Clinical Performance and Remineralization Potential of Different Biomimitic Materials on White Spot Lesions

Kamh, Raghda; Niazy, Maha A.; Elyasaky, Mohamed A.

doi:10.21608/adjg.2018.20020

Cited by 14 publications

(14 citation statements)

References 22 publications

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“…As for the qualitative analysis using ICDAS, there is harmony between the results of the current study and the clinical study that was verified by other researchers [ 3 ] who measured early enamel lesion changes visually, via ICDAS II scoring. SAP showed a statistically significant improvement in reversing the lesion, over fluoride after 3 months of application.…”

Section: Discussionsupporting

confidence: 78%

“…The reason for the white appearance is the changes in light-scattering optical properties of the decalcified enamel. Various risk factors such as acid-producing bacteria, fermentable carbohydrates, and many host factors, such as poor oral hygiene, low salivary volume, and a sugary diet, further contribute to the development of these incipient lesions [ 3 ]. One of the host risk factors is the fixed orthodontics appliances: namely, brackets, bands, wires, and other applications add up more plaque retention sites and thus make oral hygienic measures more difficult [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial

2022

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Objectives To evaluate the clinical performance of self-assembling peptides versus fluoride-based delivery systems in post-orthodontic white spot lesions. Materials and methods The participants were randomly assigned into two groups (n = 58) according to the remineralizing agent used, where (A) group represented participants receiving a varnish containing 22.600 fluoride ppm and tricalcium phosphate, while the second group (B) represented participants receiving self-assembling peptide. The remineralizing process of the white spot lesion was assessed using the DIAGNOdent pen and ICDAS scoring system according to the time when the remineralizing agent was used (T), where T0 represented the score taken at baseline. T1 represented the score taken after 3 months of follow-ups and T2 score represented the score taken after 6 months of follow-up. Data were collected and statistically analyzed. The parametric data: two-way ANOVA was used to test the effect of interaction among different variables. The non-parametric data: Mann–Whitney test was used. The significance level was set at p ≤ 0.05. Results There was a quantitative statistically significant difference via DIAGNOpen readings between Group A (fluoride material) and Group B (self-assembling peptides). The highest mean value of 10.51 was found in Group A, while the least mean value of 6.45 was found in Group B. Besides, there was a significant difference in each group concerning the time factors T0, T1, and T2 groups where (p < 0.001. As for the qualitative results concerning the ICDAS score, there was no significant difference between the two groups along with the follow-up periods T0, T1, and T2 where the p value is equal to 0.064, 0.087, and 0.277 respectively. Conclusions The visual assessment using ICDAS reveals that the biomimetic remineralization using self-assembling peptides and the fluoride-based varnish material showed a similar effect in masking post-orthodontic white spot lesions. However, the laser fluorescence using DIAGNOpen showed that the self-assembling peptides reveal higher performance in subsurface remineralization than the fluoride-based varnish material. Therefore, self-assembling peptides are considered a promising material for lesion regression in post-orthodontics white spot lesions. Clinical relevance Self-assembling peptide SAP-14 is a new approach to reverse and mask off post-orthodontics white spot lesions.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial

2022

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“…As there are tragically few therapeutic agents for dental caries, it is exciting that there are ten clinical trials demonstrating an anti-caries effect by CR. 33–36,39,40,44,49–51 Clinical trials supporting other brush-on treatments for caries include those of traditional fluorides, sealants (including resin-infiltration), and SDF (including silver nitrate and fluoride varnish). 18,52 This is perilously insufficient, considering that caries is the most common disease in humans.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P₁₁-4 on Initial Caries Lesions

