Clinical/pathologic features and patient outcome in early onset endometrial carcinoma: A population based analysis and an institutional perspective from the Detroit metropolitan area, Michigan

Semaan, Assaad; Ali-Fehmi, Rouba; Munkarah, Adnan; Bandyopadhyay, Sudeshna; Morris, Robert T.; Rizk, Sara; Mert, İsmail; Ruterbusch, Julie J.; Coté, Michele L.

doi:10.1016/j.ygyno.2011.09.027

Cited by 10 publications

(9 citation statements)

References 14 publications

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“…24 Importantly, the incidence of endometrial cancer in young women has been rising steadily since the 1990’s. 25 Endometrial cancer in young women is often associated with obesity and nulliparity and is typically associated with a more favorable prognosis than in older women. 26,27…”

Section: Discussionmentioning

confidence: 99%

Racial disparities in young women with endometrial cancer

Mukerji

Baptiste

Chen

et al. 2018

Gynecologic Oncology

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Section: Discussionmentioning

confidence: 99%

Racial disparities in young women with endometrial cancer

Mukerji

Baptiste

Chen

et al. 2018

Gynecologic Oncology

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“…However, disease recurrence may occur and affect patient outcomes when clinical or pathological adverse factors are present. The conventional risk factors for recurrence in early stage endometrial cancer include tumor stage, increasing patient age, tumor size, high-risk histological type, grade 3 adenocarcinoma, myometrial invasion and lymphovascular space invasion (LVSI) [ 1 , 2 , 3 , 4 ], all of which have been associated with a higher risk of recurrence and nodal metastasis [ 2 , 4 , 5 , 6 , 7 ]. Among these adverse factors, a Gynecologic Oncology Group study reported that tumor grading was the greatest determinant of recurrence, with a relative risk of 15 for grade 3 adenocarcinoma [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathologic Features and Treatment Outcomes in Patients with Stage I, High-Risk Histology or High-Grade Endometrial Cancer after Primary Staging Surgery: A Taiwanese Gynecologic Oncology Group Study

Yen

Chen

et al. 2018

JCM

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To investigate the clinicopathological features and treatment outcomes in patients with stage I, high-risk endometrial cancer. Patients with International Federation of Gynecology and Obstetrics stage I, papillary serous, clear cell, or grade 3 endometrioid carcinoma treated between 2000 and 2012 were analyzed for the clinical and pathological factors in relation to prognosis. A total of 267 patients (stage IA; n = 175, stage IB; n = 92) were included. Among the clinicopathological features, stage and age were significant prognostic factors. The recurrence rate and overall survival for stage IB versus IA were 22.8% versus 9.1% (p = 0.003) and 149.7 months versus 201.8 months (p < 0.001), respectively. The patients >60 years of age also had a higher recurrence rate (21.7% versus 9.7%, p = 0.008) and poorer survival (102.0 months versus 196.8 months, p = 0.001) than those ≤60 years of age. Distant recurrence (64.9%) occurred more frequently than local recurrence (24.3%) and local combined with distant recurrence (10.8%) (p < 0.001). The postoperative treatment modality had no impact on tumor recurrence rate, recurrence site, or overall survival. Distant recurrence is a major cause of treatment failure in patients with stage I, high-risk endometrial cancer. However, current adjuvant treatment appeared to have little effect in preventing its occurrence.

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“…In a group of 181 patients with endometrial cancer described by Steiner et al, the effect of the histopathologic tumour type as an independent prognostic factor for recurrence-free survival and death was revealed, and these investigators found that patients with adenocarcinoma or adenoacanthoma had considerably higher overall survival and recurrencefree survival rates when compared to patients with other tumour forms like (papillary, clear-cell carcinoma, and others) (30,31) .…”

Section: Discussionmentioning

confidence: 99%

Treatment Outcomes of Uterine Carcinoma: A Single Institution Retrospective Study

Karim,

Fattah,

Ali

2023

JSMC

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BackgroundEndometrial cancer has a lifetime risk of 2.6% for women living in industrialized countries and it is the most prevalent kind of cancer diagnosed in those regions. In terms of gynecologic cancer-related deaths, it ranks after ovarian and cervical cancer as the third most common cause. ObjectivesTo evaluate endometrial cancer patients’ long-term treatment outcomes, including disease-free survival and overall survival, as well as to pinpoint independent predictive markers. Materials and MethodsAt the Zhianawa Cancer Center, a retrospective analysis was conducted. All patients who had been referred for radiation therapy between March 2009 and January 2019 were included in the research, except those who had distant metastases. In the end, 89 patients were included. Using the Kaplan-Meier technique, overall survival and disease-free survival were calculated, and the significance of the variations across curves was evaluated using the log-rank test. ResultsAll patients underwent surgery, 96.6% received adjuvant radiotherapy, and 42.7% received concomitant chemotherapy. The 5-year and 10-year disease-free survivals were 62.9% and 56.2%, and the overall 5-year and 10-year survivals were 74.2% and 66.3% respectively. The statistically significant variables impacting disease-free survival were lymphovascular invasion and marginal status, and the only statistically significant prognostic variable affecting overall survival was the FIGO stage. ConclusionIn this analysis, we concluded that uterine cancer has a good prognosis, and its outcome was influenced by stage, lymphovascular space invasion, and surgical marginal status.

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Clinical/pathologic features and patient outcome in early onset endometrial carcinoma: A population based analysis and an institutional perspective from the Detroit metropolitan area, Michigan

Cited by 10 publications

References 14 publications

Racial disparities in young women with endometrial cancer

Racial disparities in young women with endometrial cancer

Clinicopathologic Features and Treatment Outcomes in Patients with Stage I, High-Risk Histology or High-Grade Endometrial Cancer after Primary Staging Surgery: A Taiwanese Gynecologic Oncology Group Study

Treatment Outcomes of Uterine Carcinoma: A Single Institution Retrospective Study

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