Clinical overlap between fibromyalgia and myalgic encephalomyelitis. A systematic review and meta-analysis

Ramírez-Morales, Ricardo; Bermúdez-Benítez, Elyzabeth; Martínez-Martínez, Laura-Aline; Martı́nez-Lavı́n, Manuel

doi:10.1016/j.autrev.2022.103129

Cited by 19 publications

(12 citation statements)

References 36 publications

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“…[5] Although the overlap has been discussed for a long time, a recent systematic review indicates that almost half of the reported cases overlapped FM and ME/ CFS. [6] Presently, FM does not have radical treatments. However, various treatments are suggested for relieving symptoms.…”

Section: Introductionmentioning

confidence: 98%

Severe fibromyalgia alleviated by the unique muscle relaxation method of applying low force: A case report

Amitani,

Nishi,

Fukumoto

et al. 2024

Medicine

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Rationale: Fibromyalgia (FM) is characterized by idiopathic persistent chronic pain in the ligaments or musculoskeletal system, and more than half of the patients with FM might have migraine headaches. Direct musculoskeletal intervention could be a non-pharmacological management to relieve symptoms. However, patients with severe FM often have intense pain from only a soft touch, thereby rendering musculoskeletal intervention challenging. Patient concerns: A 47-year-old man had progressing intense pain, and this affected his everyday life. There were no abnormal physical findings on laboratory examination such as levels of complement, antinuclear antibodies, and C-reactive protein, which were within normal limits. Magnetic resonance imaging did not indicate abnormalities. Diagnoses, interventions, and outcomes: The patient satisfied the American College of Rheumatology criteria. Finally, we made a final diagnosis of fibromyalgia. The therapeutic intervention of Kanshoho, the unique muscle relaxation technique with low force, relieved his pain. Lessons: If Kanshoho is carefully applied in a state of hospitalization under surveillance by an experienced physician, it could be a promising muscle relaxation method. Relaxing the trapezius muscle and reducing its intramuscular pressure might be key in treating patients with severe FM. However, it needs elucidation of its mechanism.

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Section: Introductionmentioning

confidence: 98%

Severe fibromyalgia alleviated by the unique muscle relaxation method of applying low force: A case report

Amitani,

Nishi,

Fukumoto

et al. 2024

Medicine

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“…While in one study 34% of 313 patients diagnosed with ME/CFS had comorbid FM according to the American College of Rheumatology (ACR) old diagnostic criteria of 1990, the other research group reported that the prevalence of FM among patients with ME/CFS could reach 50% when ACR 2010 newer diagnostic criteria were applied [4]. The recent meta-analysis confirmed a prominent clinical overlap between FM and ME/CFS [5]. Although the exact pathogenesis of ME/CFS is still unknown, according to the most widely held hypothesis, it is a complex multifactorial syndrome with immunological, metabolic, mitochondrial, autonomic and adrenal dysfunction as the key pathogenetic mechanisms [6,7].…”

Section: Introductionmentioning

confidence: 99%

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity

Ryabkova

Gavrilova

Poletaeva³

et al. 2023

Biomedicines

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Recent studies provide some evidence for the contribution of antibody-mediated autoimmune mechanisms to the nature of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Much attention was paid to the autoantibodies (AAb) targeting G protein-coupled receptors as natural components of the immune system. However, the natural AAb network is much more extensive, and has not been previously investigated in these disorders. The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to determine changes in serum content of 33 natural AAb to neural, organ-specific and non-tissue-specific autoantigens (a) in 11 ME/CFS patients with comorbid FM; (b) in 11 ME/CFS patients without FM; (c) in 11 healthy controls. Individual AAb profiles and their correlation with some clinical symptoms were analyzed. Both patients with ME/CFS(−)FM and ME/CFS(+)FM were characterized by more frequent and pronounced deviations in the immunoreactivity to GABA-receptors than healthy controls. Although the level of other natural AAb did not differ between study groups, AAb correlation signatures were altered in patients compared to healthy controls. Both in patients and healthy controls the level of natural AAb to various neural and tissue-specific antigens correlated with the severity of fatigue, bodily pain, depression, anxiety, physical and mental health-related quality of life. Notably, widely different correlation patterns were observed between study groups. Findings from this pilot study provide some evidence that the homeostasis of autoimmune relationships, which are possibly a physiological part of our immune system, may be altered in FM and ME/CFS. The correlation of disease-induced perturbations in individual AAb profiles with some clinical symptoms may arise from the immune system’s ability to reflect qualitative and quantitative changes in antigenic composition of the body.

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“…[6] FM thus represents a high cost for society, estimated at €12.9 million in Spain in 2017. [7] CFS, which often overlaps with FM, [8,9] affects all ages and socioeconomic groups, although it is most common in the 30 to 50 age group. The estimated prevalence in the United States is 0.42%, of which 70% are women.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness and health benefits of a nutritional, chronobiological and physical exercise primary care intervention in fibromyalgia and chronic fatigue syndrome: SYNCHRONIZE + mixed-methods study protocol

Carrasco-Querol¹,

Serra²,

Hernández³

et al. 2023

Medicine

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Introduction: Chronic pain, fatigue and insomnia are classic symptoms of fibromyalgia (FM) and chronic fatigue syndrome (CFS) and seriously affect quality of life. Nutrition and chronobiology are often overlooked in multicomponent approach despite their potential. This study aims to evaluate the effectiveness of a multidisciplinary group intervention based on nutrition, chronobiology, and physical exercise in the improvement of lifestyle and quality of life in FM and CFS. Methods: Mixed-methods study based on a randomized clinical trial and qualitative analysis with a descriptive phenomenological approach. The study will be conducted in primary care in Catalonia. The control group will follow the usual clinical practice and the intervention group the usual practice plus the studied intervention (12 hours over 4 days). The intervention based on nutrition, chronobiology and physical exercise will be designed considering participants’ opinions as collected in 4 focus groups. To evaluate effectiveness, EuroQol-5D, multidimensional fatigue inventory, VAS pain, Pittsburgh Sleep Quality Index, erMEDAS-17, biological rhythms interview of assessment in neuropsychiatry, REGICOR-Short, FIQR and Hospital Anxiety and Depression Scale questionnaires will be collected at baseline, and at 1, 3, 6, and 12 months post-intervention. Food intake, body composition, resistance and, strength will also be evaluated. The effect size will be calculated using Cohen d and logistic regression models will be used to quantify the impact of the intervention by adjusting for different variables. Discussion: It expected that the intervention will improve the patients’ quality of life, fatigue, pain and insomnia, as well as food and physical exercise habits, providing effectiveness evidence of a new therapy in addressing these syndromes in Primary Heath Care. Improvements in the quality of life will have a positive socioeconomic impact by reducing health expenditure on recurrent medical consultation, medication, complementary medical tests, etc and favor the maintenance of an active working life and productivity.

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Clinical overlap between fibromyalgia and myalgic encephalomyelitis. A systematic review and meta-analysis

Cited by 19 publications

References 36 publications

Severe fibromyalgia alleviated by the unique muscle relaxation method of applying low force: A case report

Severe fibromyalgia alleviated by the unique muscle relaxation method of applying low force: A case report

Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity

Effectiveness and health benefits of a nutritional, chronobiological and physical exercise primary care intervention in fibromyalgia and chronic fatigue syndrome: SYNCHRONIZE + mixed-methods study protocol

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