Clinical Outcomes of Stereotactic Ablative Radiation Therapy in Pulmonary Metastasis

Abstract

regulated in HF group, and in RT+HF group and RT+SB group its expression down-regulated than RT group. Scratch Assay and Transwell Chamber Assay results show that compared to RT group, the areas of scratch wound healing were reduced and the numbers of the cells transferred to the lower surface in transwell chamber were decreased in RT+HF group and RT+SB group. Immunohistochemistry results show that in RT+HF group and RT+SB group, compared to that in the RT group, the expressions of epithelial markers E-Cadherin was enhanced and mesenchymal markers N-Cadherin was descended. RT+HF group and RT+SB group had lower level of TGF-b expression than the RT group. Conclusion: Halofuginone could inhibit the epithelial-mesenchymal transition of lung cancer cells and xenograft induced by irradiation. The possible mechanism may be due to the inhibition effect on TGF-b signal transduction.