Clinical, parasitological and molecular profiles of Cutaneous Leishmaniasis and its associated factors among clinically suspected patients attending Borumeda Hospital, North-East Ethiopia

Abstract

Background Cutaneous leishmaniasis is one of the most neglected tropical diseases increasing in its public health importance. In Ethiopia over 28 million people are living at risk of infection. Method Institution based cross-sectional study was conducted at Borumeda Hospital from February to May 2019. A total 205 leishmaniasis suspected patients were included by systematic random sampling technique. Socio demographic characteristics were collected using pretested questionnaires. Parasitological investigation was done from skin slit sample by using Geimsa staining method. Species identification was done by PCR-RFLP. Data were entered in to EpiData version 3.1 and analyzed using SPSS version 20 software. P-value of � 0.05 was considered as statistically significant. Result A total of 205 participants consisting 59% male and 41% female included in this study. The mean age (±SD) of the study participants was 31.9 (±14.29). The overall prevalence of cutaneous leishmaniasis was 22.4% (46/205). The prevalence in males (13.7%) was higher than in females (8.8%). It was more prevalent in the age group 16-45years old (15.6%). Clinically, 60% of patients' hade single lesion with 1.55 average number of lesions. About 30.7% of patients' had indurated plaque type of lesion. Most of the lesions were found on head and face (59%). House near to farmland, presence of hyrax in the village and presence of other cutaneous leishmaniasis cases in the neighborhood were independent predicator of PLOS NEGLECTED TROPICAL DISEASES

Eight-Year Trend Analysis of Cutaneous Leishmaniasis Cases in West Amhara Region Referred to Amhara Public Health Institute Northwest, Ethiopia: A Retrospective Study

“…Our study revealed that 62.6% of the suspected cases were males. This study was in line with studies done at Borumeda Hospital, northeast Ethiopia [18,20], at Gondar University Hospital northwest Ethiopia [19,21], and in Tigray rural communities northern Ethiopia [22].…”

Successful Isolation of Leishmania RNA Virus (LRV) from Leishmania major in a Cutaneous Leishmaniasis Focus in Central Iran: An Update on Cases

“…However, L. tropica appears to be circulating in the study area, because the only patient with L. tropica lesion has not reported any travel history. Males (55%) outnumbered females, which is supported by other studies conducted in Iran, or overseas [30][31][32]. This may be in terms of their more exposure to the sand fly bites because of the type and time of their occupations and their less coverage, which makes males more prone to insect bites in general.…”

“…This may be in terms of their more exposure to the sand fly bites because of the type and time of their occupations and their less coverage, which makes males more prone to insect bites in general. Even though all age groups are affected by CL, but the disease was more prevalent in the age group 21-30 years (20%), because they spent more time outside as active workforce [7,31,32], and there was no patient under 1 year old. Corroborating with some other researches, which could be in terms of their complete coverage and staying mostly indoors, resulting in lesser contact with vectors, as well as the long latency of disease [4,31].…”

Knowledge, attitude and prevention measures of students towards cutaneous leishmaniasis in Delanta district, Northeast Ethiopia

“…Leishmaniasis is one of the major neglected tropical diseases primarily affecting peoples who are found in low socio-economical status ( World health Organization, 2021 ). Cutaneous leishmaniasis is a common health problem and it is highly prevalent in the northern and southern highland areas of Ethiopia ( Seid et al, 2014 ; Bisetegn et al, 2020 ). Peoples' awareness and perception towards leishmaniasis have its own impact to prevent the disease in endemic areas ( Alidosti et al, 2021 ).…”