Clinical Outcomes of Colorectal Cancer in Kenya

Saidi, Hassan; Abdihakin, M; Njihia, Benjamin; Jumba, G.E.; Kiarie, G; Githaiga, J; Abinya, NO

doi:10.4314/aas.v7i1.67029

Cited by 9 publications

(9 citation statements)

References 1 publication

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“…The mortality rates of CRC in East Africa have ranged from 10.5% to 29.4% which is higher than that reported in West Africa (6.1%) [16,46,57]. This high mortality may be due to the fact that many CRC patients in East Africa present at a late stage.…”

Section: Outcome Of Management Of Colorectal Adenocarcinomamentioning

confidence: 83%

“…In East Africa many patients present at an advance stage and so a number of surgical interventions have been reported. The majority of surgical operations for rectal carcinoma are abdominoperineal resections which are performed in up to between 54%-71% of patients [46][47][48][49] due to the advanced stage of presentation of rectal tumors. Anterior resections for rectal tumors have been reported in only up to between 22% -26% of patients [46,49] possibly because of the lack of facilities to provide chemotherapy and radiotherapy pre-operatively in rectal carcinoma in East Africa due to the advanced stage of presentation of rectal carcinoma.…”

Section: Treatment Of Colorectal Adenocarcinoma Patientsmentioning

confidence: 99%

“…The frequency of other operations documented in East African studies include right hemicolectomy in 22.1-43% of patients [16,46], left hemicolectomy in 33% -58.6% of patients [10,40], transverse colectomy in 3% -12% of patients and sigmoid colectomy in 3% of patients [16,46]. Table 3 shows the frequency of operations documented in East African studies.…”

Section: Treatment Of Colorectal Adenocarcinoma Patientsmentioning

confidence: 99%

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Colorectal Adenocarcinoma in East Africa: A Narrative Literature Review

Wismayer

2020

JAMMR

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This paper is a review of work done on colorectal adenocarcinoma in East Africa showing geographic spread, age and sex ratios, clinical presentation, management and predominant histopathology. A steady increased incidence of CRC in East African countries is currently being documented however this is associated with a higher CRC-associated morbidity and mortality. Whilst the male: Female ratio varies between 1.2:1 to 1.88:1, up to 38% of CRC diagnosis are in patients younger than 40 years, in contrast to only 1.9% of CRC patients in Western developed countries such as the USA. Generally rectal carcinoma is more common than colon carcinoma and abdomino-perineal resections are commonly performed in up to between 54% - 71% due to the advanced stage of presentation of rectal tumours in East Africa. The late stage presentation and delayed effective treatment in East Africa may result in a higher morbidity in CRC patients. Interestingly there is a significant incidence of mucinous adenocarcinoma sub-groups compared to Western developed countries which carry a poor prognosis. A significant proportion of CRC patients have been found to have histological and demographic features which suggest that MSI-tumours and these tumours are more common in younger patients. However only a few authors have looked at the possibility of mismatch repair mutations in the genetic aetiopathogenesis of colorectal adenocarcinoma in East Africa.

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Section: Outcome Of Management Of Colorectal Adenocarcinomamentioning

confidence: 83%

Section: Treatment Of Colorectal Adenocarcinoma Patientsmentioning

confidence: 99%

Section: Treatment Of Colorectal Adenocarcinoma Patientsmentioning

confidence: 99%

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Colorectal Adenocarcinoma in East Africa: A Narrative Literature Review

Wismayer

2020

JAMMR

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“…However many of these differences in survival are not entirely understood. 17 In East Africa and particularly in Uganda, the relationship of treatment in CRC patients to survival outcome remains unknown. A good indicator to detect the effectiveness of CRC treatment and early diagnosis in a population is through the analyses of cancer survival.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Factors for Survival of Colorectal Adenocarcinoma Patients in Uganda

Wismayer¹,

Kiwanuka²,

Wabinga³

et al. 2022

CMAR

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Background:In Uganda, similar to other countries in East Africa, the incidence of colorectal cancer (CRC) has been steadily increasing. This increase in incidence is accompanied by a poor prognosis. There is limited knowledge on factors responsible for the poor outcome of patients with CRC in Uganda. Cancer survival analysis is one way of determining some of these prognostic factors. The aim of this study was to determine prognostic factors associated with CRC survival in Ugandan patients. Methods: This was a retroprospective cohort study involving patients with linked data in the Kampala cancer registry and medical records from hospitals in Uganda. Participants with a diagnosis of colorectal adenocarcinoma between 1st January 2008 and 31st December 2018 were included. Variables included patients' demographic data, grade, stage and location of CRC, data on whether a patient was operated on, type of operation, treatment modalities and date of diagnosis. Our outcome variable was time to death after diagnosis. We computed and compared survival using the Log rank test and used Cox proportional hazards regression to determine factors associated with survival. Results: A total of 247 patients were included in the study with a mean (SD) age of 53.3 (15.7) years and a female:

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“…1,5 In an earlier study in Kenya, CRC mortality was worse in men. 6 The follow-up challenges were a major determinant of clinical outcome but the effect on HRQoL remains largely unknown. HRQoL scores for cancer patients are generally low but comparatively better in patients with limited metastases.…”

Section: Introductionmentioning

confidence: 99%

Drug therapy problems and health related quality of life among patients with colorectal cancer in a Kenyan tertiary health facility

Kabiru¹,

Karimi

Nyamu

et al. 2020

J Oncol Pharm Pract

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Background Colorectal cancer is the third most common form of cancer in males and the second in females globally. The ill-health due to cancer and use of multiple therapies may result in drug related problems and also affect the health-related quality of life of the patients. Objective To characterize drug therapy problems and health-related quality of life among patients with colorectal cancer at Kenyatta National Hospital. Methodology: A descriptive prospective cross-sectional study design was used and simple random sampling utilized to select seventy- one participants. The participants were interviewed and their responses captured using World Health Organisation Quality of Life-BREF and a structured questionnaire. The data were analysed using STATA version 15.0. Data was summarized using descriptive statistic such as mean, range and standard deviation. Association between variables was determined using linear regression model at 0.05% level of significance. Ethical approval was granted by the relevant authorities to conduct the study. Results Patients were predominantly females (52.1%), had a mean age of 55.9± 14.4 years. The main drug therapy problems were adverse drug reactions (45.1%). Approximately two thirds (67.6%) of the participants complained of gastrointestinal problems followed by cardiovascular diseases (29.6%). Quality of life assessment indicated that psychological health had the highest score at 60.5%. On linear regression analysis, the presence of anemia ( p = 0.021), coverage ( p = 0.038), and cardiovascular problems ( p = 0.034) were significantly associated with the overall health-related quality of life. Conclusion The health-related quality of life was is dependent on several patient related factors. Interventions regarding prevention of drug therapy problems should be considered alongside other measures used to manage colorectal cancer.

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Clinical Outcomes of Colorectal Cancer in Kenya

Cited by 9 publications

References 1 publication

Colorectal Adenocarcinoma in East Africa: A Narrative Literature Review

Colorectal Adenocarcinoma in East Africa: A Narrative Literature Review

Prognostic Factors for Survival of Colorectal Adenocarcinoma Patients in Uganda

Drug therapy problems and health related quality of life among patients with colorectal cancer in a Kenyan tertiary health facility

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