Clinical outcome of exclusive endoscopic tympanoplasty with porcine small intestine submucosa in 72 patients

Chen, Chin‐Kuo; Hsieh, Li‐Chun

doi:10.1111/coa.13607

Cited by 8 publications

(12 citation statements)

References 23 publications

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“…Yawn et al had a 77.3% closure rate for primary surgery with pSIS and 100% after a single revision in a group of adult and pediatric patients, the majority of whom had concomitant cartilage grafting 6 . Additionally, Chen et al similarly noted a closure rate of 94.7% with pSIS in an adult population 18 . Similarly high closure rates were found in both the pediatric and adult populations for primary isolated tympanoplasty.…”

Section: Discussionmentioning

confidence: 93%

“…The majority of patients also received a concomitant cartilage graft, which may have influenced the graft take rate 6 . Chen and Hsieh also found a high closure rate with pSIS in an adult population with TM perforation related to simple chronic otitis media 18 . Both of these studies reported significant improvement in postoperative air–bone gap (ABG) 6,18 …”

Section: Introductionmentioning

confidence: 99%

“…6 Chen and Hsieh also found a high closure rate with pSIS in an adult population with TM perforation related to simple chronic otitis media. 18 Both of these studies reported significant improvement in postoperative air-bone gap (ABG). 6,18 While Yawn and Chen reported strong audiometric data in support of pSIS, neither study included a comparison group.…”

Section: Introductionmentioning

confidence: 99%

“…18 Both of these studies reported significant improvement in postoperative air-bone gap (ABG). 6,18 While Yawn and Chen reported strong audiometric data in support of pSIS, neither study included a comparison group. D'Eredita's study was a direct comparison between pSIS and autologous fascia and found that the two groups had similar outcomes, but it was limited to a pediatric population and did not include the specific audiometric data.…”

Section: Introductionmentioning

confidence: 99%

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Anatomic and audiometric outcomes of porcine intestinal submucosa for tympanic membrane repair

Dontu

Shaigany

Eisenman

2022

Laryngoscope Investig Oto

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Objective Surgical repair of tympanic membrane perforations has been traditionally performed with autologous soft‐tissue grafts with high success rates. Newer allografts such as porcine small intestine submucosa (pSIS) have been employed as alternatives to minimize donor morbidity and surgical time, and in cases where autologous tissue may not be available. The comparative anatomic and audiometric success rates of these tissues is still unclear. Study design Retrospective case–control series of anatomic and audiometric outcomes of autologous soft tissue versus pSIS graft for primary, isolated transmeatal tympanic membrane repair. Methods Analysis of patients undergoing primary transmeatal tympanic membrane repair with autologous soft tissue or pSIS. Patients with otorrhea, cholesteatoma or retraction pockets, those who had cartilage grafts or ossicular reconstruction, and revision procedures were excluded. Pre‐ and post‐surgery air–bone gaps (ABG) and pure tone averages (PTA) were compared. Graft success was defined as closure of the perforation at 2‐month follow‐up visit. Results The success rate for both the autologous soft tissue and the pSIS arm is 93.8%. There was no statistical significance (p < .05) between the post‐op ABG, change in ABG, post‐op PTA, change in PTA, or graft success rate between the two groups with either lumped cohort or matched‐pairs analysis. Conclusions pSIS grafts are effective for repair of tympanic membrane perforations with hearing outcomes and graft success rates comparable to autologous soft tissue. Lay summary Repair of tympanic membrane perforations is traditionally done using a soft‐tissue graft harvested from the patient at the time of surgery. pSIS is a newer graft material that is equally effective in terms of anatomical and audiometric outcomes. Level of evidence Level 3b.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anatomic and audiometric outcomes of porcine intestinal submucosa for tympanic membrane repair

Dontu

Shaigany

Eisenman

2022

Laryngoscope Investig Oto

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“…Moreover, the one-handed surgical technique in particular might benefit from the more rigid grafting material, as its correct placement may be facilitated. This might also be the reason for the promising results of porcine small intestine submcosa grafting in endoscopic tympanoplasty type I with GIR of 94.7% and significant ABG improvement of 7.2 dB 24 . Further reduced donor-site morbidity and additional reduction of operation time due to graft harvesting are the considerable advantages of this method.…”

Section: Discussionmentioning

confidence: 96%

Minimally invasive tympanoplasty: review of outcomes and technical refinements

Beckmann

Anschuetz

2021

Operative Techniques in Otolaryngology-Head and Neck Surgery

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Progress of biodegradable polymer application in cardiac occluders

Xu,

Fa,

Yang

et al. 2023

J Biomed Mater Res

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Cardiac septal defect is the most prevalent congenital heart disease and is typically treated with open‐heart surgery under cardiopulmonary bypass. Since the 1990s, with the advancement of interventional techniques and minimally invasive transthoracic closure techniques, cardiac occluder implantation represented by the Amplazter products has been the preferred treatment option. Currently, most occlusion devices used in clinical settings are primarily composed of Nitinol as the skeleton. Nevertheless, long‐term follow‐up studies have revealed various complications related to metal skeletons, including hemolysis, thrombus, metal allergy, cardiac erosion, and even severe atrioventricular block. Thus, occlusion devices made of biodegradable materials have become the focus of research. Over the past two decades, several bioabsorbable cardiac occluders for ventricular septal defect and atrial septal defect have been designed and trialed on animals or humans. This review summarizes the research progress of bioabsorbable cardiac occluders, the advantages and disadvantages of different biodegradable polymers used to fabricate occluders, and discusses future research directions concerning the structures and materials of bioabsorbable cardiac occluders.

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Clinical outcome of exclusive endoscopic tympanoplasty with porcine small intestine submucosa in 72 patients

Cited by 8 publications

References 23 publications

Anatomic and audiometric outcomes of porcine intestinal submucosa for tympanic membrane repair

Anatomic and audiometric outcomes of porcine intestinal submucosa for tympanic membrane repair

Minimally invasive tympanoplasty: review of outcomes and technical refinements

Progress of biodegradable polymer application in cardiac occluders

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