Clinical Pathology

Monteiro, Carla; Brandão, João

doi:10.1002/9781119149262.ch11

Exotic Animal Emergency and Critical Care Medicine 2021

DOI: 10.1002/9781119149262.ch11

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Clinical Pathology

Carla Monteiro¹,

João Brandão

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2024

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Cited by 1 publication

References 62 publications

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Dual‐Layer Nanoengineered Urinary Catheters for Enhanced Antimicrobial Efficacy and Reduced Cytotoxicity

Won,

Lee,

Park

et al. 2024

Adv Healthcare Materials

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Catheter‐associated urinary tract infection (CAUTI) is the most common healthcare‐associated infection; however, current therapeutic strategies remain insufficient for standard clinical application. A novel urinary catheter featuring a dual‐layer nanoengineering approach using zinc (Zn) and silver nanoparticles (AgNPs) is successfully fabricated. This design targets microbial resistance, minimizes cytotoxicity, and maintains long‐term efficacy. The inner AgNPs layer provides immediate antibacterial effects against the UTI pathogens, while the outer porous Zn layer controls zero‐order Ag release and generates reactive oxygen species, thus enhancing long‐term bactericidal performance. Enhanced antibacterial properties of Zn/AgNPs‐coated catheters are observed, resulting in 99.9% of E. coli and 99.7% of S. aureus reduction, respectively. The Zn/AgNPs‐coated catheter significantly suppresses biofilm with sludge formation compared to AgNP‐coated and uncoated catheters (all, p < 0.05). The Zn/AgNP‐coated catheter in a rabbit model demonstrated a durable, effective barrier against bacterial colonization, maintaining antimicrobial properties during the catheter indwelling period with significantly reduced inflammation and epithelial disruption compared with AgNP and uncoated groups. This innovation has the potential to revolutionize the design of antimicrobial medical devices, particularly for applications requiring long‐term implantation. Although further preclinical studies are required to verify its efficacy and safety, this strategy seems to be a promising approach to preventing CAUTI‐related complications.

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Dual‐Layer Nanoengineered Urinary Catheters for Enhanced Antimicrobial Efficacy and Reduced Cytotoxicity

Won,

Lee,

Park

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

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Clinical Pathology

Cited by 1 publication

References 62 publications

Dual‐Layer Nanoengineered Urinary Catheters for Enhanced Antimicrobial Efficacy and Reduced Cytotoxicity

Dual‐Layer Nanoengineered Urinary Catheters for Enhanced Antimicrobial Efficacy and Reduced Cytotoxicity

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