Clinical outcomes of transepithelial photorefractive keratectomy with epithelial ablation targeting actual epithelial thickness vs default laser platform values

Hashemian, Morteza; Faegh, Adeleh; Latifi, Golshan; Abdi, Parisa

doi:10.1097/j.jcrs.0000000000000803

Cited by 3 publications

(3 citation statements)

References 29 publications

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“…Using VHFU technology, Reinstein et al showed that the average central CET was 53.4 ± 4.6 μm, comparable with SD-OCT [22]. Using SD-OCT, normal CET profles were described to be thicker in the central 2 mm of the cornea ranging from 53 to 54 μm in the center and decreased with a low gradient of −0.43 μm/mm toward 7 mm midperiphery and a larger gradient of −2.31 μm/mm toward 9 mm periphery [45,52,60,[71][72][73]; VHF-US studies did not fnd such thinning trends [22].…”

Section: Corneal Epithelium In Normal Eyesmentioning

confidence: 69%

“…In a contralateral eye study, our team compared the effect of programming the laser device with the actual CET profile in the center and periphery for T-PRK in virgin right eyes compared to the default protocol of the device, which considered CET 55 μ m in the center and 65 μ m in the periphery in the left eye. We did not find a significant difference in wasted tissue, but slightly hyperopic results and more contracted optical zones were noted [ 72 ].…”

Section: Refractive Surgerymentioning

confidence: 96%

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Corneal Epithelial Thickness Mapping: A Major Review

Abtahi,

Beheshtnejad,

Latifi

et al. 2024

Journal of Ophthalmology

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The corneal epithelium (CE) is the outermost layer of the cornea with constant turnover, relative stability, remarkable plasticity, and compensatory properties to mask alterations in the underlying stroma. The advent of quantitative imaging modalities capable of producing epithelial thickness mapping (ETM) has made it possible to characterize better the different patterns of epithelial remodeling. In this comprehensive synthesis, we reviewed all available data on ETM with different methods, including very high-frequency ultrasound (VHF-US) and spectral-domain optical coherence tomography (SD-OCT) in normal individuals, corneal or systemic diseases, and corneal surgical scenarios. We excluded OCT studies that manually measured the corneal epithelial thickness (CET) (e.g., by digital calipers) or the CE (e.g., by confocal scanning or handheld pachymeters). A comparison of different CET measuring technologies and devices capable of producing thickness maps is provided. Normative data on CET and the possible effects of gender, aging, diurnal changes, refraction, and intraocular pressure are discussed. We also reviewed ETM data in several corneal disorders, including keratoconus, corneal dystrophies, recurrent epithelial erosion, herpes keratitis, keratoplasty, bullous keratopathy, carcinoma in situ, pterygium, and limbal stem cell deficiency. The available data on the potential role of ETM in indicating refractive surgeries, planning the procedure, and assessing postoperative changes are reviewed. Alterations in ETM in systemic and ocular conditions such as eyelid abnormalities and dry eye disease and the effects of contact lenses, topical medications, and cataract surgery on the ETM profile are discussed.

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Section: Corneal Epithelium In Normal Eyesmentioning

confidence: 69%

Section: Refractive Surgerymentioning

confidence: 96%

Corneal Epithelial Thickness Mapping: A Major Review

Abtahi,

Beheshtnejad,

Latifi

et al. 2024

Journal of Ophthalmology

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“…The real value of Table 2 is that the analysis of postoperative results is based on a huge amount of data. To our knowledge, no analysis of such a large amount of data has previously been published in the literature [13][14][15][16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

A comparison of the results of old-generation (MEL 60) and new-generation (SCHWIND AMARIS) refractive excimer laser treatments

Dió,

Molnár,

Szekrényesi

et al. 2024

DHS

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PurposeThe present study compares the efficacy of refractive surgery using third-generation and sixth-generation laser vision correction procedures in terms of postoperative visual acuity. The goal of the authors was to determine whether advances in laser technology had improved patients' uncorrected visual acuity, as measured at six-month follow-ups.Materials/MethodsResults were reported from one of Europe's leading laser eye clinics, which has performed an outstandingly high number of treatments (over 100,000). The results of the clinic's first 10,000 treatments and most recent 10,000 treatments were evaluated.ResultsThe analysis was performed by treated dioptric range and age group. The raw six-month visual acuity results show a statistically significant improvement over the last 10,000 interventions. The treatments resulted in significant improvements in all groups compared to the previous technology. With the new devices, visual acuity increased to above 1.0 in young myopes. The best results were seen in patients between 18 and 45 years of age, in the dioptric range between −1.0 D and −6.0 D.ConclusionsIt can be concluded that advances in technology improved refractive outcomes in all patient groups. This conclusion has excellent reliability and predictability due to the particularly high number of cases.

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Blepharoptosis and corneal epithelial thickness alterations, is there any relation?

Rafizadeh,

Sonbolestan,

Zeidabadinejad

et al. 2024

BMC Ophthalmol

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Background To compare the epithelial thickness map of ptotic eyes of blepharoptosis patients with contralateral non- ptotic eyes. Methods Unilateral blepharoptosis patients were enrolled consecutively. Patients were underwent full ophthalmologic examination and their demographic data such as age and gender and specific ptosis findings e.g. the cause and duration, MRD-1, and levator palpebralis superioris function were registered. Anterior segment imaging for epithelial thickness measurements was done using the Avanti RTVue-XR platform. The corneal epithelial thickness maps of ptotic and non-ptotic eyes were compared. Results 44 patients with unilateral blepharoptosis were included in the study. 27 (61.4%) of them were female and 17 (38.6%) cases were male. The mean of the patients’ ages was 24.40 ± 15.16 years. Ptotic eyes had significantly thinner superior (p = 0.000), superior-temporal (p = 0.000) and superior-nasal (p = 0.005) sectors of the cornea and slightly thicker corneal epithelium (CE) in the inferior-nasal sector. The correlation of difference of superior-inferior CE was evaluated with different parameters including patient’s age (p = 0.457), type of blepharoptosis (p = 0.786), duration of blepharoptosis (p = 0.477) and MRD1 (p = 0.248), but no correlation was found. Conclusions This study revealed that lid position in blepharoptosis may have effects on the corneal epithelial thickness map. Because of the lower position of upper eyelid, a thinning effect on superior corneal sectors may happen.

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Clinical outcomes of transepithelial photorefractive keratectomy with epithelial ablation targeting actual epithelial thickness vs default laser platform values

Abstract: In transepithelial PRK, refractive outcome depends little on preexisting corneal epithelial thickness. There is a concern about the contraction of OZ, especially in lower intended ablations.

Cited by 3 publications

References 29 publications

Corneal Epithelial Thickness Mapping: A Major Review

Corneal Epithelial Thickness Mapping: A Major Review

A comparison of the results of old-generation (MEL 60) and new-generation (SCHWIND AMARIS) refractive excimer laser treatments

Blepharoptosis and corneal epithelial thickness alterations, is there any relation?

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