Clinical Outcomes of Daptomycin Versus Anti-Staphylococcal Beta-Lactams in Definitive Treatment of Methicillin-susceptible Staphylococcus aureus Bloodstream Infections

Agnello, Sydney; Wardlow, Lynn; Reed, Erica E; Smith, Jessica M.; Coe, Kelci E; Day, Shandra R.

doi:10.1016/j.ijantimicag.2021.106363

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…Nafcillin is semisynthetic penicillin used as an initial line of defence against S. aureus infection. [47] The presence of aryl-alkyl group and many oxygen heteroatoms in the drug show structural similarity to the ligand 4 a synthesized in the present work. Owing to this, the computational technique of molecular docking was used to predict the binding pose and affinity of 4 a to bacterial protein (PDB ID: 8H1B).…”

Section: Molecular Dockingmentioning

confidence: 53%

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Singh,

Thakur,

Priyanka

et al. 2024

ChemistrySelect

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Chromium is known to play an important role in various metabolic pathways; however, its excessive use can result in negative impact on mankind, this necessitates the development of sensors for Cr(III) ion. The current study has incorporated the synthesis of ether derived Schiff base allied silanes 4 a–4 d, which have been characterized using 1H NMR, 13C NMR and mass spectrometry. The spectroscopic technique of UV‐visible has been utilized to study the sensing behaviour of probe 4 a, resulting in a good sensing ability towards Cr(III) ion, yielding a detection limit of 4.2×10−7 M and an association constant value of 2.25×106 M−1. In order to study the stoichiometric binding between probe and metal ion, Job's plot method has been employed which shows 1 : 1 binding ratio. The mechanism of binding has been studied via 1H NMR, UV‐visible, FT‐IR spectroscopy and mass spectrometry. The binding has been further supported by DFT. The real sample analysis has been performed to validate the utility of the synthesized sensor in practical applications. The theoretical tool of molecular docking has been considered to study the protein‐ligand interaction between S. aureus bacterial protein and ligand 4 a, yielding a value of −7.63 kcal/mol for binding energy.

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Section: Molecular Dockingmentioning

confidence: 53%

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Singh,

Thakur,

Priyanka

et al. 2024

ChemistrySelect

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“…42 Our findings support the 2023 European Society of Cardiology guidelines for endocarditis treatment, which state that clinicians should administer this drug with another antistaphylococcal antibiotic to lower the chances of treatment failure. 37 Moreover, although clinical outcomes are similar between MSSA bacteremia patients treated with daptomycin and antistaphylococcal penicillins, 43 clinicians should consider the increased risk associated with daptomycin cross-resistance. The lines also consistently responded to clindamycin.…”

Section: Discussionmentioning

confidence: 99%

The evolution of diverse antimicrobial responses in vancomycin-intermediateStaphylococcus aureusand its therapeutic implications

Crozier,

Gray,

Maltas

et al. 2023

Preprint

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Staphylococcus aureuscauses serious clinical infections, including bacteremia and endocarditis. When clinicians suspect these diseases, they prescribe broad-spectrum antibiotics like vancomycin and then adjust treatment based on antimicrobial susceptibility test results. However, these results reflect the infection’s state before treatment and do not account for any potential changes in its antibiotic response arising from intervening evolution. Thus, an initial test may indicate that the infection is susceptible to a particular drug, but this recommendation may be tentative. In this study, we aimed to understand how treatment effectiveness changes over time by accounting for evolution. First, we evolved 18 methicillin-susceptibleS. aureus(MSSA) populations under increasing vancomycin concentrations until they reached intermediate resistance levels. We then sequenced their complete genomes to characterize the mutational paths to their evolved vancomycin-intermediate states. Lastly, we subjected these evolved populations to seven antibiotics used to treat MSSA infections and compared drug susceptibilities between the evolved lines and their common ancestor. Mutations in several genes responsible for regulating the cell membrane stress response and cell-wall biosynthesis appeared in parallel among the evolved vancomycin-intermediateS. aureus(VISA) populations, and these lines were repeatedly cross-resistant to daptomycin. These observations align with previous clinical findings, reinforcing the role of these genes in mediating resistance. In contrast, the populations exhibited diverse responses to other antibiotics. Most lines were susceptible to meropenem, gentamicin, and nafcillin, but several replicates were also resistant. We accounted for this diversity by deriving likelihood estimates that express a population’s probability of exhibiting a drug response following vancomycin treatment. Our findings support using antistaphylococcal penicillins (e.g., nafcillin) as a first-line treatment for MSSA, even in light of intermediate vancomycin resistance. They also emphasize the inherent uncertainty and risk that evolution poses to effective therapies, attributes one cannot account for by susceptibility tests alone. Instead, clinicians must consider infections as evolving systems that may take several different paths, with implications on their potential sensitivities to other drugs.

