Clinical outcome of periodontal regenerative therapy using collagen membrane and deproteinized bovine bone mineral: a 2.5-year follow-up study

Irokawa, Daisuke; Takeuchi, Takahiro; Noda, Katsuya; Goto, H; Egawa, Masahiro; Tomita, Sachiyo; Sugito, Hiroki; Nikaido, Masahiko; Saitô, Atsushi

doi:10.1186/s13104-017-2426-y

Cited by 18 publications

(16 citation statements)

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“…In our previous study of the periodontal regenerative study using a deproteinized bovine bone mineral in combination with a collagen membrane [12], mean gain in CAL at 2.5 years was 1.4 mm, which is smaller than the 2-year value in the present study. Although it is difficult to directly compare these data, it is remarkable that the EMD therapy yielded such result without the use of any bone substitutes.…”

Section: Discussioncontrasting

confidence: 84%

Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective 2-year study

et al. 2017

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ObjectiveTo date, enamel matrix derivative (EMD) has been considered to be one of the few biomaterials for clinical use capable of demonstrating true periodontal regeneration. The aim of this two-center prospective clinical study was to evaluate 2-year outcome of periodontal regenerative therapy using EMD in the treatment of intrabony defects, performed as an ‘advanced medical treatment’ under the national healthcare system in Japan.ResultsPatients with chronic periodontitis who have completed initial periodontal therapy at either of the two dental school clinics were enrolled. Each contributed at least one intrabony defect of ≥3 mm in depth. During surgery, EMD was applied to the defect following debridement. Twenty-two participants (mean age 55.2 years old, 9 men and 13 women) completed 2-year reevaluation, and a total of 42 defects were subjected to data analysis. Mean gains in clinical attachment level (CAL) at 1 and 2 years were 2.9 mm (38% of baseline CAL) and 3.1 mm (41%), respectively, both showing a significant improvement from baseline. There was also a significant reduction in probing depth (PD): mean reductions at 1 and 2 years were 3.2 and 3.3 mm, respectively. There was a progressive improvement in the mean percentages of bone fill from 26% at 1 year to 36% at 2 years. No significant difference in CAL gain at 2 years was found between 3-wall bone defects and other defect types combined. In multiple regression analysis, the baseline PD was significantly associated with CAL gain at 2 years. In this population of patients, the treatment of intrabony defects with EMD yielded clinically favorable outcomes, as assessed by periodontal and radiographical parameters, over a period of 2 years.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-017-2572-2) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 84%

Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective 2-year study

et al. 2017

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“…Las técnicas de regeneración ósea guiada en combinación con injertos óseos pueden ser utilizadas para la reconstrucción de grandes lesiones periapicales con una elevada tasa de éxito 33 . El uso de membranas barrera impide la penetración y el contacto del tejido conectivo con las paredes del defecto óseo, permitiendo la recolonización del mismo por células propias del tejido óseo, a la vez que protege y estabiliza el coágulo sanguíneo subyacente que se ha formado 34 .…”

Section: Discussionunclassified

Tratamiento de lesión periapical con obturación retrógrada e injerto óseo. Reporte de un caso

Peñafiel¹,

Pallaroso²,

Viteri³

2019

Odontol. sanmarquina

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El objetivo de este estudio es presentar un caso en el que tras el fracaso del tratamiento endodóntico se observó una lesión quística en el periápice. El presente caso trata de una paciente femenina de 39 años de edad, sin antecedentes médicos relevantes quien asistió a la clínica odontológica SERODU, determinando a la palpación la presencia de una tumefacción de consistencia blanda que estaría afectando la integridad del tejido óseo, sin sintomatología. Las pruebas de vitalidad pulpar resultaron negativas. Al examen radiográfico se observó una sombra radiolúcida compatible con lesión periapical crónica que afecta a las piezas dentales 11 y 12. Por lo que se decidió llevar a cabo la cirugía periapical con apicectomía, sellado apical retrógrado y enucleación de la lesión quística, seguido de regeneración ósea guiada. A los tres meses de control, radiográficamente se encontró una zona radiopaca compatible con regeneración ósea con un halo radiolúcido de separación con el hueso basal original, y a los seis meses, se observó la regeneración ósea completa. La técnica de obturación retrógrada e injerto óseo constituye una técnica de tratamiento efectivo para el sellado del conducto a nivel apical y la regeneración de defectos periapicales de gran tamaño.

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“…2 15,16,24,25,27,33,35,37,46, and 47. Semi-standardized radiographs were taken using film holders with customized occlusal stents as described previously 10) . Measurements were obtained from the radiographs using the Schei Ruler Technique 20) .…”

Section: Clinical Assessment and Diagnosismentioning

confidence: 99%

Periodontal Regenerative Therapy Using Enamel Matrix Derivative for Treatment of Generalized Severe Chronic Periodontitis: A 2-year Case Report

Seshima

Kigure²,

Saitô

2019

Bull. Tokyo Dent. Coll.

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Here, we describe the treatment course and 2-year follow-up in a case of multiple deep intrabony defects treated with periodontal regenerative therapy. The patient was a 50-year-old woman presenting with the chief complaint of mobile teeth in the maxillary molar region. Examination at her initial visit revealed sites with a probing depth of ≥7 mm in the molar region. Radiographic examination revealed generalized bone resorption. Angular bony defects were evident in the molar region. Initial periodontal therapy was commenced based on a clinical diagnosis of generalized chronic periodontitis. At re-evaluation, an improvement was observed in periodontal conditions. Periodontal regenerative therapy with enamel matrix derivative was performed on teeth #13, 15, 24, 27, 33, 35, 37, 46, and 47. Following re-evaluation, a removable partial denture was used to replace teeth #26 and 45, and the patient placed under supportive periodontal therapy. Periodontal conditions have remained stable. Careful supportive periodontal therapy needs to be continued, however, to monitor and treat sites requiring further attention, including those with furcation involvement.

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Clinical outcome of periodontal regenerative therapy using collagen membrane and deproteinized bovine bone mineral: a 2.5-year follow-up study

Cited by 18 publications

References 29 publications

Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective 2-year study

Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective 2-year study

Tratamiento de lesión periapical con obturación retrógrada e injerto óseo. Reporte de un caso

Periodontal Regenerative Therapy Using Enamel Matrix Derivative for Treatment of Generalized Severe Chronic Periodontitis: A 2-year Case Report

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