Clinical outcomes of two different endometrial preparation methods for cryopreserved‐thawed embryo transfer in patients with a normal menstrual cycle

Kawamura, Toshihiro; Motoyama, Hiroshi; Yanaihara, Atsushi; Yorimitsu, Takeshi; Arichi, Akane; Karasawa, Yasuhiro; Suga, Kahori; Miya, Kaoru; Ishikawa, Seika; Mizushima, Shiho; Kawamura, Makiko

doi:10.1111/j.1447-0578.2007.00165.x

Cited by 31 publications

(23 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gardner's classification was used for embryo scoring before transfer [9]. A single blastocyst was transferred on day 5 of a natural cycle or day 6 of a hormone replacement cycle [10,11]. For endometrial preparation, Estrana® (Hisamitsu Pharmaceutical Co. Inc., Saga, Japan) was begun on the third menstrual day and continued until endometrial thickness was >8 mm.…”

Section: Methodsmentioning

confidence: 99%

Clinical outcome of frozen blastocyst transfer; single vs. double transfer

Yanaihara¹,

Yorimitsu²,

Motoyama³

et al. 2008

J Assist Reprod Genet

Self Cite

View full text Add to dashboard Cite

Purpose Frozen embryo transfer has been established as an indispensable ART procedure for both the effective use of surplus embryos and the prevention of ovarian hyperstimulation syndrome. The frequency of frozen embryo transfer is increasing in our clinic, and we report that frozen embryo transfer is effective for patients with repeat failures. We present our clinical outcome of frozen blastocyst transfer (FBT). Methods In 2006, 470 patients received FBT (562 cycles (IVF: 354 cycles; ICSI: 208 cycles)). One frozen blastocyst was transferred in 412 cycles (335 patients) and two blastocysts were transferred in 150 cycles (135 patients). Assisted hatching was performed in all cases. Results In 412 cycles (average age: 34.6 years) who received a single FBT, the rate of clinical pregnancy per cycle was 40.7%, the live birth rate was 29.1%, the abortion rate was 21.6%, the ectopic pregnancy rate was 1.2%, the frequency of monochorionic twins was 2.3%, and the cesarean section rate was 38.3%. In 150 cycles (average patient age 34.8 years) who received two FBTs, the clinical pregnancy rate was 46%, the live birth rate was 35.3%, the abortion rate was 16.3%, the ectopic pregnancy rate was 4.4%, the frequency of twins was 15.9% and the cesarean section rate was 39.6%. A significant difference in the ectopic pregnancy rate and the twinning rate was found between single transfers and double transfers (P<0.05). When IVF and ICSI were compared, there was no statistically significant difference in the abortion rate, the ectopic pregnancy rate, and the cesarean section rate. Conclusions The clinical pregnancy rate was similar for the transfer of one and two blastocysts. Single FBT decreases obstetrical risk without reducing the pregnancy rate.

show abstract

Section: Methodsmentioning

confidence: 99%

Clinical outcome of frozen blastocyst transfer; single vs. double transfer

Yanaihara¹,

Yorimitsu²,

Motoyama³

et al. 2008

J Assist Reprod Genet

Self Cite

View full text Add to dashboard Cite

show abstract

“…4). A total of six studies, one RCT [50] and five retrospective cohort studies [32,35,36,51,52] making a total of 6074 ET cycles, were included.…”

Section: Tnc Versus Ac With Suppressionmentioning

confidence: 99%

“…Without LPS, there was no significant difference for clinical pregnancy (OR 1.08, 95 % CI 0.88-1.33; two studies) or live birth rates (OR 1.23 95 % CI 0.98-1.55; two studies). In four studies, LPS was administered in the mNC arm [32,35,51,52] With LPS, the ORs for clinical pregnancy and live …”

Section: Tnc Versus Ac With Suppressionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Yaralı́

