Process mining (PM) is a well-known research area that includes techniques, methodologies, and tools for analyzing processes in a variety of application domains. In the case of healthcare, processes are characterized by high variability in terms of activities, duration, and involved resources (e.g., physicians, nurses, administrators, machineries, etc.). Besides, the multitude of diseases that the patients housed in healthcare facilities suffer from makes medical contexts highly heterogeneous. As a result, understanding and analyzing healthcare processes are certainly not trivial tasks, and administrators and doctors look for tools and methods that can concretely support them in improving the healthcare services they are involved in. In this context, PM has been increasingly used for a wide range of applications as reported in some recent reviews. However, these reviews mainly focus on discussion on applications related to the clinical pathways, while a systematic review of all possible applications is absent. In this article, we selected 172 papers published in the last 10 years, that present applications of PM in the healthcare domain. The objective of this study is to help and guide researchers interested in the medical field to understand the main PM applications in the healthcare, but also to suggest new ways to develop promising and not yet fully investigated applications. Moreover, our study could be of interest for practitioners who are considering applications of PM, who can identify and choose PM algorithms, techniques, tools, methodologies, and approaches, toward what have been the experiences of success.