Clinical performance and biocompatibility of poly(2-methoxyethylacrylate)—coated extracorporeal circuits

Günaydın, Serdar; Farsak, Bora; Kocakulak, Mustafa; Sarı, Tamer; Yorgancioglu, Cem; Zorlutuna, Yaman

doi:10.1016/s0003-4975(02)03796-7

Cited by 54 publications

(47 citation statements)

References 7 publications

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“…Also, in our previous studies, we have demonstrated data clarifying the platelet preservation effects of polymer coating. 29 In this study, we aimed at using dual-effect to overcome AF occurrence; filtration of activated leukocytes and blood management. Post-operative bleeding was less in the study group and inflammatory markers demonstrated better clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Clinical effects of leukofiltration and surface modification on post-cardiopulmonary bypass atrial fibrillation in different risk cohorts

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Clinical effects of leukofiltration and surface modification on post-cardiopulmonary bypass atrial fibrillation in different risk cohorts

et al. 2007

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“…Reduced circuits with less priming volume and the lack of venous reservoir are associated to decreased cytokine release, neutrophil and platelet activation 42 . Poly-coated circuits (2-methoxyethylacrylate) have been related to lower inflammatory reaction 43 . It is still necessary to establish direct causal links between postoperative or post-CPB inflammatory response, physiological pulmonary changes during MR with CPB and patients' clinical evolution.…”

Section: Discussionmentioning

confidence: 99%

“…A utilização de circuitos reduzidos com menor volume de primming, a ausência de reservatório venoso está associada à redução da liberação de citocinas, da ativação neutrofílica e plaquetária 42 . Circuitos recobertos com Poly (2-methoxyethylacrylato) foram relacionados com menor reação inflamatória 43 . Ainda é necessário o estabelecimento de ligações causais diretas entre a resposta inflamatória após cirurgia ou CEC, alterações na fisiologia pulmonar durante a cirurgia de RM com CEC e a evolução clínica dos pacientes.…”

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Análise da celularidade do lavado bronco-alveolar em pacientes submetidos à revascularização do miocárdio com circulação extracorpórea: relato de três casos

Machado¹,

Santos²,

Negri³

et al. 2006

Rev. Bras. Anestesiol.

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RESUMOMachado LB, Santos LM, Negri EM, Malbouisson LMS, Auler Jr JOC, Carmona MJC -Análise da Celularidade do Lavado Bronco-Alveolar em Pacientes Submetidos à Revascularização do Miocárdio com Circulação Extracorpórea. Relato de Três Casos JUSTIFICATIVA E OBJETIVOS: A circulação extracorpórea (CEC) é um dos principais determinantes da resposta inflamatória sistêmica (SIRS) em cirurgia cardíaca. Demonstrou-se em modelo experimental que a CEC pode levar a aumento na produção das citocinas. No intuito de avaliar a ativação celular no pulmão após CEC, foi estudada a celularidade no lavado bronco-alveolar (LBA) em pacientes submetidos à cirurgia de revascularização do miocárdio (RM) com CEC. RELATO DOS CASOS:Foram estudados, prospectivamente, três pacientes adultos submetidos à RM com CEC. Após indução de anestesia geral e intubação traqueal, a ventilação mecânica foi realizada com sistema circular valvular; exceto durante a CEC, o volume corrente foi mantido entre 8 e 10 mL.kg -1 com O 2 e ar, numa proporção de 50%. Antes do despinçamento da aorta, foram realizadas insuflações pulmonares com pressão de 40 cmH 2 O e coletadas duas amostras de LBA de cada paciente, no início da intervenção cirúrgica e ao final do procedimento, após a reversão da anticoagulação. Após a infusão de 60 mL de solução fisiológi-ca a 0,9% pelo canal do broncofibroscópio, foi aspirado o LBA, Análise sendo o material encaminhado para processamento laboratorial. A análise evidenciou aumento do número total de células, em média, de 0,6.10 6 cél.dL -1 para 6,8.10 6 cél.dL -1 com aumento de neutrófilos de 0,8% para 4,7%; 0,6% para 6,2% e 0,5% para 5,3% em cada paciente, respectivamente. Observou-se na lâmina o aumento de celularidade no fluido pulmonar após a CEC. CONCLUSÕES: O influxo leucocitário é descrito em diversas condições clínicas pulmonares inflamatórias, como na síndrome da angústia respiratória do adulto. Sabe-se que a CEC está relacionada com a inflamação sistêmica e pulmonar, demonstrando aumento do número de células após a CEC com o predomínio de macrófagos.Unitermos: CIRURGIA, Cardíaca: circulação extracorpórea, revascularização; COMPLICAÇÕES: reação inflamatória pulmonar. SUMMARYMachado LB, Santos LM, Negri EM, Malbouisson LMS, Auler Jr JOC, Carmona MJC -Broncho-Alveolar Lavage Cellularity in Patients Submitted to Myocardial Revascularization with Cardiopulmonary Bypass. Three Case Reports BACKGROUND AND OBJECTIVES: Cardiopulmonary bypass (CPB) is a primary determinant of systemic inflammatory response (SIRS) during cardiac procedures. It has been shown in an experimental model that CPB may increase cytokine production. This study aimed at evaluating post-CPB lung cell activation by investigating broncho-alveolar lavage (BAL) cellularity in patients submitted to myocardial revascularization (MR) with CPB. CASE REPORTS: Participated in this prospective study 3 adult patients submitted to MR with CPB. After general anesthesia induction and tracheal intubation, mechanical ventilation was installed with valve circle system; except dur...

