Clinical outcomes and costs associated with procalcitonin utilization in hospitalized patients with pneumonia, heart failure, viral respiratory infection, or chronic obstructive pulmonary disease

Johnson, Stacy A.; Rupp, Austin B.; Rupp, K; Reddy, Santosh

doi:10.1007/s11739-020-02618-3

Cited by 4 publications

(4 citation statements)

References 34 publications

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“…A similar trend was reflected in the IL-10 level of the G-group. Some studies have shown that PCT can be used as an indicator of infectious diseases, infection severity and disease prognosis (32)(33)(34). However, a single PCT has some limitations, and other indicators often need to be combined in clinical practice (35).…”

Section: Discussionmentioning

confidence: 99%

IL-6 and IL-10 Are Associated With Gram-Negative and Gram-Positive Bacteria Infection in Lymphoma

Zhu

Li²,

Zheng³

et al. 2022

Front. Immunol.

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To investigate the Th1/Th2 cytokine profile in patients with lymphoma during the myelosuppression stage of infection. 52 patients with gram-negative bacterial infection (G- group), 49 patients with gram-positive bacterial infection (G+ group), 51 uninfected patients with lymphoma (uninfected group) and 20 healthy controls (healthy group) were enrolled in this study. We evaluated the quantification of Th1/Th2 cytokines with flow cytometry bead assay (CBA) in the sera to explore a rapid diagnostic method to determine the type of infection and anti-infective effect. The levels of procalcitonin (PCT) were also detected simultaneously. The four groups did not differ with regard to IL-2 and IL-4 (P>0.05). The IFN-γ and TNF-α levels of patients with lymphoma were higher than those of healthy controls (P<0.05). There was significantly upregulated IL-6 and IL-10 expression in the G- group (P<0.001). A similar trend was reflected in the IL-6 of the G+ group, which was significantly increased (P<0.001). However, no significant upregulation was observed for IL-10 in the G+ group. According to the different degrees of increased IL-6 and IL-10 levels, We proposed to use the G- Bacterial Infection Cytokine Profile (G- BICP) and the G+ Bacterial Infection Cytokine Profile (G+ BICP) for the first time to differentiate between Gram-negative and Gram-positive (G-/G+) bacterial infection in adults with lymphoma in the myelosuppression stage after chemotherapy. The IL-6, IL-10 and PCT in the G- group and the IL-6, PCT in the G+ group were significantly decreased at day 4 and day 8 compared with those at day 1. IL-6 and IL-10 are closely associated with the severity and treatment efficacy in adults with lymphomas who develop infections after chemotherapy and can help distinguish between G- and G+ bacterial infections at an early stage.

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Section: Discussionmentioning

confidence: 99%

IL-6 and IL-10 Are Associated With Gram-Negative and Gram-Positive Bacteria Infection in Lymphoma

Zhu

Li²,

Zheng³

et al. 2022

Front. Immunol.

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“… 3 Among them, respiratory tract infections are also the most common trigger for heart failure or aggravation of heart failure symptoms. 4 …”

Section: Introductionmentioning

confidence: 99%

Study on the clinical efficacy, safety and compliance of quality nursing intervention in the treatment of chronic heart failure combined with respiratory tract infections

Jia,

Li,

Zhang

et al. 2024

Pak J Med Sci

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Objective: To evaluate the clinical efficacy, safety and compliance of quality nursing intervention in the treatment of chronic heart failure combined with respiratory tract infections. Methods: This was a retrospective study. One hundred and twenty patients with chronic heart failure combined with respiratory tract infections were recruited at Baoding No.1 Central Hospital from June 2021 to March 2023 and randomly divided into the control group (n=60) and the experimental group (n=60). Patients in the control group were given regular specialist care on the basis of basic treatment, while those in the experimental group were given a quality care intervention model. The differences in clinical efficacy, improvement time of symptoms after treatment, etc. between the two groups were compared and analyzed. Results: The response rate of the experimental group was 88%, which was significantly higher than that of the control group (73%), with a statistically significant difference (P=0.04). The time of fever reduction, cough subsidence and lung rales disappearance in the experimental group were significantly shorter than those of the control group, with statistically significant differences (P<0.05). The incidence of nursing related adverse events in the experimental group was 8%, which was lower than that of 23% in the control group, with a statistically significant difference(P=0.03). Conclusion: Quality nursing intervention is an effective treatment for patients with chronic heart failure combined with respiratory infections, boasting a variety of benefits such as reduced nursing risk, improved quality of nursing, and increased patient compliance and satisfaction. It contributes to rapid symptom improvement and significant clinical efficacy. doi: https://doi.org/10.12669/pjms.40.7.7873 How to cite this: Jia Y, Li N, Zhang X, Lu Z, You X, Xu Q. Study on the clinical efficacy, safety and compliance of quality nursing intervention in the treatment of chronic heart failure combined with respiratory tract infections. Pak J Med Sci. 2024;40(7):---------. doi: https://doi.org/10.12669/pjms.40.7.7873 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…In a recent real-world study on hospitalized patients admitted with respiratory symptoms and suspected lower respiratory tract infection (LRTI), Johnson et al evaluated clinical outcomes and costs associated with PCT use in different clinical situations: patients with pneumonia, heart failure, viral respiratory infection, and chronic obstructive pulmonary disease [4]. Of importance, the PCT assessment was associated with reduced antibiotic use, length of stay, and mortality.…”

mentioning

confidence: 99%

“…It is important to underline that monitoring PCT levels can allow early detection of bacterial infections, which may reduce inappropriate prescription of antibiotics or trigger an early antibiotic therapy to treat the first stage of sepsis and other severe infective conditions [15]. Of importance, all the observed advantages associated with PCT utilization in the study of Johnson et al were limited to patients not requiring intensive care unit (ICU) admission [4]. In this context, the use of PCT resulted to be more efficacious in ICU patients where the decrease of PCT of > 80% over 72 h from ICU admission may provide prognostic information in critically ill patients and drive physicians to the discontinuation of antibiotic therapy [16][17][18].…”

mentioning

confidence: 99%

Procalcitonin in daily clinical practice: an evergreen tool also during a pandemic

et al. 2021

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Clinical outcomes and costs associated with procalcitonin utilization in hospitalized patients with pneumonia, heart failure, viral respiratory infection, or chronic obstructive pulmonary disease

Cited by 4 publications

References 34 publications

IL-6 and IL-10 Are Associated With Gram-Negative and Gram-Positive Bacteria Infection in Lymphoma

IL-6 and IL-10 Are Associated With Gram-Negative and Gram-Positive Bacteria Infection in Lymphoma

Study on the clinical efficacy, safety and compliance of quality nursing intervention in the treatment of chronic heart failure combined with respiratory tract infections

Procalcitonin in daily clinical practice: an evergreen tool also during a pandemic

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