher developed, adapted and modified 21-item Depression, Anxiety and Stress Scale (DASS-21) online questionnaire with a Cronbach’s alpha coefficient reliability of 0.76, used for data collection. Result: Majority of the respondents were nurses 460 (63.3%) and the mean age was 37.3. The incidence of depression, anxiety, stress and overall psychological problems were 288 (37.1%), 375 (48.3%) 316 (40.7%) and 402 (51.8%). The overall psychological problems were higher in females 331 (58.0%) than in males 71 (34.6%) (PR=1.67). Compared with HCWs who do not have personal contact with patients, HCWs who have personal contact with patients had a higher prevalence of psychological problems (PR=1.83). Conclusion: COVID-19 pandemic has negative psychological impacts on HCWs, and having a pre-existing medical condition increases the risk of impact. Word count: 194 words

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Clinical Outcome Of Corona Virus Disease-19 Patients In An Infectious Disease Center, Olodo, Ibadan, Oyo State, Nigeria

Cited by 3 publications

References 0 publications

Serum levels of IFN-γ and IL-4 in hospitalised COVID-19 patients – evidence of reduced cytokine storm in discharged patients

Serum levels of IFN-γ and IL-4 in hospitalised COVID-19 patients – evidence of reduced cytokine storm in discharged patients

Haematological changes and metabolic alterations in SARS-CoV-2 infected patients hospitalised at an Infectious Diseases Center, Ibadan, Nigeria

Psychological Impact of Covid-19 Surge among Healthcare Workers in Primary, Secondary and Tertiary Care Settings in Cross River State, Nigeria

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