Clinical Outcomes of Covid-19 in Patients With Liver Cirrhosis - A Propensity-Matched Analysis From a Multicentric Brazilian Cohort

Abstract

Background Cirrhosis has been pointed out as a clinical entity that leads to worse clinical prognosis in COVID-19 patients. However, this concept is controversial in the literature. We aimed to evaluate clinical outcomes by comparing patients with cirrhosis to those without cirrhosis in a Brazilian cohort. Methods Data from 20,164 COVID-19 inpatients were collected from 41 hospitals in Brazil between March to September 2020 and March 2021 to August 2022. We compared 117 patients with cirrhosis to 632 matched controls. A propensity score model was used to adjust for potential confounding variables, incorporating some predictors: age, sex at birth, number of comorbidities, hospital of admission, whether it was an in-hospital clinical manifestation of COVID-19 and admission year. Closeness was defined as being within 0.16 standard deviations of the logit of the propensity score. Results The median age was 61 (IQR 50–70) years-old, and 63.4% were men. There were no significant differences in the self-reported symptoms. Patients with cirrhosis had lower median hemoglobin levels (10.8 vs 13.1 g/dl), lower platelets (127,000 vs 200,000 cells/mm3), and leukocytes counts, as well as lower median C-reactive protein (63.0 vs 76.0 p = 0.044) when compared to controls.They also had had higher mortality compared to matched controls (51.3% vs 21.7%, p < 0.001). They also had higher frequencies of admission in an intensive care unit (51.3% vs 38.0%, p = 0.007), invasive mechanical ventilation (43.9% vs 26.6%, p < 0.001), dialysis (17.9% vs 11.1%, p = 0.038), septic shock (23.9% vs 14.9%; p = 0.015) and institution of palliative care (19.7% vs 7.4%; p < 0.001). Conclusions This study has shown that COVID-19 inpatients with cirrhosis had significantly higher incidence of severe outcomes, as well as higher frequency of institution of palliative care when compared to matched controls. Our findings underscore the need for these patients to receive particular attention from healthcare teams and allocated resources.