Clinical Outcome of IBD-Associated versus Sporadic Colorectal Cancer: A Matched-Pair Analysis

Renz, Bernhard W.; Thasler, Wolfgang E.; Preißler, Gerhard; Heide, Tobias; Khalil, Philipe N.; Mikhailov, Michael; Jauch, Karl‐Walter; Kreis, Martin E.; Rentsch, Markus; Kleespies, Axel

doi:10.1007/s11605-013-2171-z

Cited by 33 publications

(27 citation statements)

References 32 publications

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“…Some previous studies have shown worse oncological outcomes in the UCCC patient group [8, 18, 22]. In a Japanese nationwide study, Watanabe et al assessed 121 patients who had undergone surgery for UCCC.…”

Section: Discussionmentioning

confidence: 99%

“…The negative effect of UC on the prognosis of CC was more pronounced in the first year after cancer diagnosis, in patients diagnosed with CC before the age of 70 years, in patients with UC duration of eight years or more, and in cancers with advanced or unknown stage [18]. In a recent matched pair analysis, 33 patients with inflammatory bowel disease-associated CC had a significantly reduced and markedly lower OS rate, as well as a notably increased recurrence rate, compared to sporadic CRC patients (48.6 vs. 67.1%, respectively) [22]. A single-centre retrospective study performed in 2016 compared OS and surgical technique in 27 patients with UC and rectal cancer and 54 patents with sporadic rectal cancer [14].…”

Section: Discussionmentioning

confidence: 99%

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Prognosis of ulcerative colitis colorectal cancer vs. sporadic colorectal cancer: propensity score matching analysis

et al. 2017

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BackgroundUlcerative colitis (UC) harbours a high risk of UC-associated colorectal cancer (UCCC), which is important cause of morbidity and mortality in patients with inflammatory bowel disease. Overall Survival (OS) of patients with UCCC has not been addressed well in the literature. Thus, we compared oncologic outcome of UCCC and sporadic colorectal cancer (SCC) using propensity score matching analysis.MethodsPropensity score matching was performed for 36 patients, a 1:1 matching method stratified into 18 in UCCC and 18 patients in SCC. Matched variables were sex, age, body mass index, tumour stage, histology, preoperative carcinoembryonic antigen (CEA) level, and adjuvant treatment status. Patients with SCC or UCCC were retrospectively retrieved from our database from March 2000 to December 2015. All patients had undergone either oncological segmental resection or total proctocolectomy.ResultsThe majority of cancers were found in the sigmoid colon. Total proctocolectomy was performed only in the UCCC group; however, half of the UCCC group underwent a standard operation. Five cases of postoperative complication occurred within six months in the UCCC group compared to one case in the SCC group. There was no significant difference in recurrence rate (p = 0.361) or OS (p = 0.896) between the arms.ConclusionUCCC showed more postoperative complications than SCC, and equivalent oncology outcome, however the difference was not statistically significant. This study represents an experience of a single institution, thus further randomized studies are required to confirm our.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognosis of ulcerative colitis colorectal cancer vs. sporadic colorectal cancer: propensity score matching analysis

et al. 2017

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“…Similar to our methodology, patients were matched on age, gender, tumor stage, tumor site, and date of surgery. These investigators found that IBD was independently associated with a significantly higher local tumor recurrence (30.3% vs. 10.8%, P ¼ 0.004) and significantly lower 5-year overall survival (49% vs. 67%, P ¼ 0.03) [21]. They also observed that patients with IBD had a significantly higher proportion of high-grade tumors compared to those with sporadic disease, though on further analysis this did not seem to account for the difference in local recurrence rates.…”

Section: Discussionmentioning

confidence: 96%

A matched case‐control study of IBD‐associated colorectal cancer: IBD portends worse outcome

Hrabe

Byrn

Button

et al. 2013

Journal of Surgical Oncology

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“…The prognosis of CRC has been described to be poorer in patients with IBD 10 31 . Beside a higher complication rate, significantly higher local recurrence and lower 5-year-survival rates were observed for patients with IBD-related cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the groups of Renz and Scaringi could show lower 5-year survival and higher local recurrence rates in inflammatory bowel disease (IBD)-related compared to sporadic CRC and suggest a link to the differences in tumour biology 10 11 .…”

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confidence: 99%

Establishment and characterization of HROC69 – a Crohn´s related colonic carcinoma cell line and its matched patient-derived xenograft

Kuehn¹,

Mullins

Krohn

et al. 2016

Sci Rep

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Colitis-associated colorectal cancer (CAC) seems to be a rather unique entity and differs in its genetic alterations, tumour formation capacities, and clinical features from sporadic colorectal carcinoma. Most descriptions about tumour biology of CAC refer to ulcerative colitis; data about Crohn´s colitis related carcinomas are scarce. The majority of patients with Crohn´s disease are under immunosuppression which generates a different environment for tumour growth. We first describe the clinical case of a fast growing CAC in a long-term immunosuppressed patient with Crohn´s disease and successful establishment and characterization of carcinoma cell lines along with their corresponding patient-derived xenograft. Subsequently, these tumor models were molecularly and functionally analysed. Beside numerous chromosomal alterations, mutations in TP53, APC, PTEN and SMAD3 were identified. The cell lines express numerous cancer testis antigens, surface molecules involved in immune evasion but low levels of HLA class I molecules. They show strong invasive but in comparison weak migratory activity. The present work is the first description of patient-derived in vitro and in vivo models for CAC from a Crohn´s disease patient. They might be valuable tools for analysis of genetic and epigenetic alterations, biomarker identification, functional testing, including response prediction, and the development of specific therapeutical strategies.

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Clinical Outcome of IBD-Associated versus Sporadic Colorectal Cancer: A Matched-Pair Analysis

Abstract: We demonstrate for the first time survival differences between IBD-CRC and SCRC after elimination of five known confounders. This might be caused by a difference in tumor biology resulting in a higher local recurrence rate in IBD-CRC.

Cited by 33 publications

References 32 publications

Prognosis of ulcerative colitis colorectal cancer vs. sporadic colorectal cancer: propensity score matching analysis

Prognosis of ulcerative colitis colorectal cancer vs. sporadic colorectal cancer: propensity score matching analysis

A matched case‐control study of IBD‐associated colorectal cancer: IBD portends worse outcome

Establishment and characterization of HROC69 – a Crohn´s related colonic carcinoma cell line and its matched patient-derived xenograft

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