Clinical outcomes in allogeneic haematopoietic stem cell transplantation: A comparison between young and elderly patients. Observational study

Abstract

Objectives To analyse clinical outcomes comparing two age groups of patients undergoing allogeneic haematopoietic stem cell transplantation (allo‐HSCT), and to identify risk factors associated with older patients’ mortality. Methods In this retrospective study, the medical charts of all consecutive patients admitted in one hospital for allo‐HSCT were reviewed. Overall survival (OS) and other outcomes were compared between patients aged up to 55 years (YG) and older than 55 (EG). Results From January 2007 to August 2014, 111 adult patients were admitted for allo‐HSCT and were included 75 in the YG and 36 in the EG group. The OS rate at D+ 100 was 84% for YG individuals in contrast to 75% in the EG (p = 0.01), and 71% vs. 50% at one year after HSCT (p = 0.01) respectively. Therapy‐related mortality (TRM) rates for the YG and EG were, respectively, 14% vs. 17% (p = 0.04) at D+ 100 and 17% vs. 32% (p = 0.04) at one year. Haploidentical donor type and active disease status significantly increased mortality risk in the EG (hazard ratio 2.42; p = 0.018; and 2.04; p = 0.033). Conclusion YG and EG have similar TRM rates early after allo‐HSCT, but the elderly had higher TRM during the critical period from 100 days to one year.

Need for hemodialysis in patients undergoing hematopoietic stem cell transplantation: risk factors and survival in a retrospective cohort

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“…Based on a previous study, 9 we separated patients using the 55-year-old threshold, as the older group might experience higher toxicities rates, that indeed may occur later due to lower intensity conditioning regimens. Other age thresholds were also tested according to the non-parametric receiver operating characteristic (ROC) curve statistical analysis between age and hemodialysis.…”