Clinical patterns and associated comorbidities of vitiligo in Kandahar, Afghanistan. A case-control study

Background: Healthy skin with integrity is essential for maintaining one’s physical, mental, and social wellbeing. Vitiligo, a chronic autoimmune dermatosis characterized by asymptomatic, achromic macules, affects the integrity of the skin. Methodology: This was a descriptive, cross-sectional study conducted from March to June 2019 in six public hospitals in the city of Ouagadougou, Burkina Faso. The patients included in the study were followed in the dermatology departments of these structures for vitiligo, aged at least eighteen years and consenting. The Dermatology Life Quality Index (DLQI) and the vitiligo-specific health-related quality of life scale (VitiQoL) were employed to measure QoL (quality of life). Results: A total of fifty patients agreed to participate in the study. The mean age was 40.56 years, ranging from 18 to 79 years. There were as many females as males (25), and 23 married patients out of the fifty. The majority of the patients (43/50) resided in urban areas. Twenty-six patients had at least secondary education and eighteen patients worked in the informal sector. The average duration of vitiligo progression was 10.56 years, ranging from three months to 49 years. The evolution of vitiligo was stationary for 17/50 patients. The lesions were mainly located on the head and neck. The average body surface area (BSA) affected was 12.04%, ranging from 1% to 82%. The treatment was mainly local and general corticosteroid therapy. The evaluation of the patients’ quality of life (QoL) by the DLQI (Dermatology Life Quality Index) yielded a mean score of 5.44/30. Vitiligo had a small effect on the QoL of eighteen patients and a moderate effect on sixteen patients. VitiQoL assessment yielded a mean total score of 32.32/96 and stigma had the highest score of 18.04/36. The patients’ QoL was influenced by age and body surface area affected by vitiligo. Restriction of participation in activities and changes in the patient’s behavior were significantly correlated with the duration of vitiligo progression, followed by stigma, which was related to vitiligo progression. Conclusion: The alteration of the QoL of the patients with vitiligo was low to moderate. This alteration was related to the stigmatization by one’s environment.

“…Boza made the same finding in their study cited above (14.23; 16.75; 9.15; and 3.6) [12]. Rahimi also mentioned the same [19].…”

Section: Quality Of Lifesupporting

confidence: 80%

“…However, females were more affected than males with higher scores. Other authors reported the same findings [6,10,16,19].…”

Section: Quality Of Lifesupporting

confidence: 64%

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Vitiligo and quality of life: On fifty cases in Ouagadougou, Burkina Faso

Ouédraogo¹,

Ouédraogo²,

Tapsoba³

et al. 2022

“…Kikuchi et al reported hyperuricemia in vitiligo patients who have undergone narrowband UVB therapy. The immunomodulatory effect of UV radiation affects T lymphocytes, which attack melanocytes, resulting in increased nucleic acid turnover, thus causing hyperuricemia [5,6]. Therefore, the sun exposure in our patient, who had had vitiligo since childhood, might have been responsible for the increased uric acid levels and gouty tophi.…”

mentioning

confidence: 80%

Gout nodules in vitiligo without chronic gouty arthritis: A rare presentation

Deepak¹,

Gayatridevi²,

Alluri³

et al. 2020

Gouty tophi present themselves as firm and skincolored or yellowish papules or nodules with white chalky material. They may appear in any location on the body, but appear most commonly in the interphalangeal joints [1]. Clinically, they may resemble calcinosis cutis, rheumatoid nodules, xanthomas, and panniculitis. They indicate a chronic foreign-body granulomatous response to monosodium urate crystal deposits in the dermis and the subcutaneous tissue, and classically occur with untreated chronic gouty arthritis. Very rarely, in the absence of arthritis, they may be the first clinical sign of gout, which is known as gout nodulosis [2].

“…Vitiligo has been associated with a spectrum of autoimmune conditions such as alopecia areata, thyroid disease, pernicious anaemia, Addison's disease and rarely systemic lupus erythematosus [2]. Ying Jin et al identified several chromosomal regions that appear to contribute to this epidemiological association including chromosome 17p13 [3].…”

Section: Discussionmentioning

confidence: 99%

Discoid lupus erythematosus co-existent with vitiligo patches on the scalp: A case report

Hassanandani¹,

Behera²,

Panda³

et al. 2020

Discoid lupus erythematosus, a type of chronic cutaneous lupus erythematosus presents as scaly plaques mostly over sun exposed parts of the body. Vitiligo is characterized by depigmented patches. Coexistence of the two is a rare phenomenon. There have been few reports of DLE coexisting with vitiligo over acral parts but to the best of our knowledge none of them were present over the scalp. Here we present a case of coexistence of DLE and vitiligo lesions over the scalp of an adult male and the challenge in therapy of the two conditions occurring simultaneously over the scalp.