Clinical outcomes of prestripped, prestained, and preloaded Descemet's membrane endothelial keratoplasty (“P3 DMEK”)

Abstract

PURPOSE: Despite faster healing and reduced risk of rejection, some surgeons are hesitant to adopt Descemet membrane endothelial keratoplasty (DMEK) due to difficult intraoperative tissue preparation. Use of eye bank prestripped, prestained, and preloaded (p 3 ) DMEK tissue can reduce the learning curve and risk of complications. MATERIALS AND METHODS: We conducted a prospective study including 167 eyes undergoing p 3 DMEK and compared outcomes to a retrospective chart review of 201 eyes that underwent standard DMEK surgery. The primary outcomes were graft failure, detachment, and re-bubbling frequency. The secondary outcomes included baseline and postoperative visual acuity at months 1, 3, 6, and 12. Baseline and postoperative central corneal thickness (CCT) and endothelial cell counts (ECC) were collected. RESULTS: ECC decrease for p 3 DMEK at 3, 6, and 12 months were 15.0%, 18.0%, and 21.0%, respectively. Forty (24%) of p 3 DMEK and 72 (35.8%) of standard DMEK eyes had at least a partial graft detachment. There was no difference in CCT, graft failures, or re-bubble frequency. At 6 months, mean visual acuity was 20/26 and 20/24 for standard and p 3 DMEK, respectively. Mean case time for p 3 DMEK with phaco or p 3 DMEK alone was 33 and 24 min, respectively. Mean case time for eyes undergoing DMEK with phaco or DMEK alone was 59 and 45 min, respectively. CONCLUSION: P 3 DMEK tissue is safe and can provide excellent clinical outcomes that are comparable to standard DMEK tissue. Eyes undergoing p 3 DMEK may have lower graft detachment and ECC loss.

Advancing beyond our recent advances in ocular surface disease and corneal surgery

“…Juratli et al . [ 4 ] present their clinical outcomes of prestripped, prestained, and preloaded DMEK tissue (”P3 DMEK”), demonstrating excellent outcomes that are comparable to traditional DMEK preparation techniques. As surgeons have become more comfortable with these newer surgical techniques, the indications for use have become broader, and situations in which early surgeons would avoid for DMEK are now acceptable indications for which to perform the procedure.…”