Clinical Panel Assessment of Photodamaged Skin Treated With Isotretinoin Using Photographs

Armstrong, R. B.

doi:10.1001/archderm.1992.01680130066007

Cited by 21 publications

(5 citation statements)

References 5 publications

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“…It was confirmed that the application of 0.05% isotretinoin in combination with sunscreens improved the appearance of the fine wrinkles associated with photoaged skin [ 66 ]. The results were consistent with previously performed studies by other authors [ 64 , 65 ]. It can be concluded that most of the performed studies about topical application of isotretinoin for photodamaged skin showed statistically significant improvement in the overall appearance of the skin including fine lines and pigmentation.…”

Section: Clinical Evidencesupporting

confidence: 94%

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

Milosheska¹,

Roškar

2022

Adv Ther

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Nowadays, numerous skincare routines are used to rejuvenate aging skin. Retinoids are one of the most popular ingredients used in antiaging treatments. Among the representatives of retinoids, tretinoin is considered the most effective agent with proven antiaging effects on the skin and can be found in formulations approved as medicines for topical treatment of acne, facial wrinkles, and hyperpigmentation. Other retinoids present in topical medicines are used for various indications, but only tazarotene is also approved as adjunctive agent for treatment of facial fine wrinkling and pigmentation. The most commonly used retinoids such as retinol, retinaldehyde, and retinyl palmitate are contained in cosmeceuticals regulated as cosmetics. Since clinical efficacy studies are not required for marketing cosmetic formulations, there are concerns about the efficacy of these retinoids.

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Section: Clinical Evidencesupporting

confidence: 94%

Use of Retinoids in Topical Antiaging Treatments: A Focused Review of Clinical Evidence for Conventional and Nanoformulations

Milosheska¹,

Roškar

2022

Adv Ther

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“…Isotretinoin appears to be less irritating and perhaps less effective than tretinoin but this may be because it requires isomerization to tretinoin for activity. Two other studies 28,29 have reported improvement in fine wrinkles after 36 weeks of treatment comprising an initial 12‐week course of isotretinoin 0.05% cream followed by 24 weeks of a 0.1% formulation. The effectiveness of retinaldehyde (retinal) 0.05% cream for treatment of photoageing has been compared directly with 0.05% tretinoin and vehicle creams over an 18‐week period 30 .…”

Section: Topical Retinoids In the Management Of Photoageingmentioning

confidence: 97%

The role of retinoids in the prevention and repair of aged and photoaged skin

Griffiths

2001

Clinical and Experimental Dermatology

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Retinoids, either naturally occurring or synthetic, are defined by their ability to bind nuclear retinoid receptors of the steroid/thyroid superfamily. Their protean but key function in physiology is control of cellular proliferation and differentiation. Topical retinoids, namely tretinoin, have been proven to prevent and repair clinical features of photoageing; these processes are facilitated by an ability to prevent loss of collagen from, and stimulate new collagen formation in, the papillary dermis of sun-exposed skin. Emerging evidence indicates that intrinsic, chronological ageing of the skin shares several mechanistic features with photoageing. Indeed aged skin is characterized by retinoid sensitivity and is probably reparable by application of topical retinoids.

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“…Armstrong et al ., 54 in a well‐conducted trial, reported significantly better improvement of photodamaged skin treated with 0.5–1.0% isotretinoin cream. Later, Sendagorta et al 55 .…”

Section: Photodamaged Skinmentioning

confidence: 98%