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“…There were more leukocytes adhered on noncoated (60 cells/dL) than on the coated (14 cells/dL) oxygenator fibers. It appears that with less protein adsorption, [16][17][18] fewer leukocytes adhered to the coated fibers.…”

Section: Stm Studiesmentioning

confidence: 99%

“…In previous studies, we found that more platelets adhered to the noncoated fiber surfaces. [16][17][18] The adsorbed immunoglobulin and adhered leukocytes on foreign surfaces triggered complement activation via the alternative pathway. Complement activation on PMEA-coated surfaces was less due to less IgG adsorption and leukocyte adhesion.…”

Section: Stm Studiesmentioning

confidence: 99%

Investigation of inflammatory response at blood–poly (2-methoxyethyl acrylate) (PMEA) interface in vivo via scanning tunneling microscope

Kocakulak

Kocum

Ayhan

2011

Journal of Bioactive and Compatible Polymers

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The effects of an amphiphilic polymer coating of poly(2-methoxyethyl acrylate) (PMEA) on immunoglobulin adsorption and leukocyte adhesion were investigated. Forty patients were operated on using noncoated and PMEA-coated oxygenator fibers; leukocyte counts adhered onto the noncoated and coated fibers. It appears that the adsorbed immunoglobulin on noncoated fiber surfaces plays a role in leukocyte adhesion and complement activation by an alternative pathway, while the PMEA coating reduced the complement activation on the oxygenator hollow fibers. The biomaterial and blood interaction at the interface could potentially be used as an indicator for predicting the artificial devices long-term clinical performance.

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Clinical performance and biocompatibility of poly(2-methoxyethylacrylate)—coated extracorporeal circuits

Cited by 54 publications

References 7 publications

Clinical effects of leukofiltration and surface modification on post-cardiopulmonary bypass atrial fibrillation in different risk cohorts

Clinical effects of leukofiltration and surface modification on post-cardiopulmonary bypass atrial fibrillation in different risk cohorts

Análise da celularidade do lavado bronco-alveolar em pacientes submetidos à revascularização do miocárdio com circulação extracorpórea: relato de três casos

Investigation of inflammatory response at blood–poly (2-methoxyethyl acrylate) (PMEA) interface in vivo via scanning tunneling microscope

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