Clinical Outcome of Kidney Transplant Patients on the Allograft Function, Loss, Effects of HLA-DQB1-DSA+, and Graft Survival

Cunha, A.P.L.; Fabreti‐Oliveira, R. A.; Lasmar, Marcus Faria; García, J Contreras; Vilela, T.P.; Nascimento, Evaldo

doi:10.1016/j.transproceed.2021.07.011

Cited by 5 publications

(3 citation statements)

References 31 publications

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“…Many factors might prevent recipients from obtaining an ideal eGFR during the perioperative period, including rejection, delayed graft function, and operative complications ( 7 , 46 , 47 ). However, the period of 3 weeks after LDKT is early to optimize immunosuppression, treat comorbidities, and detect and treat surgical complications, including graft vascular stenosis and urinary tract obstruction.…”

Section: Discussionmentioning

confidence: 99%

“…This finding enabled the detection of slightly widening disparities of eGFR after KT between the graft loss and non-graft loss groups, which could not be detected using the actual eGFR after KT. Many factors might prevent recipients from obtaining an ideal eGFR during the perioperative period, including rejection, delayed graft function, and operative complications (7,46,47). However, the period of 3 weeks after LDKT is early to optimize immunosuppression, treat comorbidities, and detect and treat surgical complications, including graft vascular stenosis and urinary tract obstruction.…”

Section: P-valuementioning

confidence: 99%

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Prediction models for the recipients’ ideal perioperative estimated glomerular filtration rates for predicting graft survival after adult living-donor kidney transplantation

Hiramitsu,

Hasegawa,

Futamura

et al. 2023

Front. Med.

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IntroductionThe impact of the perioperative estimated glomerular filtration rate (eGFR) on graft survival in kidney transplant recipients is yet to be evaluated. In this study, we developed prediction models for the ideal perioperative eGFRs in recipients.MethodsWe evaluated the impact of perioperative predicted ideal and actual eGFRs on graft survival by including 1,174 consecutive adult patients who underwent living-donor kidney transplantation (LDKT) between January 2008 and December 2020. Prediction models for the ideal perioperative eGFR were developed for 676 recipients who were randomly assigned to the training and validation sets (ratio: 7:3). The prediction models for the ideal best eGFR within 3 weeks and those at 1, 2, and 3 weeks after LDKT in 474 recipients were developed using 10-fold validation and stepwise multiple regression model analyzes. The developed prediction models were validated in 202 recipients. Finally, the impact of perioperative predicted ideal eGFRs/actual eGFRs on graft survival was investigated using Fine–Gray regression analysis.ResultsThe correlation coefficients of the predicted ideal best eGFR within 3 weeks and the predicted ideal eGFRs at 1, 2, and 3 weeks after LDKT were 0.651, 0.600, 0.598, and 0.617, respectively. Multivariate analyzes for graft loss demonstrated significant differences in the predicted ideal best eGFR/actual best eGFR within 3 weeks and the predicted ideal eGFRs/actual eGFRs at 1, 2, and 3 weeks after LDKT.DiscussionThe predicted ideal best eGFR/actual best eGFR within 3 weeks and the predicted ideal eGFRs/actual eGFRs at 1, 2, and 3 weeks after LDKT were independent prognostic factors for graft loss. Therefore, the perioperative predicted ideal eGFR/actual eGFR may be useful for predicting graft survival after adult LDKT.

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Section: Discussionmentioning

confidence: 99%

Section: P-valuementioning

confidence: 99%

Prediction models for the recipients’ ideal perioperative estimated glomerular filtration rates for predicting graft survival after adult living-donor kidney transplantation

Hiramitsu,

Hasegawa,

Futamura

et al. 2023

Front. Med.

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“…B. Cw12, Cw15, Cw17) 5 . In mehreren Studien war der Effekt von DSA, die nur gegen Cw-Merkmale oder nur gegen DQ-Merkmale gerichtet waren, vergleichbar mit dem Effekt von DSA gegen Merkmale anderer Loci 6 7 .…”

Section: Auswahl Des Geeigneten Transplantationsprogrammsunclassified

Organtransplantation – Welche spenderspezifischen HLA-Antikörper sind akzeptabel?

Ziemann

2023

Transfusionsmedizin

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HLA-Merkmale, gegen die Patienten auf der Transplantationswarteliste immunisiert sind, können als nicht-akzeptable HLA-Antigendifferenzen (NAHA) definiert werden. Bei breit immunisierten Patienten kann es schwierig sein, alle HLA-Antikörper als NAHA zu berücksichtigen, da dies die Zahl kompatibler Spender minimiert. Dieser Beitrag gibt eine Übersicht, welche Kriterien bei der Auswahl der Antikörper für die Definition von NAHA hilfreich sein können.

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The impact of pretransplant suspected HLA antibody on the long-term outcome of the graft kidney: A retrospective cohort study

Yang,

Bai,

Wang

et al. 2024

Transplant Immunology

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Clinical Outcome of Kidney Transplant Patients on the Allograft Function, Loss, Effects of HLA-DQB1-DSA+, and Graft Survival

Cited by 5 publications

References 31 publications

Prediction models for the recipients’ ideal perioperative estimated glomerular filtration rates for predicting graft survival after adult living-donor kidney transplantation

Prediction models for the recipients’ ideal perioperative estimated glomerular filtration rates for predicting graft survival after adult living-donor kidney transplantation

Organtransplantation – Welche spenderspezifischen HLA-Antikörper sind akzeptabel?

The impact of pretransplant suspected HLA antibody on the long-term outcome of the graft kidney: A retrospective cohort study

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