Clinical performance of daily disposable soft contact lenses using sustained release technology

Peterson, Rachael C.; Wolffsohn, James S.; Nick, Joachim; Winterton, Lynn; Lally, John M.

doi:10.1016/j.clae.2006.03.004

Cited by 106 publications

(54 citation statements)

References 22 publications

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“…1,6 Soft contact lenses have become a valuable tool in the management of many ophthalmic disorders. [8][9][10] Contact lenses can be loaded with medications by presoaking them in a medication solution for therapeutic applications. However, contact lenses presoaked in medications provide a marginal means of delivery because therapeutics freely dis-persed within the contact lens structure are rapidly released (i.e., burst-release), often leading to increased topical drug side effects and toxicity reactions.…”

Section: Introductionmentioning

confidence: 99%

“…5 Thus, there is a need for new ophthalmic drug delivery systems that increase the residence time of the drug into the eye region, thereby reducing wastage and decreasing side effects. 2 Several types of ophthalmic drug delivery systems have been proposed to provide a sustained release over time, and these include hydrogels, 6 cyclodextrins, 7 collagen shields, and contact lenses, [8][9][10] used either alone or loaded with therapeutic agents, and colloidal systems suspended in a liquid or ointment carrier. [11][12][13] However, most hydrogels offer only moderate to marginal improvement of ocular drug bioavailability and can cause blurred vision.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and characterization of contact lenses bearing surface‐immobilized layers of intact liposomes

Danion

Brochu

Martin

et al. 2007

J Biomedical Materials Res

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Intact liposomes were immobilized onto soft contact lenses. In the first step, polyethylenimine was covalently bounded onto the hydroxyl groups available on the surface of a commercial contact lens (Hioxifilcon B). Then, NHS-PEG-biotin molecules were bounded onto the surface amine groups by carbodiimide chemistry. NeutrAvidin were bounded onto the PEG-biotin layer. Liposomes containing PEG-biotinylated lipids were docked onto the surface-immobilized NeutrAvidin. Consecutive addition of further NeutrAvidin and liposome layers enabled fabrication of multilayers. Multilayers of liposomes were also produced by exposing contact lenses coated with NeutrAvidin to liposome aggregates produced by the addition of free biotin in solution. XPS revealed the immobilization of the different layers. By blocking with excess biotin surface-immobilized NeutrAvidin on contact lenses bearing PEG-biotin layers produced under cloud point conditions, ELISA showed that the docking of NeutrAvidin was dependent on biotin-NeutrAvidin affinity binding, with little evidence for nonspecific physisorption; however, it was not possible to differentiate specific versus nonspecific binding of NeutrAvidin attached onto PEG-biotin layers grafted without cloud point conditions. AFM imaging revealed liposome sizes of 106 and 155 nm for layers of liposomes produced (i) by the consecutive addition of further NeutrAvidin and liposomes and (ii) by the exposure of NeutrAvidin-coated contact lenses to liposome aggregates, respectively. The release kinetics of a fluorescent dye demonstrated that intact liposomes had been immobilized onto contact lens surfaces. The stability of surface-immobilized liposomes onto contact lens surfaces showed temperature dependence. Surface-bound liposomes can be stored up to 1 month at 4 degrees C with little release of their content.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of contact lenses bearing surface‐immobilized layers of intact liposomes

Danion

Brochu

Martin

et al. 2007

J Biomedical Materials Res

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“…Soft contact lens-based DDSs have been investigated by several approaches: (1) Soak and absorption of drug solution [86]; (2) piggyback contact lens combined with a drug plate or drug solution [87]; (3) surface-modification to immobilize drugs on the surface of contact lenses [88]; (4) incorporation of drugs in a colloidal structure dispersed in the lens [89]; (5) ion ligand-containing polymeric hydrogel [90]; and (6) molecularly imprinting of drugs [91,92].…”

Section: Contact Lensmentioning

confidence: 99%

Recent Advances in Ocular Drug Delivery Systems

2011

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Abstract:Transport of drugs applied by traditional dosage forms is restricted to the eye, and therapeutic drug concentrations in the target tissues are not maintained for a long duration since the eyes are protected by a unique anatomy and physiology. For the treatment of the anterior segment of the eye, various droppable products to prolong the retention time on the ocular surface have been introduced in the market. On the other hand, direct intravitreal implants, using biodegradable or non-biodegradable polymer technology, have been widely investigated for the treatment of chronic vitreoretinal diseases. There is urgent need to develop ocular drug delivery systems which provide controlled release for the treatment of chronic diseases, and increase patient's and doctor's convenience to reduce the dosing frequency and invasive treatment. In this article, progress of ocular drug delivery systems under clinical trials and in late experimental stage is reviewed.

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“…11 There have been and continue to be multiple challenges in developing contact lenses as an ocular drug delivery system. [12][13][14][15][16] The current challenges include incorporation of sufficient amounts of the target drug into the lens matrix, sustaining a controlled drug release for the desired time frame, good optical clarity, patient comfort during prolonged wear, and biocompatibility. Various methods have been proposed for loading the target drug into a lens delivery system.…”

mentioning

confidence: 99%

Development and Efficacy of a Drug-Releasing Soft Contact Lens

Kakisu

Matsunaga²,

Kobayakawa

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The purpose of this study was to investigate the uptake and the release of antibiotics from a newly synthesized drug delivery hydrogel soft contact lens (SCL) using an ion ligand mechanism.METHODS. The antibiotics used were Gatifloxacin (GFLX) and Moxifloxacin (MFLX). The uptake amount and the sustained-release kinetics of antibiotics were investigated in vitro, and were also compared with newly synthesized SCLs, etafilcon A and polymacon. The antibiotic concentrations in the cornea, aqueous humor, and crystalline lens, and the effect against bacterial proliferation were investigated in vivo using rabbit subjects. Additionally the drug release efficacy of the new SCL was compared with that of eye drop administrations.RESULTS. In vitro, antibiotic uptake was increased with the weight percent (wt%) of the anionic group, and the released amount of antibiotics was highest during the initial 1 hour period, which then decreased over the next 72 hours. The released antibiotics volume of the new SCLs was significantly higher throughout 72 hours than that of the other two materials, etafilcon A and polymacon (P < 0.01). Whereas in vivo, the concentrations found in the cornea and aqueous humor were higher than those for the eye drop groups (P < 0.05 or P < 0.01). Antibiotic release at those sites decreased over 72 hours. No bacterial populations were detectable in the group treated with the new SCL presoaked in antibiotics throughout the experimental periods. CONCLUSIONS.The new SCLs released the antibiotics over several days, and showed improved penetration into the eye, along with prevention of bacterial proliferation.

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Clinical performance of daily disposable soft contact lenses using sustained release technology

Cited by 106 publications

References 22 publications

Fabrication and characterization of contact lenses bearing surface‐immobilized layers of intact liposomes

Fabrication and characterization of contact lenses bearing surface‐immobilized layers of intact liposomes

Recent Advances in Ocular Drug Delivery Systems

Development and Efficacy of a Drug-Releasing Soft Contact Lens

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