Clinical Outcomes and Cardiovascular Responses to Different Exercise Training Intensities in Patients With Heart Failure

Ismail, Hashimah; McFarlane, James R.; Nojoumian, Amir Hadi; Dieberg, Gudrun; Smart, Neil A.

doi:10.1016/j.jchf.2013.08.006

Cited by 163 publications

(120 citation statements)

References 16 publications

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“…This beneficial trend in anxiety development together with no negative trends in other secondary end points, support the statements of HIT as a safe exercise modality in HF patients (99), and in maintenance HTx patients (18,24,30). The long-term difference in anxiety between the HIT group and the control group is considered a valuable finding, as anxiety is a frequent health issue after HTx, especially in the long-term follow-up (67).…”

Section: Hit Intervention and The Long-term Effectssupporting

confidence: 72%

Peak oxygen uptake and self‐reported physical health are strong predictors of long‐term survival after heart transplantation

Yardley

Havik

Grov

et al. 2015

Clinical Transplantation

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Background Peak oxygen uptake (VO2peak) is known as the gold standard measure of cardiopulmonary fitness. We therefore hypothesized that measures of physical health would predict long‐term survival in heart transplant recipients (HTx). Methods This retrospective study investigated survival in two HTx populations; the cardiopulmonary exercise test (CPET) cohort comprised 178 HTx patients who completed a VO2peak test during their annual follow‐up (1990–2003), and the SF‐36 cohort comprised 133 patients who completed a quality of life questionnaire, SF‐36v1 (1998–2000). Results Mean (SD) age in the CPET cohort was 52 (12) yr and 54 (11) yr in the SF‐36 cohort. Mean observation time was, respectively, 11 and 10 yr. Mean (SD) VO2peak was 19.6 (5.3) mL/kg/min, and median (IR) physical function (PF) score was 90 (30). VO2peak and PF scores were both significant predictors in univariate Cox regression. Multiple Cox regression analyses adjusted for other potential predictors showed that VO2peak, age, and cardiac allograft vasculopathy (CAV) were the most important predictors in the CPET cohort, whereas age, PF score, smoking, and CAV were the most important predictors in the SF‐36 cohort. In Kaplan–Meier analysis, VO2peak and PF scores above the median value were related to significant longer survival time. Conclusion Peak oxygen uptake and self‐reported physical health are strong predictors for long‐term survival in HTx recipients. VO2peak is a crucial measurement and should be more frequently used after HTx.

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Section: Hit Intervention and The Long-term Effectssupporting

confidence: 72%

Peak oxygen uptake and self‐reported physical health are strong predictors of long‐term survival after heart transplantation

Yardley

Havik

Grov

et al. 2015

Clinical Transplantation

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“…Dostępne są dowody wskazujące, że u pacjentów z HFpEF trening fizyczny przynosi wiele korzyści, w tym wpły-wa na poprawę wydolności wysiłkowej, określaną obiektywnie za pomocą oceny pochłaniania tlenu na szczycie wysiłku, poprawę jakości życia i funkcję rozkurczową ocenianą w badaniu echokardiograficznym [321,620,621,634].…”

Section: Trening Wysiłkowyunclassified

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Ponikowski

Voors

Anker³

et al. 2016

Kardiol Pol

460

446

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“…Individualized treatments, including secondary prevention, reduce hospital admissions rates, improve quality of life, and decrease CHD mortality by 42% [2,3]. The complications and concomitant diseases of CHD reflect the urgent need for cardiac rehabilitation (CR) to improve patients' quality of life [4].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Screened microRNAs related to endothelial progenitor cells and verified the target gene of microRNA-126-3p

Deng¹,

Xu²,

Li³

et al. 2018

Oncotarget

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Background: Endothelial progenitor cell play a vital role in neovascularization. Exercise-based cardiac rehabilitation significantly increases endothelial progenitor cells number and functions in patients with ischemic disease. Exercise can also increase the level of endothelial microRNAs. We hypothesized that microRNAs participate in regulating endothelial progenitor cell function under aerobic exercise. Thus, we attempted to identify such microRNAs and to verify the miR-126-3p target gene.Methods: Microarray is used to screen the microRNAs. The prediction programs TargetScan is used to predict the miR-126-3p target gene. Experimental EPCs are treated with miR-126-3p mimics. The relative expression of miR-126-3p and Mus musculus sprouty-related EVH1 domain-containing 1 (Spred1) are examined using real-time PCR and western blot. The dual-luciferase reporter assay is used to verify the miR-126-3p target gene.Results: The miR-126-3p target genes included those contributing to angiogenesis and revascularization. The predicted miR-126-3p target gene is Spred1. Compared with the control, miR-126-3p relative expression is highest following 48-h treatment with 50 nM miR-126-3 mimic. Spred1 mRNA and protein expression in the experimental group is 40.7% and 45.7%. The ratio of Renilla and firefly luciferase activity in the wild-type group is 88.3% and 74.2% of the control respectively (all, n = 3, p < 0.001).Conclusion: miR-126-3p participates in regulating endothelial progenitor cell function after aerobic exercise. MiR-126-3p inhibits the transcription and translation of Spred1, the target gene of miR-126-3p.

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Clinical Outcomes and Cardiovascular Responses to Different Exercise Training Intensities in Patients With Heart Failure

Abstract: As exercise training intensity rises, so may the magnitude of improvement in cardiorespiratory fitness, accompanied by lower study withdrawal in exercising patients. Total exercise time may be a confounder.

Cited by 163 publications

References 16 publications

Peak oxygen uptake and self‐reported physical health are strong predictors of long‐term survival after heart transplantation

Peak oxygen uptake and self‐reported physical health are strong predictors of long‐term survival after heart transplantation

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

WITHDRAWN: Screened microRNAs related to endothelial progenitor cells and verified the target gene of microRNA-126-3p

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