Clinical outcomes of COVID-19 infection in congenital heart disease: A single-center experience in Indonesia

Siagian, Sisca Natalia; Oetama, Susandy; Pohan, Fathy Zuandi; Mendel, Brian; Lelya, Olfi; Sakti, Damba Dwisepto Aulia; Kurniawati, Yovi

doi:10.3389/fcvm.2022.1022183

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…Another interesting nding in this study was the recurrence of SARS-CoV-2 after surgeries, which was not reported by previous CHD reports [16,17,21,22]. The recurrence rate was as high as 20% (8/40), and all recurrences were detected by re-positive nucleic acid tests on the day of surgery after patients were admitted to the ICU.…”

Section: Discussioncontrasting

confidence: 43%

Surgical outcomes in children with congenital heart disease after SARS-CoV-2 Omicron variant infection: a single-center case-control study

Yang,

Yu,

Huang

et al. 2023

Preprint

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Objective To analyze the clinical characteristics and surgical outcomes in children with congenital heart disease (CHD) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant infection. Methods A retrospective case‒control study was performed on children with CHD after SARS-CoV-2 Omicron variant infection as a convalescent group at Shanghai Children's Medical Center from Jan 1,2022 to Jan 20,2023. The control group was matched by CHD patients (without SARS-CoV-2 infection) who underwent surgical repair during the same period. Clinical data and outcomes were analyzed and compared between groups. Result A total of 120 CHD patients were included in this study: 40 CHD patients after SARS-CoV-2 infection (convalescent group) and 80 CHD patients without infection (control group). The in-hospital mortality rate was 2.5% (1/40) in the convalescent group. Troponin I values were statistically higher in convalescent group than in control at surgery day after being admitted to intensive care unit(ICU) [6.98 (3.43–14.79)vs. 2.67 (1.38–6.22),p = 0.00] and postsurgery day 1[2.69 (1.17–5.05)vs. 1.56 (0.73–3.40), p = 0.015]. In addition, patients who undergo surgery within 10 days of a negative nucleic acid results (NNAR) were associated with prolonged ICU stay(4.57 ± 3.01 vs 3.06 ± 1.52, p = 0.046). The recurrence rate of SARS-CoV-2 was 20% (8/40) in this study. The cardiopulmonary bypass (CPB) time [98.5 (64.75-289.25) vs. 64.5 (48.5–88), p = 0.010] in recurrence patients was longer than that in patients without recurrence. Moreover, patients with recurrence were associated with longer mechanical ventilation time (72.00 ± 57.32 vs. 21.78 ± 17.83, 0.043) and ICU stay (6.75 ± 3.54 vs. 3.25 ± 1.72, p = 0.027). Conclusion In children with CHD after SARS-CoV-2 Omicron variant infection, myocardial injury after surgery might be more severe. Clinical outcome was without statistical difference if surgeries were performed after 10 days of NNAR. Patients with longer CPB times were likely to suffer recurrence after surgery which may lead to longer MV and ICU time.

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Section: Discussioncontrasting

confidence: 43%

Surgical outcomes in children with congenital heart disease after SARS-CoV-2 Omicron variant infection: a single-center case-control study

Yang,

Yu,

Huang

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Congenital heart disease (CHD) is prevalent in 1% of the population [ 20 ]. These children are at increased risk for complications from respiratory viral infections, including influenza and respiratory syncytial virus (RSV) [ 21 , 22 ], but there are only limited data on complications associated with COVID-19 infection among children with CHD [ 2 , 23 , 24 ]. Here, we report an analysis from a recent nationwide cross-sectional retrospective study based on the United States National Inpatient Sample (NIS) database to examine mortality risks and in-hospital cardiovascular and non-cardiovascular complications as a result of COVID-19 infection among children with CHD.…”

Section: Introductionmentioning

confidence: 99%

Impact of congenital heart disease on outcomes among pediatric patients hospitalized for COVID-19 infection

