Clinical Outcomes of Multicenter Domino Kidney Paired Donation

Lee, Y. J.; Lee, S. U.; Chung, Sang Young; Cho, B. H.; Kwak, J. Y.; Kang, Chong Myung; Park, J. T.; Han, Duck Jong; Kim, D. J.

doi:10.1111/j.1600-6143.2009.02747.x

Cited by 20 publications

(17 citation statements)

References 21 publications

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“…The South Korean and Dutch groups have reported only domino chains that had no bridge donors and were designed to be kept short to avoid potential reneges. Additionally, their donors traveled to the recipients centers rather than the grafts being shipped (16,23).…”

Section: Discussionmentioning

confidence: 99%

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Chain Transplantation: Initial Experience of a Large Multicenter Program

Melcher

Leeser

Gritsch³

et al. 2012

American Journal of Transplantation

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We report the results of a large series of chain transplantations that were facilitated by a multicenter US database in which 57 centers pooled incompatible donor/recipient pairs. Chains, initiated by nondirected donors, were identified using a computer algorithm incorporating virtual cross-matches and potential to extend chains. The first 54 chains facilitated 272 kidney transplants (mean chain length = 5.0). Seven chains ended because potential donors became unavailable to donate after their recipient received a kidney; however, every recipient whose intended donor donated was transplanted. The remaining 47 chains were eventually closed by having the last donor donate to the waiting list. Of the 272 chain recipients 46% were ethnic minorities and 63% of grafts were shipped from other centers. The number of blood type O-patients receiving a transplant (n = 90) was greater than the number of blood type O-non-directed donors (n = 32) initiating chains. We have 1-year follow up on the first 100 transplants. The mean 1-year creatinine of the first 100 transplants from this series was 1.3 mg/dL. Chain transplantation enables many recipients with immunologically incompatible donors to be transplanted with high quality grafts.

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Section: Discussionmentioning

confidence: 99%

“…Simulations from the United States and reports from Korea and the Netherlands have not fully addressed these concerns (3,16,17). We report the experience of the first 54 chains involving 272 kidney transplants that were orchestrated by a multicenter registry using an exhaustive search algorithm to identify potential matches.…”

Section: Introductionmentioning

confidence: 99%

Chain Transplantation: Initial Experience of a Large Multicenter Program

Melcher

Leeser

Gritsch³

et al. 2012

American Journal of Transplantation

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“…The median wait time between enrollment and transplantation was 13 months. Oneyear and 5-year graft survival rates were 98.3 % and 87.7 %, respectively, with a median follow-up of 46 months [33].…”

Section: South Koreamentioning

confidence: 94%

“…16 centres participated and between 2001 and 2007; 179 transplants were performed with 70 domino chains initiated by NDD. The mean age of NDD was 43.7±8.8 (range, 37-50 years), with many (28 %) in a religious profession [33]. In addition, there were 45 two-pair chains, 15 three-pair chains, 7 four-pair chains, 2 five-pair chains and 1 six-pair chain.…”

Section: South Koreamentioning

confidence: 99%

State of the Art Practices and Policies in Kidney Paired Donation

Malik

Cole

2013

Curr Transpl Rep

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Approximately one-third of kidney transplant candidates have medically acceptable living donors, but are unable to receive transplants due to donor-recipient incompatibilities. Kidney paired donation (KPD) is a strategy that matches incompatible pairs in order to find compatible matches, thus increasing living donor transplantation. The concept was first conceived in 1986. Since then, significant strides have been made. However, the technique remains underutilized. This article describes the current advances, types of paired donation programmes, registries, worldwide experience, outcomes, barriers, and limitations.

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“…In practice, individuals who donate to a stranger often express dissatisfaction or discomfort with the term 'Good Samaritan'. There is also mixed evidence regarding religion as a driving force behind donation to a stranger (6,9,12,(18)(19)(20). In most religions, organ donation during life is considered a supremely generous and ennobling act (21,22).…”

Section: Good Samaritanmentioning

confidence: 99%