Polat

Mümüşoğlu

et al. 2016

J Assist Reprod Genet

109

View full text Add to dashboard Cite

Purpose The purpose of this study was to evaluate the best protocol to prepare endometrium for frozen embryo replacement (FER) cycles. Methods This study is a systematic review and meta-analysis. Following PubMed and OvidSP search, a total of 1166 studies published after 1990 were identified following removal of duplicates. Following exclusion of studies not matching our inclusion criteria, a total of 33 studies were analyzed. Primary outcome measure was live birth. The following protocols, including true natural cycle (tNC), modified natural cycle (mNC), artificial cycle (AC) with or without suppression, and mild ovarian stimulation (OS) with gonadotropin (Gn) or aromatase inhibitor (AI), were compared. Results No statistically significant difference for both clinical pregnancy and live birth was noted between tNC and mNC groups. When tNC and AC without suppression groups are compared, there was a statistically significant difference in clinical pregnancy rate in favor of tNC, whereas it failed to reach statistical significance for live birth. When tNC and AC with suppression groups are compared, there was a statistically significant difference in live birth rate favoring the latter. Similar pregnancy outcome was noted among mNC versus AC with or without suppression groups. Similarly, no difference in clinical pregnancy and live birth was noted when ACs with or without suppression groups are compared. Conclusions There is no consistent superiority of any endometrial preparation for FER. However, mNC has several advantages (being patient-friendly; yielding at least equivalent or better pregnancy rates when compared with tNC and AC with or without suppression; may not require LPS). Mild OS with Gn or AI may be promising.

show abstract

“…The freezing of all the embryos in those at high risk of moderate to severe ovarian hyperstimulation syndrome (OHSS) is an essential strategy to avoid this complication. Furthermore, the cryopreservation of embryos after fresh embryo transfer (ET) provides the possibility of further embryo transfers to increase cumulative pregnancy rates per oocyte pick-up (OPU) cycle in a cost-effective way [Kawamura et al 2007;Alama et al 2007;Ghobara et al 2008]. …”

Section: Introductionmentioning

confidence: 99%

Natural cycle is superior to hormone replacement therapy cycle for vitrificated-preserved frozen-thawed embryo transfer

Xiao

Zhou

et al. 2011

Systems Biology in Reproductive Medicine

View full text Add to dashboard Cite

We undertook this retrospective variables-control analysis to compare the reproductive outcomes of frozen-thawed embryo transfer using endometrial preparation with either natural cycle or hormone replacement therapy cycle. Patients were divided into three subgroups. Subgroup A (n = 32) consisted of patients having three 8-cell post-thawed embryos transferred. Subgroup B (n = 404) consisted of patients having three good quality post-thawed embryos transferred. Subgroup C (n = 578) consisted of patients having two or three all intact and mitosis resumption post-thawed embryos transferred. Implantation rate, biochemical pregnancy rate, and clinical pregnancy rate were measured. In subgroup A, significantly higher implantation rate, clinical pregnancy rate ongoing pregnancy rate, and lower biochemical pregnancy rate were observed in the natural cycle compared with hormone replacement therapy (HRT) cycle. Subgroup B, had a significantly higher rate of implantation, ongoing pregnancy, and a significantly lower rate of biochemical pregnancy in natural cycle compared with HRT cycle. The natural cycle had a higher trend of clinical pregnancy rate without reaching statistical significance. No statistical difference in reproductive outcomes between natural cycle and HRT cycle was observed in subgroup C. The results suggest the superiority of the natural cycle as compared with the HRT cycle under certain circumstances in a selected population of patients.

show abstract

Clinical outcomes of two different endometrial preparation methods for cryopreserved‐thawed embryo transfer in patients with a normal menstrual cycle

Cited by 31 publications

References 13 publications

Clinical outcome of frozen blastocyst transfer; single vs. double transfer

Clinical outcome of frozen blastocyst transfer; single vs. double transfer

Preparation of endometrium for frozen embryo replacement cycles: a systematic review and meta-analysis

Natural cycle is superior to hormone replacement therapy cycle for vitrificated-preserved frozen-thawed embryo transfer

Contact Info

Product

Resources

About