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“…The utility of daptomycin in combination with other β-lactams is intriguing given the efficacy daptomycin compared with antistaphylococcal therapy. 55 Grillo and colleagues 64 described their experience with a retrospective cohort study. Patients were classified not only by antimicrobial regimen but also by source of infection, with infective endocarditis and unknown sources of infection being classified as high risk, whereas osteoarticular, skin and soft tissue, urinary, and vascular sources being classified as low-intermediate risk.…”

Section: Novel Combination Therapiesmentioning

confidence: 99%

“…Ultimately, this study showed that there are in vivo consequences of the in vitro inoculum effect displayed by some MSSA strains. Agnello and colleagues 55 performed a single-center retrospective cohort study to assess the clinical outcomes of daptomycin to antistaphylococcal β-lactams (cefazolin or nafcillin) in MSSA bacteremia. As highlighted in Table 1, there was no statistical difference between the daptomycin and the β-lactam cohorts in the primary composite outcome of clinical failure, recurrence or persistence, and infection-related mortality.…”

Section: Study Selection/data Extractionmentioning

confidence: 99%

Therapeutic Options for Adult Patients With Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Narrative Review

Chastain

Covert

et al. 2023

Ann Pharmacother

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Objective: To compare the efficacy of antimicrobial therapies used in the management of persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia. Data Sources: A literature search using the PubMed database (inception to December 2022) was conducted using the search terms “ Staphylococcus aureus bacteremia,” “methicillin-susceptible Staphylococcus aureus bacteremia,” “persistent methicillin-susceptible Staphylococcus aureus bacteremia,” and “refractory methicillin-susceptible Staphylococcus aureus bacteremia .” In addition, therapeutic agents which could be used as treatment for MSSA including “nafcillin,” “oxacillin,” “cefazolin,” “ceftaroline,” “gentamicin,” “rifampin,” and “daptomycin” were also combined with the aforementioned search terms to capture data using these agents. Study Selection/Data Extraction: Clinical data were limited to those published in the English language. Articles and abstracts were considered for inclusion in addition to ongoing trials identified through ClinicalTrials.gov. Data Synthesis: A total of 78 articles were reviewed including 17 in vitro or animal model studies and 39 studies including patient data. The remaining 22 articles included guidelines, review articles, and editorials. Recent data evaluating use of dual β-lactam regimens for persistent MSSA bacteremia were limited to 8 case reports or case series. Relevance to Patient Care and Clinical Practice: At present, there is little guidance on how to best manage patients with persistent MSSA bacteremia. This narrative review collates the available data to assist clinicians in selecting the best possible antimicrobial regimen when facing this clinical conundrum. Conclusions: Modification of antimicrobial therapy, in conjunction with source control and infectious diseases consultation, may all be necessary to sterilize blood cultures in patients with persistent MSSA bacteremia.

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Clinical Outcomes of Daptomycin Versus Anti-Staphylococcal Beta-Lactams in Definitive Treatment of Methicillin-susceptible Staphylococcus aureus Bloodstream Infections

Cited by 6 publications

References 16 publications

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

Synthesis of Schiff‐Base Allied Silanes for the Photophysical Detection of Cr(III) Ion And In‐Silico Staphylococcus Aureus Inhibiting Activity

The evolution of diverse antimicrobial responses in vancomycin-intermediateStaphylococcus aureusand its therapeutic implications

Therapeutic Options for Adult Patients With Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia: A Narrative Review

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