Clinical Pathological Characteristics and Management of Acute Respiratory Distress Syndrome Resulting from Influenza A (H1N1) Virus

Homsi, Samer; Milojkovic, Natasa; Homsi, Yamen

doi:10.1097/smj.0b013e3181e6ca0c

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…c Il controllo a 71 giorni mostra la completa regressione delle residue aree consolidative con persistenza di ground-glass periferico bilateralmente ed aspetti reticolari esclusivamente ai lobi inferiori dorsalmente; notevolmente ridotti gli aspetti bronchiettasici. ), sia all'aberrante risposta immunitaria mediata dai linfociti T CD8 e dai linfociti B [9], e determina un quadro anatomopatologico-radiologico caratteristico, in cui si distinguono tre fasi ormai ben conosciute che si susseguono nel tempo [10][11][12][13][14][15]. 1.…”

Section: Discussionunclassified

Post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia: role of follow-up CT

et al. 2011

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In patients with H1N1 pneumonia, post-ARDS pulmonary fibrosis is not a rare complication. Therefore, a CT scan should be performed in all patients with severe clinical findings. Our study demonstrated that in these patients, fibrosis could present a different spatial distribution and a different temporal trend, with delayed late onset; moreover, in one case, the signs of interstitial lung disease partially regressed over time. Therefore, CT should be considered not only in the diagnostic stage, but also during the follow-up.

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Section: Discussionunclassified

Post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia: role of follow-up CT

et al. 2011

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“…Influenza virus infection in humans was reported to cause acute respiratory distress syndrome (ARDS) (10). Moreover, approximately 6-8% of patients with chronic H1N1 influenza infection also developed diffuse alveolar damage and pulmonary fibrosis (2,11). Although TGF-b and FasL were shown to be involved in ARDS-induced tissue remodeling and fibrosis (12,13), whether these two potent fibrotic mediators are involved in influenza virus-induced fibroproliferative ARDS remains unclear.…”

mentioning

confidence: 99%

Influenza Induces Endoplasmic Reticulum Stress, Caspase-12–Dependent Apoptosis, and c-Jun N-Terminal Kinase–Mediated Transforming Growth Factor–β Release in Lung Epithelial Cells

Roberson

Tully²,

Guala³

et al. 2012

Am J Respir Cell Mol Biol

116

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Influenza A virus (IAV) infection is known to induce endoplasmic reticulum (ER) stress, Fas-dependent apoptosis, and TGF-β production in a variety of cells. However, the relationship between these events in murine primary tracheal epithelial cells (MTECS), which are considered one of the primary sites of IAV infection and replication, is unclear. We show that IAV infection induced ER stress marker activating transcription factor-6 and endoplasmic reticulum protein 57-kD (ERp57), but not C/EBP homologous protein (CHOP). In contrast, the ER stress inducer thapsigargin (THP) increased CHOP. IAV infection activated caspases and apoptosis, independently of Fas and caspase-8, in MTECs. Instead, apoptosis was mediated by caspase-12. A decrease in ERp57 attenuated the IAV burden and decreased caspase-12 activation and apoptosis in epithelial cells. TGF-β production was enhanced in IAV-infected MTECs, compared with THP or staurosporine. IAV infection caused the activation of c-Jun N-terminal kinase (JNK). Furthermore, IAV-induced TGF-β production required the presence of JNK1, a finding that suggests a role for JNK1 in IAV-induced epithelial injury and subsequent TGF-β production. These novel findings suggest a potential mechanistic role for a distinct ER stress response induced by IAV, and a profibrogenic/repair response in contrast to other pharmacological inducers of ER stress. These responses may also have a potential role in acute lung injury, fibroproliferative acute respiratory distress syndrome, and the recently identified H1N1 influenza-induced exacerbations of chronic obstructive pulmonary disease (Wedzicha JA. Proc Am Thorac Soc 2004;1:115-120) and idiopathic pulmonary fibrosis (Umeda Y, et al. Int Med 2010;49:2333-2336).

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“…This acute medical condition usually occurs during first two days of the precipitating diseases and with high mortality or long term consequence in survivors ( 7 ). Influenza A /H1N1 infection can develop severe type of ARDS with very high mortality ( 8 , 9 , 10 ). Despite of progress in the management of ARDS mortality still remains high.…”

Section: Discussionmentioning

confidence: 99%

“…We observed in our cases delayed recognition diagnostic criteria for ARDS and antiviral therapy which is general observation for clinicians in practice ( 12 ). Wider dissemination of new definition of ARDS is recommended ( 4 , 6 , 10 , 12 ).…”

Section: Discussionmentioning

confidence: 99%

Acute Respiratory Distress Syndrome (ARDS) from Endemic Influenza A/H1N1: Prehospital Management

Salihefendić¹,

Zildžić²,

Ahmetagić³

2015

Med Arh

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Acute respiratory distress syndrome (ARDS) is a form of acute life threatening respiratory failure. In daily practice there is difficulty in diagnostic and therapeutic management of Acute respiratory distress syndrome (ARDS). We observed delay in diagnostic and therapeutic procedures in patients with clinical signs for the presence of severe respiratory disorders. Finding timely evidence of the presence the clinical signs of threatening ARDS and underlying diseases like influenza A/H1N1 during prehospital period in early stage of disease it is possible introduce early adequate treatment: high flow oxygen, fluid replacement and pharmacological and antiviral therapy. This measure can reduce high mortality in patients who develop ARDS. It is important to improve diagnostic criteria for a precise definition of ARDS and transfer it in practice of emergency and family medicine, microbiology, intensive care units, hospital departments of infectious and respiratory diseases. In this article we underlined the key elements of the new definition of ARDS, diagnostic criteria and the importance of early diagnosis in prehospital period following clinical feature and course (a presence of severe dyspnea) by adding chest x-ray and laboratory investigations.

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Clinical Pathological Characteristics and Management of Acute Respiratory Distress Syndrome Resulting from Influenza A (H1N1) Virus

Cited by 7 publications

References 21 publications

Post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia: role of follow-up CT

Post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia: role of follow-up CT

Influenza Induces Endoplasmic Reticulum Stress, Caspase-12–Dependent Apoptosis, and c-Jun N-Terminal Kinase–Mediated Transforming Growth Factor–β Release in Lung Epithelial Cells

Acute Respiratory Distress Syndrome (ARDS) from Endemic Influenza A/H1N1: Prehospital Management

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