Clinical outcomes among patients with chronic kidney disease hospitalized with diabetic foot disorders: A nationwide retrospective study

Abstract

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The association between estimated glomerular filtration rate and prognosis in patients with diabetic foot osteomyelitis

“…29 Hypertension caused by renal insufficiency may lead to endothelial dysfunction, worsening of the lower limb ischemia, which harms the process of wound healing. 29 Several studies 19,21,30,31 revealed that renal insufficiency (eGFR <60 mL/min/1.73 m 2 ) was a risk factor for amputation in DFU patients. Our study confirms that severe reduced eGFR is associated with amputation risk after adjusting the confounders, including the PAD and infection degree (OR = 4.50, P = .03).…”

“…A large number of studies have revealed that DFU patients may have adverse outcomes when combined with renal insufficiency, especially in patients with severe renal dysfunction or dialysis. 19 , 20 , 21 A retrospective study 22 about the long‐term diabetic complications as predictors of foot ulcers healing failure revealed that eGFR <60 mL/min/1.73 m 2 was an independent risk factor for poor wound healing. However, among patients with DFUs, patients with DFO are more complicated and worse prognosis than those without osteomyelitis.…”

“…Several studies 19 , 21 , 30 , 31 revealed that renal insufficiency (eGFR <60 mL/min/1.73 m 2 ) was a risk factor for amputation in DFU patients. Our study confirms that severe reduced eGFR is associated with amputation risk after adjusting the confounders, including the PAD and infection degree (OR = 4.50, P = .03).…”

Relationship Between Chronic Kidney Disease and Diabetic Foot Ulcers

“…Additionally, severe amputations occurred in 31.98% of cases in the first year and 34.01% between the second and fifth years [5]. Patients entering the dialysis stage, whether hemodialysis or peritoneal dialysis, face a risk of DFU that is more than four times higher [6], and the incidence of amputation and sepsis will be more frequent, and the hospital stay will be longer [7]. The survival rate of DFU maintained dialysis patients was significantly lower than that of patients without foot ulcers [8].…”