Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection

Habib, Abdulrahman; Ali, Mohamed A.; Zouaoui, Baha R.; Taha, Mustafa Ahmed H.; Mohammed, Bassem Sahsah; Saquib, Nazmus

doi:10.1186/s12879-019-4555-5

Cited by 41 publications

(37 citation statements)

References 30 publications

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“…Our results showed high level of DPP4 expression levels in nasal turbinate and kidney. This may explains the multi-organs failure in some MERS-CoV patients particularly lung and kidneys [11]. Our results is very much consistent with the pathogenesis of MERS-CoV infection in human as well as the experimental infection of MERS-CoV in dromedary camels and other members of family Camelade [12].…”

supporting

confidence: 88%

The dipeptidyl peptidase-4 expression in some MERS-CoV naturally infected dromedary camels in Saudi Arabia 2018–2019

Alnaeem

Kasem

Qasim³

et al. 2020

VirusDis.

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supporting

confidence: 88%

The dipeptidyl peptidase-4 expression in some MERS-CoV naturally infected dromedary camels in Saudi Arabia 2018–2019

Alnaeem

Kasem

Qasim³

et al. 2020

VirusDis.

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“…However, no death was found in Jiangsu Province, which was bene t from good medical resourcesand earlier seek healthcare. Of course, these fractions of severe and critical infection would be higher than what was observed for in uenza virus infection [14] , but would be lower than severe acute respiratory syndrome(SARS) and middle east respiratory syndrome coronavirus (MERS-CoV) [15,16].…”

Section: Discussionmentioning

confidence: 88%

Early warning signs for severe patients with Coronavirus Disease 2019 and its epidemical significance

Dai

Jin³

et al. 2020

Preprint

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Background Since December 2019 coronavirus disease 2019 (COVID-19) emerged in Wuhan city and rapidly spread throughout China. However, early warning signs for severe patients with COVID-19 were not fully known.Methods Information on admission was collected through a standard questionnaire. We described the epidemiological characteristics of the patients with COVID-19, analyzed the risk factors associated with severe illness, and estimated the key epidemiologic time-delay distributions.Results A total of 631 patients with laboratory-confirmed COVID-19 were identified. The proportion of severe cases was 8.4%. The epidemic of COVID-19 experienced four stages: sporadic phase, exponential growth phase, peak plateau phase, and declining phase. The proportion of severe cases was significantly different in four stages and 13 municipal prefectures (P < 0.001). Factors including elderly more than 65years(yrs) old, underlying medical conditions, fever patient whose highest temperature beyond 39.0℃, dyspnea, and lymphocytopenia(< 1.0 × 109/L) could possibly become the early warning signs for severe patients of COVID-19. In contrast, earlier visit to the clinic could reduce the severe risk. Besides, the viral load may be a potentially useful marker associated with disease severity of COVID-19 infection.Conclusions The epidemic experienced four stages with obviously areas difference. People aged beyond 65 yrs or underlying medical conditions once appear symptoms like fever beyond 39.0℃ and/or dyspnea should immediately visit health care.

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“…There was a serious outbreak of SARS-CoV in China between 2002 and 2003 [12,13]. MERS-CoV also led to a serious epidemic in the Middle East in 2012, and caused mass mortality [14]. Cross-species infection and occasional spillover events may lead to the recurrent emergence of new coronaviruses [15].…”

Section: Discussionmentioning

confidence: 99%

Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

Gao

Zhou

et al. 2020

Preprint

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Background: In December 2019, Wuhan witnessed the outbreak of an “unexplained pneumonia” caused by a novel coronavirus strain infection and was dubbed the COVID-19 by the WHO. The disease quickly spread to China. This study aimed to investigate the disease’s evolving epidemiological history, as well as analyze the clinical and CT imaging characteristics, treatment regimens, and patients’ prognosis.Methods: This was a retrospective study whose cases were 64 patients with a confirmed diagnosis of COVID-19. The clinical data were obtained from patients who were admitted to the isolation ward from 21 January 2020 to 19 February 2020.Results: 60 out of 64 patients had a definitive history of exposure to people who had traveled from Wuhan City. The median time from onset of symptoms to first hospital admission was 3.9±1.9 days. The initial symptoms included fever (46/64), dry cough (38/64), fatigue or myalgia (23/64), sore throat (10/64), diarrhea (3/64) along with late-onset symptoms like chest pains (2/64) and headaches (2/64). The majority of the patients (43/64) had normal white blood cell counts while 29.7 % (19/64) had leukopenia. Only two patients (3.1 %) presented with leukocytosis. 58 of the 64patients had abnormal radiological findings on chest CTs. The first chest CTs (within 2 days) was more sensitive in detecting COVID-19 infection (85.9 %) compared to the initial RT-PCR (56.3 %; p<0.01). The CTs showed lesions in multiple lung lobes in three-quarters of the patients while 15.6 % had lesions localized to one lobe. Most of the lesions were typically dense with ground-glass opacity co-existing with consolidation or cord-like shadows. Most of these patients (50/64) have recovered and got discharged giving a mean length of hospital stay of 13.5±4.8 days. Our hospital unit has not reported any COVID-19 related death so far. Conclusions: Early intervention in COVID-19 disease improves patients’ prognosis. Our data demonstrate the superiority of early radiological tests ahead of RT-PCR. The initial and dynamic CT changes in COVID-19 patients along with other clinical data shared above can better guide clinical decision making.

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Clinical outcomes among hospital patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection

Cited by 41 publications

References 30 publications

The dipeptidyl peptidase-4 expression in some MERS-CoV naturally infected dromedary camels in Saudi Arabia 2018–2019

The dipeptidyl peptidase-4 expression in some MERS-CoV naturally infected dromedary camels in Saudi Arabia 2018–2019

Early warning signs for severe patients with Coronavirus Disease 2019 and its epidemical significance

Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

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