Clinical Pathogenesis, Molecular Mechanisms of Gastric Cancer Development

Wroblewski, Lydia E.; Peek Jr, Richard M.

doi:10.1007/978-3-031-47331-9_2

Cited by 2 publications

(1 citation statement)

References 174 publications

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“…The Mongolian gerbil (Meriones unguiculatus) is a small mammal of the rodent Muridae family that has become a suitable laboratory model species [40]. As such, gerbils have been extensively used in the fields of aging [41][42][43], metabolism [44][45][46], infection [47,48], immune system [49,50], and cancer [51,52]. In neuroscience research, gerbils have been extensively used to study sensory systems [53][54][55][56][57][58], neurological diseases [54,[59][60][61] and brain structures [62][63][64].…”

Section: Introductionmentioning

confidence: 99%

Immunocytochemical localization of nitric oxide synthase-containing neurons in the visual cortex of the Mongolian gerbil

Kuai,

Jeong,

Jeon

2024

Folia Histochem Cytobiol.

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This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially. www.journals.viamedica.pl/folia_histochemica_cytobiologica ©Polish Society for Histochemistry and Cytochemistry

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Section: Introductionmentioning

confidence: 99%

Immunocytochemical localization of nitric oxide synthase-containing neurons in the visual cortex of the Mongolian gerbil

Kuai,

Jeong,

Jeon

2024

Folia Histochem Cytobiol.

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GRB7-mediated enhancement of cell malignant characteristics induced by Helicobacter pylori infection

Zhao,

Chen,

Bai

et al. 2024

Front. Microbiol.

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Growth factor receptor bound protein 7 (GRB7) is reportedly upregulated in human gastric cancer (GC), which is closely associated with tumor progression and prognosis. However, the mechanism underlying its dysregulation in GC remains poorly understood. In this study, we found that GRB7 overexpression was associated with Helicobacter pylori (H. pylori) infection. GC cells (AGS and MGC-803) infection assays revealed that this upregulation was mediated by the transcription factor STAT3, and activation of STAT3 by H. pylori promoted GRB7 expression in infected GC cells. Moreover, CagA, the key virulence factor of H. pylori, was found involved in STAT3-mediated GRB7 overexpression. The overexpressed GRB7 further promoted GC cell proliferation, migration, and invasion by activating ERK signaling. Mice infection was further used to investigate the action of GRB7. In H. pylori infection, GRB7 expression in mice gastric mucosa was elevated, and higher STAT3 and ERK activation were also detected. These results revealed GRB7-mediated pathogenesis in H. pylori infection, in which H. pylori activates STAT3, leading to increased GRB7 expression, then promotes activation of the ERK signal, and finally enhances malignant properties of infected cells. Our findings elucidate the role of GRB7 in H. pylori-induced gastric disorders, offering new prospects for the treatment and prevention of H. pylori-associated gastric carcinogenesis by targeting GRB7.

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Clinical Pathogenesis, Molecular Mechanisms of Gastric Cancer Development

Cited by 2 publications

References 174 publications

Immunocytochemical localization of nitric oxide synthase-containing neurons in the visual cortex of the Mongolian gerbil

Immunocytochemical localization of nitric oxide synthase-containing neurons in the visual cortex of the Mongolian gerbil

GRB7-mediated enhancement of cell malignant characteristics induced by Helicobacter pylori infection

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