Clinical Outcomes and Prognosis of Patients With Interstitial Lung Disease Undergoing Lung Cancer Surgery: A Propensity Score Matching Study

Ki, Min Seo; Kim, Song Yee; Kim, Eun Young; Jung, Ji Ye; Kang, Young Ae; Park, Moo Suk; Kim, Young Sam; Park, Sung Yong; Lee, Sang Hoon

doi:10.1016/j.cllc.2022.10.003

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…Several studies have reported poor clinical outcomes in lung cancer patients with preoperative fibrosis 13 or interstitial lung disease. 14 Although it is still too early to classify lung plication as one of these pathogenic findings, plication can limit lung inflation and lead to detrimental effects when patients are exposed to other respiratory insults. Therefore, further assessment and interpretation of plications are necessary to evaluate the lasting effects after segmentectomies.…”

Section: Discussionmentioning

confidence: 99%

Segmentectomy quality remains important in ground‐glass‐dominant stage I lung cancer

Woo,

Lee,

Jin

et al. 2023

Thoracic Cancer

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BackgroundSegmentectomy for early‐stage lung cancer has benefits for survival and parenchymal preservation. However, segmentectomies are technically challenging, thereby resulting in considerable variability in the quality of resection. In this study, we aimed to review the quality of segmentectomies and analyze their clinical impact.MethodsThis retrospective study reviewed patients diagnosed with stage I lung cancer after segmentectomies between 2013 and 2021. Segmentectomies were classified as anatomical or nonanatomical; anatomical resection included segmental bronchus and vessel (artery and/or vein) divisions; others were classified as nonanatomical. The primary outcome was recurrence‐free and overall survival, and the secondary outcome was postoperative spirometry and lung plication, which is seen as a fibrotic line along the stapling site.ResultsOf the 132 segmental resections included in this study, 101 (76.5%) were anatomical segmentectomies. The median consolidation‐tumor ratio was 0.40, and 83.3% (110/132) had ground‐glass opacities (GGOs). Compared to nonanatomical resections, more N1 and total lymph node stations were retrieved after anatomical segmentectomies. Regarding clinical outcomes, recurrence‐free survival was better after anatomical segmentectomy (p = 0.049); however, overall survival was not significantly different (p = 0.064). Furthermore, at 3–6 months postoperatively, thicker lung plication at the stapling site was observed in nonanatomical resections (p < 0.001). Subgroup analysis for complex segmentectomies revealed a larger decrease in forced‐expiration volume in 1 s after nonanatomical resection.ConclusionAnatomical segmentectomy resulted in better survival and a lower incidence of thick lung plication, even in GGO‐dominant tumors. Therefore, further standardization and quality management of segmentectomy procedures will improve the clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Segmentectomy quality remains important in ground‐glass‐dominant stage I lung cancer

Woo,

Lee,

Jin

et al. 2023

Thoracic Cancer

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“…Min Seo Ki et al [87] demonstrated in a propensity score matching study of 104 patients that long term prognosis is affected negatively in ILD (5-year survival rate 66% vs 78.8%, P= .007), although there was no difference between groups in postoperative mortality [87]. Moreover, mortality was significantly higher in patients with a stage III ILD-GAP score [87].…”

Section: Surgical Therapymentioning

confidence: 99%

Lung Cancer and Interstitial Lung Diseases

Drakopanagiotakis,

Krauss,

Michailidou

et al. 2024

Preprint

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Lung cancer remains one of the leading causes of cancer-related mortality worldwide. There is evidence of a complex interplay between lung cancer and interstitial lung disease (ILD), affecting disease progression, management strategies, and patient outcomes. Both conditions develop as the result of common risk factors such as smoking, environmental exposures, and genetic predispositions. The presence of ILD poses diagnostic and therapeutic challenges in lung cancer management, including difficulties in interpreting radiological findings, increased susceptibility to treatment-related toxicities, such as acute exacerbation of ILD after surgery and pneumonitis after radiation therapy and immunotherapy. Moreover, due to the lack of large, phase III randomized controlled trials in patients with lung cancer and ILDs, the evidence-based therapeutic options remain limited. The role of antifibrotic treatment in the prevention of lung-cancer-related treatment toxicities remains to be elucidated. Emerging diagnostic modalities and biomarkers, and optimizing personalized treatment strategies are essential to improve outcomes in this patient population.

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Impact of interstitial lung disease gender-age-physiology index in surgically treated lung cancer

Sakamoto,

Kawakita,

Takeuchi

et al. 2024

Int J Clin Oncol

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Clinical Outcomes and Prognosis of Patients With Interstitial Lung Disease Undergoing Lung Cancer Surgery: A Propensity Score Matching Study

Cited by 4 publications

References 39 publications

Segmentectomy quality remains important in ground‐glass‐dominant stage I lung cancer

Segmentectomy quality remains important in ground‐glass‐dominant stage I lung cancer

Lung Cancer and Interstitial Lung Diseases

Impact of interstitial lung disease gender-age-physiology index in surgically treated lung cancer

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