Clinical Outcomes of Thermal Ablation Re-Treatment of Benign Thyroid Nodules: A Multicenter Study from the Italian Minimally Invasive Treatments of the Thyroid Group

Bernardi, Stella; Rosolen, Valentina; Barbone, Fabio; Borgato, Stefano; Deandrea, Maurilio; De Feo, Pierpaolo; Fugazzola, Laura; Gambelunghe, Giovanni; Negro, Roberto; Oleandri, Salvatore; Papi, Giampaolo; Papini, Enrico; Retta, Francesca; Rossetto, Ruth; Sansone, Daniela; Serra, Giuseppe; Sconfienza, Luca Maria; Solbiati, Luigi; Spiezia, Stefano; Stacul, Fulvio; Mauri, Giovanni

doi:10.1089/thy.2023.0501

Thyroid®

2024

DOI: 10.1089/thy.2023.0501

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Clinical Outcomes of Thermal Ablation Re-Treatment of Benign Thyroid Nodules: A Multicenter Study from the Italian Minimally Invasive Treatments of the Thyroid Group

Stella Bernardi,

Valentina Rosolen,

Fabio Barbone

et al.

Abstract: ThyroidClinical outcomes of thermal ablation retreatment of benign thyroid nodules: A multicenter study from the Italian minimally-invasive treatments of the thyroid group

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2024

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Cited by 4 publications

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“…Potential and non-modifiable factors such as nodule vascularization, composition, anatomical site and biological characteristics as well as patients' compliance likely play a key role in the final volume reduction independently from the increased skill of the operator. Consistent with this, Bernardi et al, investigated the outcomes of re-treatment on symptomatic BTN with a VRR <50% after the initial thermal ablation treatment (19). The RFA re-treatment led to greater VRR as compared to the first treatment only in small and medium nodules (<30 mL) but not in large nodules (>30 mL).…”

mentioning

confidence: 91%

Proficiency in performing radiofrequency ablation procedure for non-functioning benign thyroid nodules: a qualitative rather than quantitative matter

Chytiris,

Teliti,

Croce

et al. 2024

Front. Endocrinol.

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ObjectiveRadiofrequency ablation (RFA) is an emerging non-surgical treatment for benign thyroid nodules (BTN). Despite its proven safety profile, data on the learning curve (LC) required to achieve proficiency are still lacking.Materials and methodsThe first 179 RFA procedures performed by a single operator in patients with non-functioning BTN were retrospectively analyzed. Six-month nodule volume reduction rate (VRR) ≥ 50% was regarded as reflection of proficiency. Multiple linear regression analysis has been performed to determine the relationship between the VRR and clinical variables. Cumulative sum (CUSUM) charts were plotted to assess LCs for all consecutive procedures and in relation to basal nodule size. In details, Group 1 (G1): 57 patients with small nodules (<10 ml); Group 2 (G2): 87 patients with intermediate nodules (10 – 25 ml); Group 3 (G3): 35 patients with large size (> 25 ml).ResultsLC of all 179 procedures showed 3 phases: initial learning (1–39 procedures); consolidation (40–145 procedures); and experienced period (146–179 procedures). For G1 and G2 proficiency is achieved starting from the 10th procedure within the group (or 37th considering consecutively all procedures) and from the 59th procedure within the group (or 116th considering consecutively all procedures), respectively. LC of G3 did not detect operator proficiency.ConclusionSpecific LCs exist concerning the basal size of the nodule treated with RFA. In nodules with baseline volume > 25 ml suboptimal VRR has to be expected. Previously achieved experience on small-intermediate nodules does not seem to provide advantages in terms of higher VRR in the treatment of large nodules. Other potential and non-modifiable factors likely play a key role in the final volume reduction independently from the increased skill of the operator.

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mentioning

confidence: 91%

Proficiency in performing radiofrequency ablation procedure for non-functioning benign thyroid nodules: a qualitative rather than quantitative matter

Chytiris,

Teliti,

Croce

et al. 2024

Front. Endocrinol.

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Benign Thyroid Nodule Interventions: A Review and Imaging Considerations for the Interventional Radiologist

Park,

Huber,

Marchak

et al. 2024

Semin intervent Radiol

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Thyroid radiofrequency ablation (RFA) is a minimally invasive procedure that can be used to treat patients with benign thyroid nodules and is a good alternative to thyroidectomy or radioactive iodine. Thyroid RFA is commonly performed with local lidocaine or minimal/moderate sedation and has a minimal risk profile and few side effects. The efficacy of thyroid RFA has been well documented in the literature, with a volume reduction rate of 67 to 75% at 1 year. Another emerging technique for nodule size reduction is thyroid artery embolization which is a minimally invasive procedure that may be performed in patients with nodular goiters, particularly with substernal thyroid nodule extension, and who are either poor surgical candidates or do not want surgery. This article reviews thyroid RFA, focusing on the relevant preprocedural, procedural, and postprocedural imaging, as well as a discussion on the emerging role of thyroid artery embolization.

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Benign Thyroid Nodules Respond Better to Thermal Ablation Retreatment If They Are Smaller

Hussain

2024

Clinical Thyroidology®

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Clinical Outcomes of Thermal Ablation Re-Treatment of Benign Thyroid Nodules: A Multicenter Study from the Italian Minimally Invasive Treatments of the Thyroid Group

Abstract: ThyroidClinical outcomes of thermal ablation retreatment of benign thyroid nodules: A multicenter study from the Italian minimally-invasive treatments of the thyroid group

Cited by 4 publications

References 34 publications

Proficiency in performing radiofrequency ablation procedure for non-functioning benign thyroid nodules: a qualitative rather than quantitative matter

Proficiency in performing radiofrequency ablation procedure for non-functioning benign thyroid nodules: a qualitative rather than quantitative matter

Benign Thyroid Nodule Interventions: A Review and Imaging Considerations for the Interventional Radiologist

Benign Thyroid Nodules Respond Better to Thermal Ablation Retreatment If They Are Smaller

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