Keeper

Skaret²,

Thakkar‐Samtani

et al. 2022

Preprint

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Background: Dental caries remains a global problem that causes disproportionate suffering in underserved populations. Simple interventions are needed to improve patient experience, clinical and cost-effectiveness, and access to care. The self-assembling peptide P11-4 is a recently developed, non-invasive treatment that regenerates enamel in initial caries lesions. Studies reviewed: We conducted a systematic review and meta-analysis on the effectiveness of the P11-4 products CurodontTM Repair (CR) and CurodontTM Repair Fluoride Plus (CRFP) on initial caries lesions. Primary outcomes were lesion progression after 24 months, caries arrest, and cavitation. Secondary outcomes were changes in merged International Caries Detection and Assessment System (ICDAS) score, Quantitative Light Fluorescence, esthetic appearance, and lesion size. Results: Six clinical trials comparing CR to controls met the inclusion criteria. Results of this review represent two primary and two secondary outcomes. When compared to parallel groups, CR improved caries arrest (RR: 1.82; 95% CI: 1.32 to 2.50; 45% attributable risk; 95% CI: 24 to 60%) and decreased lesion size by 32% (Hedge g: -0.59; CI: -1.03 to -0.15). We observed positive trends for avoiding cavitation (RR: 0.32; CI: 0.10 to 1.06) and lowering merged ICDAS score (RR: 3.68; CI: 0.42 to 32.3). No studies used CRFP or reported adverse esthetic changes. Practical implications: CR has a treatment effect on caries arrest and decreased lesion size. Two trials contributing to the caries arrest result had non-masked assessors, and all trials had elevated risks of bias. We recommend conducting longer trials. CR is a promising treatment for initial caries lesions.

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“…The progression of dental caries occurred when the demineralization exceeds remineralization (12) . Re-mineralization is a procedure whereby calcium and phosphate ions are supplied from an external source to tooth enamel (13) . Developing countries need biocompatible and cost effective preventive methods due to their financial situations.…”

Section: Discussionmentioning

confidence: 99%

The Remineralizing Potential of Some Natural Materials Alone or Combined with Zamzam water on Demineralized Enamel

Abdo¹,

Niazy

Gad

2021

ADJ-for Girls

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Purpose: This study was designed to investigate the remineralizing potential of some natural materials (Honey, Whey extract, Zamzam water) versus synthetic product (fluoride tooth paste) on demineralized enamel. Materials and methods: A total of 40 premolars were extracted from 11-14 years old patients. Teeth were washed with distilled water to remove debris; and stored in distilled water contain 0.1% mg thymol.Forty samples were sectioned into two parts (buccal and lingual) then divided into four main groups (20 each) according to materials used; A1: Ginger & honey, A2:Whey extract, A3:Zamzam water & ginger and A4:Fluoride tooth paste. The four groups were further subdivided into two subgroups according to the time of assessment; B1: after 20 days and B2: after 40 days. All samples were treated by demineralizing solution Coca-Cola for 8 minutes, then the samples were mounted and tested materials were applied. Samples were examined with polarized light microscopy. Results: After 20 days, the results revealed that the highest mean value of microhardness was recorded for ginger& zamzam water (273.39), followed by whey extract (256.63), followed by Ginger & honey groups (249.20) while Fluoride group showed the lowest mean of microhardness (219.56). This difference was statistically significant. After 40 days, the results revealed that the highest mean value of microhardness was recorded for Ginger & Zamzam water (266.89), followed by Ginger & honey (260.39), followed by Whey extract group (251.16) while Fluoride group showed the lowest mean of microhardness (226.44). This difference was statistically significant. Conclusion: Natural materials have remineralizing effect on enamel of tooth.

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Clinical Performance and Remineralization Potential of Different Biomimitic Materials on White Spot Lesions

Cited by 14 publications

References 22 publications

Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial

Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P₁₁-4 on Initial Caries Lesions

The Remineralizing Potential of Some Natural Materials Alone or Combined with Zamzam water on Demineralized Enamel

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Clinical Performance and Remineralization Potential of Different Biomimitic Materials on White Spot Lesions

Cited by 14 publications

References 22 publications

Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial

Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial

Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P11-4 on Initial Caries Lesions

The Remineralizing Potential of Some Natural Materials Alone or Combined with Zamzam water on Demineralized Enamel

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Systematic Review and Meta-Analysis on the Effect of Self-Assembling Peptide P₁₁-4 on Initial Caries Lesions