Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients

Han, Hyouk Soo; Kim, Ju Ree; Nam, Hae Yun; Keum, Ki Chang; Suh, Chang Ok; Kim, Yong Bae

doi:10.3857/roj.2014.32.3.132

Cited by 7 publications

(2 citation statements)

References 18 publications

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“… 26 Second, we evaluated pT1–2NxM0 patients, not all breast cancer patients. 27 Thus, our cohorts do not represent all breast cancer patients and need an external validation for the integrity. However, we enrolled 367 consecutive breast cancer patients with pT1–2NxM0 and evaluated them for several molecular markers to assess the exact association between molecular markers and clinical factors and the presence of ALNM.…”

Section: Discussionmentioning

confidence: 99%

Simple Prediction Model of Axillary Lymph Node Positivity After Analyzing Molecular and Clinical Factors in Early Breast Cancer

Chung

Lee²,

Kim³

et al. 2016

Medicine

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The aim of this study was to evaluate the association between pretreatment molecular and clinical factors and axillary lymph node metastases in early breast cancer. A total of 367 consecutive breast cancer patients with cT1–2NxM0 who underwent breast conserving surgery and axillary lymph node dissection followed by whole breast irradiation were enrolled. We evaluated the pathologic tumor and node status, tumor differentiation, calcification, and lymphovascular invasion, the status of estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor 1 (EGFR1), and human epidermal growth factor receptor 2 (HER2), the expression of E-cadherin, P53, and Ki-67 index. Totally, 108 (29.4%) of the 367 patients had positive axillary lymph nodes. An increased tumor size (P = 0.024), the presence of lymphovascular invasion (P < 0.001), and Ki-67 index of >20% (P = 0.038) were significantly associated with axillary lymph node metastases on the multivariate analysis. In our study, 86.2% of the patients with all the unfavorable factors had an involvement of axillary nodal metastases, and only 12.2% of the patients with all the favorable predictors had positive axillary nodes. The predictive power was significant on the receiver operating curve (P < 0.001). We found that several factors, such as tumor size, lymphovascular invasion, and the Ki-67 index, are independent factors that predict positive ALNM on multivariate analysis for the patients with cT1–2 breast cancer. Clinicians simply could predict the probability of ALNM after verifying the molecular and clinical factors in early breast cancer.

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Section: Discussionmentioning

confidence: 99%

Simple Prediction Model of Axillary Lymph Node Positivity After Analyzing Molecular and Clinical Factors in Early Breast Cancer

Chung

Lee²,

Kim³

et al. 2016

Medicine

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“…A lymphoscintigram was obtained to identify all basins at risk and the sentinel LN. In the operating room, a hand-held gamma detector (Navigator GPS, RMD Inc., Watertown, MA, USA) was used to identify sentinel LNs [ 11 ]. After the sentinel LN was harvested and measured again for radioactivity, the probe was used to search the harvested area to ensure there were no residual nodes with significant radioactivity.…”

Section: Methodsmentioning

confidence: 99%

Complications and outcomes following inguinal lymphadenectomy for malignant melanoma in an Asian population

Lee

Kim

et al. 2020

Korean J Clin Oncol

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Purpose: Melanoma is a potentially fatal cutaneous malignancy and regional lymph node (LN) metastases are the most important predictors of mortality. This study aimed to analyze clinical features and risk factors of complications associated with inguinal LN dissection (LND) to establish treatment protocols. Methods: This single-center retrospective study (2000 to 2018) consisted of patients who underwent inguinal area sentinel LN biopsy (SLNB) or LND due to malignant melanoma. Risk factors and outcomes were analyzed. Results: One hundred patients underwent SLNB alone (n =67; patients with negative SLNB), complete LND (CLND) after positive SLNB (n=19), or radical LND without SLNB (n=14). Five-year overall survival and disease-free survival rates among these groups were 87.3%, 57.4%, and 61.9%, and 59.0%, 22.7%, and 28.1%, respectively. The complication rate in the SLNB alone group was lower than the other groups (22.4% vs. 47.4% and 35.7%, respectively; P=0.048). Seroma was the most common complication in the SLNB alone group (15.0%); lymphedema was most common in the CLND after SLNB group (21.1%). Multivariate analysis of risk factors for postoperative complications found the hazard ratio for body mass index >28 kg/m 2 was 4.376 (95% confidence interval [CI], 1.243-15.401; P=0.022). The hazard ratio for LND (including CLND after SLNB and radical LND without SLNB) was 3.263 (95% CI, 1.248-8.529; P=0.016). Conclusion: Inguinal LND is a higher risk procedure compared to SLNB and other sites for postoperative complications, irrespective of meticulous surgical techniques. More studies are needed to establish treatment protocols (e.g., observation vs. CLND after a positive SLNB result) and the risks and benefits in Asian populations.

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Radioguided Surgery for Breast Cancer

et al. 2022

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Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients

Cited by 7 publications

References 18 publications

Simple Prediction Model of Axillary Lymph Node Positivity After Analyzing Molecular and Clinical Factors in Early Breast Cancer

Simple Prediction Model of Axillary Lymph Node Positivity After Analyzing Molecular and Clinical Factors in Early Breast Cancer

Complications and outcomes following inguinal lymphadenectomy for malignant melanoma in an Asian population

Radioguided Surgery for Breast Cancer

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