Clinical Outcomes of Penetrating Keratoplasty After Autologous Cultivated Limbal Epithelial Transplantation for Ocular Surface Burns

Safety outcomes and long-term effectiveness of ex vivo autologous cultured limbal epithelial transplantation for limbal stem cell deficiency

“…This is not completely new, as Rama et al 14 reported episodes of corneal graft rejection in about 50% of patients after PK on successful CLET, and Basu et al 34 showed that failure of PK after autologous CLET occurred in about 58% of eyes as a result of corneal graft rejection.…”

Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency

“…Miri et al estimated in 2010 that, in the UK, a single CLET procedure cost approximately £10 300 (or about €12 000) 18. Despite having successfully performed over 500 CLET procedures for the treatment of LSCD since 2001,15 19 we felt that, in reality, CLET has become restricted to only a handful of advanced centres worldwide because of these limitations. Similarly, CLAU has also failed to garner universal acceptance because of the perceived risk of donor site complications.…”

Successful management of severe unilateral chemical burns in children using simple limbal epithelial transplantation (SLET)

“…Case 3 is awaiting penetrating keratoplasty (PKP) for a dense corneal scar. It was not performed along with SLET due to reports of poorer clinical outcomes of single-stage surgery (CLET with PKP) than a two-stage approach 29. Although Case 4 had maximum improvement in visual acuity (6/18), it was limited due to anterior corneal scar and may be considered for anterior lamellar keratoplasty in future.…”