Clinical outcomes of retrograde intra-arterial chemotherapy concurrent with radiotherapy for elderly oral squamous cell carcinoma patients aged over 80 years old

Abstract

BackgroundThe aim of this retrospective observational study was to evaluate toxicities, overall survival, and locoregional control in elderly oral squamous cell carcinoma patients who had undergone retrograde intra-arterial chemotherapy combined with radiotherapy.MethodsThirty-one elderly patients over 80 years old with oral squamous cell carcinoma were enrolled in present study. The treatment schedule consisted of intra- arterial chemotherapy (docetaxel, total 60 mg/m2; cisplatin, total 150 mg/m2) and daily concurrent radiotherapy (total, 60 Gy) for 6 weeks.ResultsThe median patient age was 82.5 years old (range, 80–88 years). Of the 31 patients, six (19%) had stage II, 6 (19%) had stage III, 17 (55%) had stage IVA, and 2 (6%) had stage IVB. The median follow-up period for all patients was 37 months (range, 7–86 months). The 3-year overall survival and locoregional control rates were 78% and 81%, respectively. The major acute grade 3 adverse events were oral mucositis in 22 (71%) patients, neutropenia in 16 (52%), and dermatitis in 11 (35%). With respect to late toxicities, 1 patient (3%) developed grade 3 osteoradionecrosis of the jaw. No grade 4 or higher toxicities were observed during the treatment and follow-up periods.ConclusionsRetrograde intra-arterial chemotherapy combined with radiotherapy was effective in improving overall survival and locoregional control even for elderly patients.

Effect of verbascoside on apoptosis and metastasis in human oral squamous cell carcinoma

“…Definitive concurrent chemoradiotherapy is considered standard of care for inoperable locoregionally advanced OSCC . DDP is the most common chemotherapeutic agent used in combination with radiotherapy in the treatment of OSCC . However, DDP has severe side effects such as nephrotoxicity .…”

“…31 DDP is the most common chemotherapeutic agent used in combination with radiotherapy in the treatment of OSCC. 32 However, DDP has severe side effects such as nephrotoxicity. 33 Therefore, the development of new therapeutic methods of high curative value as well as low toxicity and side effects, especially for patients with advanced OSCC, is needed.…”

Interventional Management of Head and Neck Tumors

“…59 Chemoradiation treatment has thus emerged as an alternative to surgery for the patients with advanced disease, with favorable rates of locoregional control and survival. 60,61 Cisplatin alone or in conjunction with taxols is usually used as part of concurrent chemoradiation treatment regimens. 62,63 Dose-limiting renal and gastrointestinal toxicity occurs above conventional systemically administered cisplatin doses ($125 mg/m 2 ).…”

Idosos mais idosos: uma revisão da literatura

“…Estudo com pacientes muito idosos para tratar câncer colorretal (Ip, 2017;Fakhry, et al, 2013;Hayashi, et al, 2017;Laribi, et al, 2016;Park, et al, 2016;Rinaldi, et al, 2017;Tokushige, Hashimoto, Horie, Taniai, & Higuchi, 2014;e Varga, et al, 2014). Esses dados justificam, em parte, os achados no que diz respeito aos estudos sobre intervenção medicamentosa, tendo em vista que, em sua maioria, tratavam-se de quimioterápicos (Ip, 2017;Hayashi, et al, 2017;Laribi, et al, 2016).…”