Clinical outcome of planned oocyte cryopreservation at advanced age

Tsafrir, Avi; Ben‐Ami, Ido; Eldar‐Geva, Talia; Gal, M.; Dekel, Nava; Levi, H.; Schonberger, Oshrat; Srebnik, Naama; Weintraub, Amir; Goldberg, D.A.; Hyman, Jordana

doi:10.1007/s10815-022-02633-7

Cited by 12 publications

(6 citation statements)

References 29 publications

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“…We noted that out of 558 women, live births were achieved by 196 women giving an average of 35%. The age-wise distribution was comparable mainly in three studies [ 15 , 16 , 22 ]; the reason being varied age-group distribution. In total, 24/50 (48%) women achieved live birth and on-going pregnancy in the age group less than 38 years and 20/94 (21%) in the age-group 38 years or older.…”

Section: Resultsmentioning

confidence: 74%

“…Similarly, the oocyte fertilisation rate was comparable in 2 out of 10 studies [ 15 , 22 ] and the collated data from the 2 studies showed an average egg fertilisation rate of 67%. In total, 2 out of 10 quoted fertilisation rate in percentage without exact numbers, however the average percentage of fertilisation rate was similar (67%).…”

Section: Resultsmentioning

confidence: 78%

“…The collated data revealed 1006 women returned to use their eggs out of 8208, giving an average usage of 12% (Table 2). Out of 10 studies, the oocyte survival rate post thaw was quoted in 4 studies, compared with [15,22,24,27], wherein the number of eggs surviving the thaw were 82% (6462/7904).…”

Section: Results From Literature Reviewmentioning

confidence: 99%

“…Out of 10 studies, the oocyte survival rate post thaw was quoted in 4 studies, compared with [ 15 , 22 , 24 , 27 ], wherein the number of eggs surviving the thaw were 82% (6462/7904).…”

Section: Resultsmentioning

confidence: 99%

“…To date, studies reporting outcomes in women returning to use their cryopreserved oocytes after social egg freezing are scarce [ 14 , 15 , 16 ]. Hence, we conducted this study with an objective to evaluate the outcomes of egg thaw at Guy’s Hospital, following social egg freezing and to compare our results with a comprehensive literature review of published data in order to provide evidence-based contemporaneous information to help women make an informed decision when planning to embark on social egg freezing.…”

Section: Introductionmentioning

confidence: 99%

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Outcomes of Social Egg Freezing: A Cohort Study and a Comprehensive Literature Review

Kakkar,

Geary,

Stockburger

et al. 2023

JCM

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The purpose of this study is to evaluate the live birth outcome following oocyte thaw in women who underwent social egg freezing at Guy’s Hospital, alongside a detailed published literature review to compare published results with the current study. A retrospective cohort study was conducted between January 2016 and March 2022 for all women who underwent egg freezing during this period. Overall, 167 women had 184 social egg freezing cycles. The mean age at freeze was 37.1 years and an average of 9.5 eggs were frozen per retrieval. In total, 16% of the women returned to use their frozen eggs. The mean egg thaw survival rate post egg thaw was 74%. The mean egg fertilisation rate was 67%. The pregnancy rate achieved per embryo transfer was 48% and the live birth rate per embryo transfer was 35%. We also noted that irrespective of age at freezing, a significantly high live birth rate was achieved when the number of eggs frozen per patient was 15 or more. Despite the rapid increase in social egg freezing cycles, the utilisation rate remains low. Pregnancy and live birth rate post thaw are encouraging if eggs are frozen at a younger age and if 15 eggs or more were frozen per patient.

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Section: Resultsmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 78%

Section: Results From Literature Reviewmentioning

confidence: 99%

“…Out of 10 studies, the oocyte survival rate post thaw was quoted in 4 studies, compared with [ 15 , 22 , 24 , 27 ], wherein the number of eggs surviving the thaw were 82% (6462/7904).…”

Section: Resultsmentioning

confidence: 99%