Clinical outcomes of different treatments and risk factors in patients with otogenic brain abscess, a real-world evidence-based retrospective study

Song, Yao; Cheng, Danni; Qiu, Ke; Yan, Xiaohong; Ren, Jianjun; Qiu, Jianqing; Deng, Di; Rao, Yufang; Zheng, Yongbo; Pang, Wendu; Dong, Yijun; Liu, Qiurui; Ren, Yanming; Zhao, Yu

doi:10.1080/00016489.2020.1800088

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Insiden abses otak sekitar 8% dari massa intrakranial di negaranegara berkembang (Muzumdar et al, 2011). insiden komplikasi intrakranial sekarang hanya 0,02-1,97% (Song et al, 2020). Abses otak otogenik adalah abses otak yang terjadi sekunder akibat infeksi telinga atau mastoiditis (Burton et al, 2019).…”

Section: Pendahuluanunclassified

“…Mortalitas dan morbiditas sepsis intracranial telah menurun dengan munculnya tomografi komputer, magnet pencitraan resonansi, teknik bedah yang lebih baik, dan perkembangan antibiotic, dari 30-60% sebelumnya tahun 1970-an menjadi <10% (Yakobi et al, 2019). Angka kematian pasien OBA adalah 8-26,3% (Song et al, 2020). Kegagalan tatalaksana OMSK dengan komplikasi abses otak biasanya berhubungan dengan aspirasi abses yang tidak adekuat, kurangnya drainase melalui kateter, kondisi imunosupresi kronik, dan terapi antibiotik yang kurang memadai (Muzumdar et al, 2011).…”

Section: Pendahuluanunclassified

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Case Report: Management of Chronic Supurative Otitis Media Cholesteatoma Type with Recurrent Brain Abscess Complication

Ikhlas

Edward

2022

AMS

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Introduction: Chronic suppurative otitis media is broadly defined as chronic inflammation that involved mucose of middle ear and mastoid air cells. The most commonly encountered intracranial complication from chronic suppurative otitis media is meningitis followed by brain abscess. Antibiotics are quite effective in early and late cerebritis stage. Surgical intervention is essential once the abscess’s capsule is formed. Case Report: Reported a case of a 22-year-old male diagnosed with chronic suppurative otitis media auris dextra suspected cholesteatoma type with cerebral abscess complications. The managements are cerebral abscess drainage followed by canal wall down mastoidectomy. In patient, Recurrent cerebral abscess formed. Conclusion: Chronic suppurative otitis media with complications of cerebral abscess is treated with abscess drainage if the abscess size is >2cm and followed by canal wall down mastoidectomy. Otogenic brain abscess due to chronic suppurative otitis media can occur repeatedly if abscess antibiotic therapy was/were inadequate Keywords: otogenic brain abscess, mastoidectomy, chronic suppurative otitis media, abscess drainage

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Section: Pendahuluanunclassified

Case Report: Management of Chronic Supurative Otitis Media Cholesteatoma Type with Recurrent Brain Abscess Complication

Ikhlas

Edward

2022

AMS

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“…Recent studies also showed a higher incidence of brain abscess of odontogenic origin than previously reported in the literature, up to 14% in adults and 22% in children [5,6 & ]. Likewise, the ENT area remains an important source of infection [7,8].…”

Section: Key Pointsmentioning

confidence: 99%

Brain abscess in immunocompetent patients: recent findings

Thy

Gaudemer²,

d’Humières

et al. 2022

Current Opinion in Infectious Diseases

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Purpose of reviewWe conducted a systematic review of the literature to update findings on the epidemiology and the management of cerebral abscesses in immunocompetent patients.Recent findingsObservational studies suggest that the overall prognosis has improved over the last decades but mortality rates remain high. Several parameters may contribute to a better prognosis, including the identification of common risk factors for brain abscess, the systematic use of brain MRI at diagnosis, the implementation of appropriate neurosurgical and microbiological techniques for diagnosis, the optimization of the antibacterial treatment based on epidemiology and pharmacokinetic/pharmacodynamic studies, and a long-term follow-up for detection of secondary complications. Outcome research on brain abscess is mainly based on observational studies. Randomized controlled trials have yet to be performed to identify clinically relevant interventions associated with improved patient-centered outcomes.SummaryOur review highlights the importance of a multidisciplinary approach to optimize brain abscess management both at the acute phase and in the long-term. Randomized controlled studies are urgently needed to identify interventions associated with improved outcomes.

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Otogenic brain complications: a systematic review and meta-analysis

Gkrinia,

Brotis,

Vallianou

et al. 2024

J. Laryngol. Otol.

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Objective This study aimed to form astute deductions regarding the presentation, treatment and mortality of otogenic brain complications. Methods A systematic literature search of four medical databases (PubMed, Embase, Web of Science and Scopus) was conducted. Studies associated with otogenic brain complications were considered eligible. Fixed- and random-effects model meta-analysis was developed to assess the proportion estimate for each outcome individually. Results Twenty-eight studies, with 1650 patients in total, were included. In 66 per cent of patients there was a known history of chronic otitis media. The most common symptoms were purulent otorrhoea (84 per cent), headache (65 per cent) and otalgia (45 per cent). A brain abscess was observed in 49 per cent of patients, followed by meningitis (34 per cent) and sinus thrombosis (22 per cent). A combination of surgical and conservative therapy was chosen in 84.3 per cent of cases and the mortality rate approached 11.1 per cent. Conclusion Otogenic brain complications are a possibly life-threatening condition. Prompt imaging examination may set the final diagnosis and lead to an effective treatment.

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Clinical outcomes of different treatments and risk factors in patients with otogenic brain abscess, a real-world evidence-based retrospective study

Cited by 3 publications

References 19 publications

Case Report: Management of Chronic Supurative Otitis Media Cholesteatoma Type with Recurrent Brain Abscess Complication

Case Report: Management of Chronic Supurative Otitis Media Cholesteatoma Type with Recurrent Brain Abscess Complication

Brain abscess in immunocompetent patients: recent findings

Otogenic brain complications: a systematic review and meta-analysis

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