Clinical outcomes and complications of treatment with supraflex stent in patients with coronary artery disease: One-year follow-up

Sharifi, Zahra Nadia; Yazdi, Majid Jalal; Eshraghi, Ali; Vakili, Vida; Ramezani, Javad

doi:10.4081/ejtm.2019.8231

Cited by 6 publications

(5 citation statements)

References 30 publications

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“…Despite the continuously improved and new advances in the design of new-generation DES with thinner struts and biodegradable-polymer, this technology still presents several limitations such as inadequate expansion, expansive remodelling, abnormal vasomotion and the occurrence of neoatherosclerosis, in-stent restenosis (ISR), and stent thrombosis. 10 , 11 In simple lesion characteristic models this new-generation DES has shown to have a permanent risk of target lesion failure (TLF) ranging between 0.8% and 1% yearly. 12 Despite such devices were not assessed in more complex lesion settings (chronic total occlusions, complex bifurcations, very long lesions, highly calcific lesions), we can argue that the outcome would be even worse in such cases.…”

Section: Stent Overviewmentioning

confidence: 99%

Back to the future: DCB use instead of DES for the treatment of complex, native coronary artery disease

Cortese

Sanchez-Jimenez

2021

European Heart Journal Supplements

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The increasing complexity of coronary artery lesions in patients with significant co-morbidities and the need for revascularization, but with the ineligibility for surgical approach, has turned the percutaneous coronary intervention a challenging task, especially in a setting in which short- and long-term complications after drug-eluting stent implantation are high. Drug-coated balloons (DCBs) have become an important tool to replace stent placement in specific situations such as small coronary artery disease and in-stent restenosis. Although preliminary data of DCB use in complex lesions is promising, the available data are still limited. Therefore, in this article, we review the most recent and relevant literature about the use of DCB in native vessel disease and in complex anatomies/patients, and pretend to justify the necessity to develop well design trials about the use of this therapy in such settings, also thinking at DCBs as a complementary tool to drug-eluting stents.

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Section: Stent Overviewmentioning

confidence: 99%

Back to the future: DCB use instead of DES for the treatment of complex, native coronary artery disease

Cortese

Sanchez-Jimenez

2021

European Heart Journal Supplements

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“…Myocardial infarction often occurs as a result of sudden coronary artery failure, causing necrosis and inappropriate cardiac muscle function. 13 Treatment is often a percutaneous coronary intervention, 14 but an early and precise ECG diagnosis is mandatory. RVMI indicates damage to the right ventricular muscle.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of standard electrocardiogram in acute right ventricular myocardial infarction

et al. 2019

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Myocardial infarction (MI) (i.e., heart attack) is the irreversible death (necrosis) of heart muscle secondary to prolonged lack of oxygen supply (ischemia) which accounts for a large number of deaths in the hospital. Diagnosis of myocardial infarction is confirmed based on clinical manifestations and electrocardiographic changes along with increased cardiac enzymes. Electrocardiogram (ECG) is one of the safest and easiest methods in the first place. Therefore, this study aimed to investigate the diagnostic value of standard electrocardiogram in the diagnosis of acute right ventricular infarction following lower cardiac infarction. This research was carried out at a time interval of one and a half years to diagnose acute primary infarction. In this method, the diagnostic value of ST↓ in lead I, ST↓ in lead aVL and I ST↓ + aVL, compared with ST↑ in lead V4R was investigated for diagnosis of right ventricular infarction. ST↑ in the lead V4R is a gold standard for the detection of right ventricular MI. All the patients who had the inclusion criteria were allowed to participate in the study. A total of 66 patients participated in the study. Accordingly, 58 (87%) were male and 8 (13%) were female. The mean age of the population was 54.9 ± 11.41. According to the ST↑ standard in lead V4R, 26 patients (39%) had right ventricular myocardial infarction. There was no significant relationship between angina pectoris and premature infarction (P-Value = 0.869). In this study, the right ventricular was most commonly involved in right coronary artery (RCA) (78%). There was no significant relationship between the occlusion of right coronary artery and right ventricular infarction in 60 patients (P-Value = 0.94). The results showed that electrocardiogram manifestations help determine the occlusion site and the area at risk (ST↓ in lead aVL and aVL + I, sensitivity = 96%). In myocardial infarction, symptoms such as the ST-Segment elevation in lead aVR and ST-Segment depression in the lower leads are possible. Accordingly, in the lower infarction, ST changes in the leads V1-V6 are helpful in detecting patients at risk. Thus, the use of electrocardiogram in acute myocardial infarction (AMI) helps detect more invasive patients and prevents extensive myocardial damage and other complications.

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“…Cardiovascular disease is associated with the highest rates of morbidity and mortality worldwide [1].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of Fruitflow on platelet function: a randomized placebo-controlled trial in elderly subjects

Chen¹,

Zhang

Wang

et al. 2021

Preprint

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Background: The elderly has a high risk of cardiovascular disease, which is often accompanied by platelet hyperactivity. Tomato extracts can inhibit platelet activation and have beneficial health effects. We aimed to investigate the effect of Fruitflow® (FF), a water-soluble tomato extract, on platelet function in elderly participants.Methods: This randomized group study was conducted with people over 50 years old. The participants were randomly divided into four groups: placebo (150 mg/day), FF (150 mg/day), acetylsalicylic acid (ASA; 100 mg/day), and FF (150 mg/day) + ASA (100 mg/day). These groups received the respective supplements after dinner daily for 7 days. Fasting blood was collected from the participants on days 0 and 8 to analyze platelet aggregation and the content of thromboxane B2 (TXB2), 6-keto-prostaglandin F1α, and platelet factor 4 (PF4). Results: One hundred ninety elderly participants were recruited and completed this clinical trial. The results showed that the FF intervention for 7 days decreased platelet aggregation by 7.7% in adenosine diphosphate-stimulated platelets, which was similar to the effect of ASA, which decreased platelet aggregation by 9.4%. FF reduced platelet aggregation by 10.2% in collagen-stimulated platelets, and ASA reduced platelet aggregation by 38.3% in collagen-activated platelets. This suggests that ASA exerts a stronger inhibitory effect than FF on collagen-stimulated platelet aggregation. The combination of FF + ASA did not exert a synergistic inhibitory effect on platelet aggregation. Treatment with FF significantly decreased plasma TXB2, 6-keto-PGF1α, and PF4 levels, and its effects were similar to ASA. Conclusion: Fruitflow® suppressed platelet aggregation and decreased TXB2, 6-keto-PGF1α, and PF4 levels in elderly participants. These findings indicate that FF might reduce the risk of thrombosis in cardiovascular diseases.Trial registration code: ChiCTR2000034647 at www.clinicaltrials.gov.

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Clinical outcomes and complications of treatment with supraflex stent in patients with coronary artery disease: One-year follow-up

Cited by 6 publications

References 30 publications

Back to the future: DCB use instead of DES for the treatment of complex, native coronary artery disease

Back to the future: DCB use instead of DES for the treatment of complex, native coronary artery disease

Diagnostic value of standard electrocardiogram in acute right ventricular myocardial infarction

Inhibitory effect of Fruitflow on platelet function: a randomized placebo-controlled trial in elderly subjects

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