Clinical Outcomes of Radiotherapy in Elderly and Younger Patients With T4 Esophageal Cancer: A Retrospective Single-center Analysis

Abstract

Background/Aim: The standard of treatment for esophageal cancer with adjacent organ invasion (T4) has not been established. We retrospectively analyzed the clinical outcomes of radiotherapy (RT) in elderly and younger patients with T4 esophageal cancer. Patients and Methods: Sixty-nine patients with T4 esophageal cancer who underwent RT at the Kanagawa Cancer Center between January 2014 and November 2020 were included in this study. Patients aged ≥70 years were defined as the elderly group and those aged <70 years were defined as the younger group. The total dose of RT was set at 60 Gy in 30 fractions. Chemotherapy combined with 5-fluorouracil and cisplatin was administered concurrently with RT in general. The overall survival (OS) rate was estimated using the Kaplan-Meier method. Adverse events were assessed using CTCAE v4.0. Results: The median survival time (MST) of the elderly group (n=35) was 21.5 months, and the OS rates at 1, 3, and 5 years were 63.7%, 31.3%, and 15.6%, respectively. The MST of the younger group (n=34) was 12.5 months, and the OS rates at 1, 3, and 5 years were 52.2%, 29.4%, and 29.4%, respectively. No significant difference in OS was observed between the two groups (p=0.767). Toxicities were not significantly different between the two groups except for thrombocytopenia and esophageal fistula (p=0.012 and p=0.022, respectively). Conclusion: The clinical outcomes of RT for T4 esophageal cancer in elderly patients were generally similar to those in the younger group.

Multi-omics and Multi-VOIs to predict esophageal fistula in esophageal cancer patients treated with radiotherapy

“…Despite advances in these treatment regimens, the overall survival rate remains poor (Kelly 2019 ; Watanabe et al 2020 ; Ajani et al 2019 ; Ilson 2021 ; Salmanpour et al 2023a , b). Most EC patients are diagnosed at an advanced stage, often accompanied by T4, which makes radical esophagectomy almost inapplicable(Takakusagi et al 2022 ). Research shows that radiotherapy-based treatment plays an essential role in unresectable EC patients, with concurrent chemoradiotherapy (CCRT) or sequential chemoradiotherapy (SRT) and adjuvant or individual radiotherapy (RT) being common clinical approaches (Kakeji et al 2021 ; Mönig et al 2018 ; Zhang et al 2018a ).…”