et al. 2023

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Background COVID-19 infection is generally regarded as an acute self-limiting illness in children, but it can cause significant morbidity and mortality in both healthy and high-risk children. There are limited data on the outcomes of children with congenital heart disease (CHD) and COVID-19. This study aimed to examine the risks of mortality, in-hospital cardiovascular and non-cardiovascular complications in this patient population. Methods We analyzed data from hospitalized pediatric patients from 2020 using the nationally representative National Inpatient Sample (NIS). Children hospitalized for COVID-19 were included, and weighted data were used to compare in-hospital mortality and morbidities between children with and without CHD. Results Out of 36,690 children admitted with a diagnosis of COVID-19 infection(ICD-10 code:U07.1 and B97.29) during calendar year 2020, 1240 (3.4%) had CHD. The risk of mortality in children with CHD was not significantly higher than those without CHD(1.2% vs. 0.8%, p = 0.50), with adjusted OR (aOR) of 1.7 (95% CI: 0.6–5.3). Tachyarrhythmias and heart block were more likely in CHD children with an aOR of 4.2 (95% CI: 1.8–9.9) and aOR of 5.0 (95% CI: 2.4–10.8), respectively. Similarly, respiratory failure [aOR = 2.0 (1.5–2.8)], respiratory failure requiring non-invasive mechanical ventilation [aOR = 2.7 (1.4–5.2)] and invasive mechanical ventilation [aOR = 2.6 (1.6-4.0)], and acute kidney injury [aOR = 3.4 (2.2–5.4)] were all significantly higher among patients with CHD. Median length of hospital stay in children with CHD was longer than those without CHD [5 days (IQR: 2–11) vs. 3 days (IQR: 2–5), p = < 0.001]. Conclusions Children with CHD hospitalized with COVID-19 infection were at increased risk of serious cardiovascular and non-cardiovascular adverse clinical outcomes. They also had increased length of hospital stay and utilization of healthcare resources.

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“…[20] These children are at increased risk for complications from respiratory viral infections, including in uenza and respiratory syncytial virus (RSV) [21,22], but there are only limited data on complications associated with COVID-19 infection among children with CHD. [2,23,24] Here, we report an analysis from a recent nationwide cross-sectional retrospective study based on the United States National Inpatient Sample (NIS) database to examine mortality risks and in-hospital cardiovascular and non-cardiovascular complications as a result of COVID-19 infection among children with CHD.…”

mentioning

confidence: 99%

Impact of congenital heart disease on outcomes among pediatric patients hospitalized for COVID-19 infection

Ghimire

Chou

Aljohani

et al. 2023

Preprint

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Background COVID-19 infection is generally regarded as an acute self-limiting illness in children, but it can cause significant morbidity and mortality in both healthy and high-risk children. There are limited data on the outcomes of children with congenital heart disease (CHD) and COVID-19. This study aimed to examine the risks of mortality, in-hospital cardiovascular and non-cardiovascular complications in this patient population. Methods We analyzed data from hospitalized pediatric patients from 2020 using the nationally representative National Inpatient Sample (NIS). Children hospitalized for COVID-19 were included, and weighted data were used to compare in-hospital mortality and morbidities between children with and without CHD. Results Out of 33,220 children admitted with a diagnosis of COVID-19 infection(ICD-10 code:U07.1) during calendar year 2020, 875 (2.6%) had CHD. Compared to children without CHD, children with CHD had similar in-hospital mortality (1.2% vs 0.8%, p = 0.63), with adjusted OR (aOR) of 2.0 (95% CI: 0.5–8.3). Tachyarrhythmias and heart block were more likely in CHD children with an aOR of 4.9 (95% CI: 1.9–12.4) and aOR of 4.4 (95% CI: 2.0-9.7), respectively. Similarly, respiratory failure [aOR = 1.8 (1.2–2.9)], respiratory failure requiring non-invasive mechanical ventilation [aOR = 3.1 (1.5–6.2)] and invasive mechanical ventilation [aOR = 2.2 (1.2-4.0)], and acute kidney injury [aOR = 3.0 (1.8–4.9)] were all significantly higher among patients with CHD. Median length of hospital stay in children with CHD was longer than those without CHD [5 days (IQR: 2-9.3) vs. 3 days (IQR: 2–5), p = < 0.001]. Conclusions Children with CHD hospitalized with COVID-19 infection were at increased risk of serious cardiovascular and non-cardiovascular adverse clinical outcomes. They were not at increased risk for death when compared to children without CHD but had increased length of hospital stay and utilization of healthcare resources.

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Clinical outcomes of COVID-19 infection in congenital heart disease: A single-center experience in Indonesia

Cited by 3 publications

References 40 publications

Surgical outcomes in children with congenital heart disease after SARS-CoV-2 Omicron variant infection: a single-center case-control study

Surgical outcomes in children with congenital heart disease after SARS-CoV-2 Omicron variant infection: a single-center case-control study

Impact of congenital heart disease on outcomes among pediatric patients hospitalized for COVID-19 infection

Impact of congenital heart disease on outcomes among pediatric patients hospitalized for COVID-19 infection

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