Clinical outcomes and risk factors for death from disseminated histoplasmosis in patients with AIDS who visited a high-complexity hospital in Campo Grande, MS, Brazil

Boigues, Barbara Cristina Scarcelli; Paniago, Anamaria Mello Miranda; Lima, Gláucia Moreira Espíndola; Nunes, Maína de Oliveira; Uehara, Silvia Naomi de Oliveira

doi:10.1590/0037-8682-0369-2017

Cited by 18 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prescribed antifungal therapy was effective, and ART has allowed an immune viral control, which is essential for reducing the risk of H. capsulatum reactivation [28]. …”

Section: Discussionmentioning

confidence: 99%

An Italian Case of Disseminated Histoplasmosis Associated with HIV

Papalini

Belfiori

Martino

et al. 2019

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

Histoplasma capsulatum is a dimorphic fungus, endemic in the Americas, Africa (var. duboisii), India, and Southeast Asia. H. capsulatum infection is rarely diagnosed in Italy, while in Latin America, progressive disseminated histoplasmosis (PDH) is one of the most frequent AIDS-defining illnesses and causes of AIDS-related deaths. We report a case of PDH and new HIV infection diagnosis in a Cuban patient, who has been living in Italy for the past 10 years. Bone marrow aspirate and peripheral blood smear microscopy suggested H. capsulatum infection. The diagnosis was confirmed with the culture method identifying its thermal dimorphism. Liposomal amphotericin B was administered alone for 10 days and then for another 2 days, accompanied with voriconazole; the former was stopped for probable side effects (persistent fever and worsening thrombocytopenia), and voriconazole was continued to complete 4 weeks. PDH maintenance treatment consisted of itraconazole for one year. Antiretroviral therapy (ART) was started on the third week of antifungal treatment. At the 3-year follow-up, the patient is adherent on ART, the virus was suppressed, and she has an optimal immune recovery. This case highlights the need to suspect histoplasmosis in the differential diagnosis of opportunistic infections in immunocompromised persons, native to or who have traveled to endemic countries.

show abstract

“…The prescribed antifungal therapy was effective, and ART has allowed an immune viral control, which is essential for reducing the risk of H. capsulatum reactivation [28]. …”

Section: Discussionmentioning

confidence: 99%

An Italian Case of Disseminated Histoplasmosis Associated with HIV

Papalini

Belfiori

Martino

et al. 2019

Case Reports in Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Raquel Silveira Bello Stucchi [1] , Athanase Billis [2] and Fabiano Reis [3] [1]. Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Clínica Médica, Campinas, SP, Brasil.…”

Section: Intracranial Hemorrhage Secondary To Disseminated Histoplasmunclassified

“…Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Clínica Médica, Campinas, SP, Brasil. [2]. Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Anatomia Patológica, Campinas, SP, Brasil.…”

Section: Intracranial Hemorrhage Secondary To Disseminated Histoplasmunclassified

Intracranial hemorrhage secondary to disseminated histoplasmosis in AIDS: an uncommon presentation

Stucchi

Billis

Reis

2021

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

“…(2) In most of these studies, TB diagnosis was done by direct microscopic observation of acid-fast-bacilli (AFB) in specimens from symptomatic people, without microbiological confirmation by culture. (3) Treatment failures were frequently reported [17,18,19,20,21,22,23,24,25,26]. Based on these reports, it is important to highlight the key role of laboratory testing in the diagnosis of histoplasmosis or TB, or the co-occurrence of these two conditions.…”

Section: Epidemiology Of Histoplasmosis/tb Co-occurrence In Peoplementioning

confidence: 99%

Histoplasmosis and Tuberculosis Co-Occurrence in People with Advanced HIV

Cáceres

Valdés

2019

JoF

View full text Add to dashboard Cite

Distinguishing between histoplasmosis, tuberculosis (TB), and co-occurrence of disease is a frequent dilemma for clinical staff treating people with advanced Human Immunodeficiency Virus (HIV) infection. This problem is most frequently observed in clinical settings in countries where both diseases are endemic. It is also a challenge outside these endemic countries in HIV clinics that take care of patients coming from countries with endemic histoplasmosis and TB. The gold standard for diagnosis of both of these diseases is based on conventional laboratory tests (culture, histopathology and special stains). These tests have several limitations, such as lack of laboratory infrastructure for handling isolates (biosafety level 3), shortage of laboratory staff who have appropriate training and experience, variable analytical performance of tests and long turn-around time. Recently, novel rapid assays for the diagnosis of histoplasmosis and TB became available. However, this technology is not yet widely used. Mortality in immunocompromised patients, such as people with advanced HIV, is directly linked with the ability to rapidly diagnose opportunistic diseases. The aim of this review is to synthesize the main aspects of epidemiology, clinical characteristics, diagnosis and treatment of histoplasmosis/TB co-occurrence in people with advanced HIV.

show abstract

Clinical outcomes and risk factors for death from disseminated histoplasmosis in patients with AIDS who visited a high-complexity hospital in Campo Grande, MS, Brazil

Abstract: The mortality rate for DH is high among severely immunocompromised patients with AIDS. The risk factors for death were those traditionally associated with blood dyscrasia, inflammatory activity, as well as increased renal and nutritional impairment.

Cited by 18 publications

References 10 publications

An Italian Case of Disseminated Histoplasmosis Associated with HIV

An Italian Case of Disseminated Histoplasmosis Associated with HIV

Intracranial hemorrhage secondary to disseminated histoplasmosis in AIDS: an uncommon presentation

Histoplasmosis and Tuberculosis Co-Occurrence in People with Advanced HIV

Contact Info

Product

Resources

About