Clinical outcome of cystic fibrosis patients colonized by <i>Scedosporium</i> species following lung transplantation: A single‐center 15‐year experience

Parize, Perrine; Boussaud, V.; Poinsignon, Vianney; Sitterlé, Emilie; Botterel, Françoise; Lefeuvre, Sandrine; Guillemain, R.; Dannaoui, Éric; Billaud, Éliane

doi:10.1111/tid.12738

Cited by 31 publications

(17 citation statements)

References 52 publications

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“…Infection with certain microorganisms (e.g. Burkholderia cepacia complex, nontuberculous mycobacterium, molds such as scedosporium, multi-drug resistant or increasingly resistant microorganisms) is associated with worse outcomes following lung transplantation [18,61,[84][85][86][87][88][89]. These microorganisms may be considered absolute contraindications at some transplant programs and acceptable at others While there are established international consensus recommendations for the selection of lung transplant candidates, published by the ISHLT [61], each lung transplant program has developed its own specific criteria for transplant candidacy and listing.…”

Section: The Cf Foundation Recommends Cf Clinician Consultation Withmentioning

confidence: 99%

Lung transplant referral for individuals with cystic fibrosis: Cystic Fibrosis Foundation consensus guidelines

Ramos

Smith

McKone

et al. 2019

Journal of Cystic Fibrosis

185

145

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Objective: Provide recommendations to the cystic fibrosis (CF) community to facilitate timely referral for lung transplantation for individuals with CF. Methods: The CF Foundation organized a multidisciplinary committee to develop CF Lung Transplant Referral Consensus Guidelines. Three workgroups were formed: timing for transplant referral; modifiable barriers to transplant; and transition to transplant care. A focus group of lung transplant recipients with CF and spouses of CF recipients informed guideline development. Results: The committee formulated 21 recommendation statements based on literature review, committee member practices, focus group insights, and in response to public comment. Critical approaches to optimizing access to lung transplant include early discussion of this treatment option, assessment for modifiable barriers to transplant, and open communication between the CF and lung transplant centers. Conclusions: These guidelines will help CF providers counsel their patients and may reduce the number of individuals with CF who die without consideration for lung transplant.

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Section: The Cf Foundation Recommends Cf Clinician Consultation Withmentioning

confidence: 99%

Lung transplant referral for individuals with cystic fibrosis: Cystic Fibrosis Foundation consensus guidelines

Ramos

Smith

McKone

et al. 2019

Journal of Cystic Fibrosis

185

145

View full text Add to dashboard Cite

show abstract

“…In addition, the presence of Aspergillus spp. in the same sample could also hamper the growth of S/L . In a monocentric Australian study including 59 colonized patients, S/L were found in association with Aspergillus sp in 29% of cases .…”

Section: Discussionmentioning

confidence: 98%

Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation: Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology

Rammaert

Puyade

Cornely³

et al. 2019

Transplant Infectious Dis

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Background: Scedosporium species and Lomentospora prolificans (S/L) are the second most common causes of invasive mold infections following Aspergillus in lung transplant recipients. Methods: We assessed the current practices on management of S/L colonization/infection of the lower respiratory tract before and after lung transplantation in a large number of lung transplant centers through an international practice survey from October 2016 to March 2017. S/L in the past 5 years. Conclusions: This survey gives an overview of the current practices regarding S/L colonization and infection in lung transplant centers worldwide and underscores the need of S/L culture procedure standardization before implementing prospective studies.

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“…However, a recent study in the era of mold-active triazole prophylaxis suggests outcomes may be favorable for patients with S. apiospermum species complex colonization. 27 Among eight CF patients colonized with S. apiospermum species complex prior to transplant, none developed invasive Scedosporium infection posttransplant and seven survived more than 1-year posttransplant (provisional median survival 1.9 years, range 0.2-12.5). Four patients became free of S. apiospermum species complex colonization immediately posttransplant and another three patients within 1 year.…”

Section: Clinical Manifestationsmentioning

confidence: 94%

Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

Jacobs

Wengenack

Walsh

2020

Semin Respir Crit Care Med

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Hyaline molds, widely distributed in nature, are an important and increasing cause of invasive fungal infections in humans, likely due to an expanding population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics. Sinopulmonary disease and disseminated infection are common manifestations in neutropenic patients and transplant recipients, whereas, catheter-related and localized soft tissue infections predominate in immunocompetent hosts. These organisms are not reliably differentiated based on their morphology in tissue; rather, efforts should be made to establish a microbiologic diagnosis via culture or molecular-based methods to guide antifungal management and inform prognosis. Herein, we review the epidemiology, clinical manifestations, diagnosis, and management of these opportunistic pathogens known to cause hyalohyphomycoses: Scedosporium spp., Lomentospora prolificans, Fusarium spp., Scopulariopsis spp., Arthrographis kalrae, Trichoderma spp., Acremonium spp., Paecilomyces variotii, Purpureocillium lilacinum, and Penicillium species.

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Clinical outcome of cystic fibrosis patients colonized by Scedosporium species following lung transplantation: A single‐center 15‐year experience

Abstract: It appears to us that scedosporial colonization may not be a contraindication for LT in CF patients, as long as S. apiospermum complex is involved and a life-long azole prophylaxis prescribed.

Cited by 31 publications

References 52 publications

Lung transplant referral for individuals with cystic fibrosis: Cystic Fibrosis Foundation consensus guidelines

Lung transplant referral for individuals with cystic fibrosis: Cystic Fibrosis Foundation consensus guidelines

Perspectives on Scedosporium species and Lomentospora prolificans in lung transplantation: Results of an international practice survey from ESCMID fungal infection study group and study group for infections in compromised hosts, and European Confederation of Medical Mycology

Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

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