Clinical Pathology Reference Ranges of Laboratory Animals.

Proteases and Protease Inhibitors in Cerulein-Induced Acute Pancreatitis in Rats

“…By using specific antisera and electroimmunoassay, normal plasma levels in rats are 35 g/L for albumin [15] and 3.7 g/L for ␣ 1 -macroglobulin [16,17]. By using chromogenic peptide substrates, normal plasma levels for the other plasma proteins are all 100 Ϯ 20% of the reference standard pool.…”

Effects of <i>Aster scaber</i> Seed Oil Containing <i>trans</i>-Δ3 Fatty Acids on Lipid Profiles of Hamsters and Rats

“…The concentration of serum malondialdehyde MDA was significantly lower in the ASO-fed group than it was in the other groups. There were no differences in serum GOT and GPT activities among the groups; the activity levels of serum GOT and GPT were in the normal range 17 .…”

Toxicity Screening After Repeated Dose of a Newly Developed Oral Heparin Derivative in Male Cynomolgus Monkeys

“…Hematological parameters were not affected by the test article. Minor changes in WBC number at Day 1 and Day 4 were considered incidental and within the range of normal variability for the parameter (Matsuzawa et al, 1993;Kim et al, 2004), or were related to study procedures (e.g., blood sampling and animal handling). As shown in Table 5, platelet-related parameters were also not affected by the test article.…”

“…Serum chemistry parameters were not affected by the test article (Table 7). A decrease in serum biochemical parameter of AST level at Day 7 was considered incidental and within the range of normal variability for the parameter (Matsuzawa et al, 1993;Kim et al, 2004). The present finding that the two-week repeated dose of the test article did not affect any effects in hematological and serum biochemical parameters was consistent with that found in the previous study, in which a single dose of the test article did not show any change in body weights, hematological and serum biochemical parameters at a dose of 500 mg/kg (Kim et al, 2007).…”