Clinical Outline of Oral Diseases

Santosh, Arvind Babu Rajendra; Boyd, D.; Laxminarayana, Kumaraswamy Kikeri

doi:10.1016/j.cden.2019.08.001

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…DC is a chronic disease that is usually affected by environmental and host agents and even genetic factors [2,[46][47][48][49]. Therefore, early detection, early diagnosis, and early treatment are the main considerations for the prevention and treatment of DC [50,51].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Beta-Defensin 1 and Mannose-Binding Lectin 2 Polymorphisms in Children with Dental Caries Compared to Caries-Free Controls: A Systematic Review and Meta-Analysis

et al. 2023

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Background and objective: Some variants in defensin beta 1 (DEFB1) and mannose-binding lectin 2 (MBL2) genes can be associated with oral diseases. Herein, we designed a systematic review and meta-analysis to evaluate the association of DEFB1 (rs11362, rs1799946, and rs1800972) and MBL2 (rs7096206 and rs1800450) polymorphisms with the susceptibility to dental caries (DC) in children. Materials and methods: A systematic literature search was conducted in the PubMed/Medline, Web of Science, Scopus, and Cochrane Library databases until 3 December 2022, without any restrictions. The odds ratio (OR), along with a 95% confidence interval (CI) of the effect sizes, are reported. Analyses including a subgroup analysis, a sensitivity analysis, and funnel plot analyses were conducted. Results: A total of 416 records were identified among the databases, and nine articles were entered into the meta-analysis. A significant relationship was found between the T allele of DEFB1 rs11362 polymorphism and DC susceptibility, and the T allele was related to an elevated risk of DC in children (OR = 1.225; 95%CI: 1.022, 1.469; p = 0.028; I2 = 0%). No other polymorphisms were associated with DC. All articles were of moderate quality. Egger’s test in homozygous and dominant models demonstrated a significant publication bias for the association of DEFB1 rs1799946 polymorphism with DC risk. Conclusions: The results demonstrated that the T allele of DEFB1 rs11362 polymorphism had an elevated risk for DC in children. However, there were only few studies that evaluated this association.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Beta-Defensin 1 and Mannose-Binding Lectin 2 Polymorphisms in Children with Dental Caries Compared to Caries-Free Controls: A Systematic Review and Meta-Analysis

et al. 2023

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“…Dental caries is a chronic disease that is mainly caused by environmental and host factors; thus, early detection, early diagnosis, and early treatment are important considerations for prevention and treatment of dental caries. 6 , 16 In the present study, all participating children were permanent residents of a relatively small region of China, which minimized sample heterogeneity. Our epidemiological investigation showed that these children had similar socioeconomic backgrounds, diets, water fluoride concentrations, and oral hygiene statuses (some data not shown).…”

Section: Discussionmentioning

confidence: 99%

Lack of associations between lactoferrin (LTF) and mannose-binding lectin 2 (MBL2) gene polymorphism and dental caries susceptibility

Hu¹,

Zhou²,

et al. 2020

J Int Med Res

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Objective With the development of human genomics, the genetic factors associated with dental caries have receiving increasing attention. This study was performed to evaluate the relationship between lactoferrin ( LTF) and mannose-binding lectin 2 ( MBL2) gene single nucleotide polymorphisms (SNPs) and dental caries susceptibility in Chinese children. Methods This prospective case–control study included 360 unrelated children (aged 12–15 years) who received oral health examinations and questionnaire surveys. The children were divided into two groups by counting the numbers of decayed, missing, and filled teeth (DMFT/dmft): case group (n = 162, DMFT/dmft ≥ 1) and control group (n = 198, DMFT/dmft = 0); non-invasive saliva samples were collected to extract genomic DNA. Six SNPs ( rs2073495C/G, rs1042073C/T, rs10865941C/T, and rs1126477A/G in LTF; rs7096206C/G and rs7095891G/A in MBL2) were tested by mass spectrometry. Results The study included 360 individuals with (85 boys and 77 girls) and without a history of caries (96 boys and 102 girls). There were no statistically significant differences in alleles and genotypes among the six SNPs between the two groups. Conclusion There is no evidence that polymorphisms of LTF and MBL2 genes are associated with dental caries susceptibility in populations from northwest China; further confirmation is needed with larger sample sizes.

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“…Los quistes óseos de la región maxilofacial corresponden a una patología benigna, principalmente de etiología odontogénica. Estos corresponden a una cavidad ósea recubierta de epitelio odontogénico de contenido líquido, semifluido o gaseoso rodeado por una capsula (Rajendra Santosh et al, 2020). Los quistes más frecuentes son el quiste radicular, el quiste dentígero, y el queratoquiste odontogénico, que en conjunto son más del 80 % de los quistes maxilares (Johnson et al, 2014).…”

Section: Introductionunclassified

Injertos Óseos en Quistes de los Maxilares. Reporte de un Caso

Cofré-Leiva,

Figueroa-Colarte,

López-Nilo

et al. 2024

Int. J. Odontostomat.

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RESUMEN: Los quistes de los maxilares son las lesiones óseas más comunes en la región maxilofacial. La enucleación de las lesiones y el cierre primario de los defectos, son en conjunto, el tratamiento óptimo hoy en día. En algunas ocasiones el defecto óseo resultante puede ser de un tamaño tan grande que afecta la estabilidad de dientes vecinos, comprometa la indemnidad del hueso o produce un retraso cicatrizal que incluso puede impedir una regeneración ósea completa. Se considera que esta falta de regeneración expone al paciente a riesgos de infección tardía, retraso de los tratamientos rehabilitadores en zonas de alta demanda estética y pérdida de vitalidad dentaria. Para disminuir el riesgo de alteraciones en la regeneración ósea completa de cavidades quísticas, se ha propuesto la posibilidad de que tras la enucleación del quiste se rellenen estos defectos con injertos óseos u otras técnicas de preservación alveolar para favorecer la cicatrización. Teóricamente el uso de estos injertos mejora la calidad y disminuye el tiempo de cicatrización ósea, permitiendo que el paciente recupere rápidamente las funciones habituales del componente dentoalveolar, acortando el periodo de cuidados postoperatorios que restringen la alimentación, los deportes o la rehabilitación oral. El actual trabajo tiene como objetivo realizar una revisión de la literatura respecto a los beneficios del uso de injertos óseos en el tratamiento quirúrgico de los quistes maxilares y presentar un caso clínico con los detalles quirúrgicos de esta técnica.PALABRAS CLAVE: quistes maxilares, enucleación, injerto óseo, regeneración ósea.

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Clinical Outline of Oral Diseases

Cited by 9 publications

References 24 publications

Evaluation of Beta-Defensin 1 and Mannose-Binding Lectin 2 Polymorphisms in Children with Dental Caries Compared to Caries-Free Controls: A Systematic Review and Meta-Analysis

Evaluation of Beta-Defensin 1 and Mannose-Binding Lectin 2 Polymorphisms in Children with Dental Caries Compared to Caries-Free Controls: A Systematic Review and Meta-Analysis

Lack of associations between lactoferrin (LTF) and mannose-binding lectin 2 (MBL2) gene polymorphism and dental caries susceptibility

Injertos Óseos en Quistes de los Maxilares. Reporte de un Caso

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