Clinical Outcomes of 3D-Printed Bioresorbable Scaffolds for Bone Tissue Engineering—A Pilot Study on 126 Patients for Burrhole Covers in Subdural Hematoma

Toh, Emma Min Shuen; Thenpandiyan, Ashiley Annushri; Foo, Aaron Song Chuan; Zhang, John J.Y.; Lim, Mervyn Jun Rui; Goh, Chun Peng; Dinesh, Nivedh; Vedicherla, Srujana V.; Yang, Ming; Teo, Kejia; Yeo, Tseng Tsai; Nga, Vincent Diong Weng

doi:10.3390/biomedicines10112702

Cited by 11 publications

(8 citation statements)

References 55 publications

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“…At present, it is much accounted of biological materials in tissue repairing and many of them are FDA-approved for clinical conversion like 3D-print polycaprolactone scaffold [ 43 ], such as Osteoplug TM proven to be safe over a 10-year period for craniotomy burr hole reconstruction [ 44 ] and reducing scalp-depression-related cosmetic handicaps in patients [ 45 ]. However, in orthopedics, bone repair cannot be achieved with biological scaffolds alone, which often need to be combined with other related drugs or biological components to achieve therapeutic effects, like β-TCP [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner

Wang

Zhang

et al. 2023

Research

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Platelet-derived growth factor-BB (PDGF-BB)/platelet-derived growth factor receptor-β (PDGFR-β) pathway is conventionally considered as an important pathway to promote osteogenesis; however, recent study suggested its role during osteogenesis to be controversial. Regarding the differential functions of this pathway during 3 stages of bone healing, we hypothesized that temporal inhibition of PDGF-BB/PDGFR-β pathway could shift the proliferation/differentiation balance of skeletal stem and progenitor cells, toward osteogenic lineage, which leads to improved bone regeneration. We first validated that inhibition of PDGFR-β at late stage of osteogenic induction effectively enhanced differentiation toward osteoblasts. This effect was also replicated in vivo by showing accelerated bone formation when block PDGFR-β pathway at late stage of critical bone defect healing mediated using biomaterials. Further, we found that such PDGFR-β inhibitor-initiated bone healing was also effective in the absence of scaffold implantation when administrated intraperitoneally. Mechanistically, timely inhibition of PDGFR-β blocked extracellular regulated protein kinase 1/2 pathway, which shift proliferation/differentiation balance of skeletal stem and progenitor cell to osteogenic lineage by upregulating osteogenesis-related products of Smad to induce osteogenesis. This study offered updated understanding of the use of PDGFR-β pathway and provides new insight routes of action and novel therapeutic methods in the field of bone repair.

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Section: Resultsmentioning

confidence: 99%

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner

Wang

Zhang

et al. 2023

Research

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“…Similarly, another study reported 12 cases of uneventful burr hole reconstruction, observing simultaneous progressive bone regeneration [102]. Recent publications have noted that the use of PCL plugs resulted in effective bone regeneration after ~1 year (see Figure 4D) and significantly higher scores for both aesthetic outcomes and quality of life (QOL) without an increase in complication rates in comparison to patients with untreated burr holes who suffered from scalp depression [103,104].…”

Section: Three-dimensional-printed Pcl and Its Compositesmentioning

confidence: 95%

Biomaterials for Regenerative Cranioplasty: Current State of Clinical Application and Future Challenges

2024

JFB

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Acquired cranial defects are a prevalent condition in neurosurgery and call for cranioplasty, where the missing or defective cranium is replaced by an implant. Nevertheless, the biomaterials in current clinical applications are hardly exempt from long-term safety and comfort concerns. An appealing solution is regenerative cranioplasty, where biomaterials with/without cells and bioactive molecules are applied to induce the regeneration of the cranium and ultimately repair the cranial defects. This review examines the current state of research, development, and translational application of regenerative cranioplasty biomaterials and discusses the efforts required in future research. The first section briefly introduced the regenerative capacity of the cranium, including the spontaneous bone regeneration bioactivities and the presence of pluripotent skeletal stem cells in the cranial suture. Then, three major types of biomaterials for regenerative cranioplasty, namely the calcium phosphate/titanium (CaP/Ti) composites, mineralised collagen, and 3D-printed polycaprolactone (PCL) composites, are reviewed for their composition, material properties, and findings from clinical trials. The third part discusses perspectives on future research and development of regenerative cranioplasty biomaterials, with a considerable portion based on issues identified in clinical trials. This review aims to facilitate the development of biomaterials that ultimately contribute to a safer and more effective healing of cranial defects.

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“…From an engineering point of view, one of the main challenges in developing TE scaffolds is optimizing the scaffold design to meet biological requirements. It includes considering the ability to support cell seeding, cell differentiation, cell proliferation, and vascularization [6][7][8][9][10]. Therefore, an essential parameter in designing a scaffold must take into account the histomorphometric characteristics of the scaffold so that the requirements mentioned above can be met.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Tortuosity on Permeability of Porous Scaffold

et al. 2023

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In designing porous scaffolds, permeability is essential to consider as a function of cell migration and bone tissue regeneration. Good permeability has been achieved by mimicking the complexity of natural cancellous bone. In this study, a porous scaffold was developed according to the morphological indices of cancellous bone (porosity, specific surface area, thickness, and tortuosity). The computational fluid dynamics method analyzes the fluid flow through the scaffold. The permeability values of natural cancellous bone and three types of scaffolds (cubic, octahedron pillar, and Schoen’s gyroid) were compared. The results showed that the permeability of the Negative Schwarz Primitive (NSP) scaffold model was similar to that of natural cancellous bone, which was in the range of 2.0 × 10−11 m2 to 4.0 × 10−10 m2. In addition, it was observed that the tortuosity parameter significantly affected the scaffold’s permeability and shear stress values. The tortuosity value of the NSP scaffold was in the range of 1.5–2.8. Therefore, tortuosity can be manipulated by changing the curvature of the surface scaffold radius to obtain a superior bone tissue engineering construction supporting cell migration and tissue regeneration. This parameter should be considered when making new scaffolds, such as our NSP. Such efforts will produce a scaffold architecturally and functionally close to the natural cancellous bone, as demonstrated in this study.

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Clinical Outcomes of 3D-Printed Bioresorbable Scaffolds for Bone Tissue Engineering—A Pilot Study on 126 Patients for Burrhole Covers in Subdural Hematoma

Cited by 11 publications

References 55 publications

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner

Biomaterials for Regenerative Cranioplasty: Current State of Clinical Application and Future Challenges

The Effect of Tortuosity on Permeability of Porous Scaffold

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