Clinical periodontal status and inflammatory cytokines in gestational diabetes mellitus

Özçaka, Özgün; Ceyhan-Öztürk, Banu; Gümüş, Pınar; Akcalı, Aliye; Nalbantsoy, Ayşe; Buduneli, Nurcan

doi:10.1016/j.archoralbio.2016.08.012

Cited by 17 publications

(12 citation statements)

References 51 publications

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“…Özçaka and cols. observed higher periodontitis rates, plaque accumulation and BOP in patients with GDM compared to those without GDM (33). As aforementioned, there was no intergroup difference for maternal age in this present study.…”

Section: Outcomes Of Gdm and Periodontitissupporting

confidence: 61%

Association among gestational diabetes mellitus, periodontitis and prematurity: a cross-sectional study

Damante

Foratori‐Junior

Cunha

et al. 2022

Archives of Endocrinology and Metabolism

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Objective: Gestational diabetes mellitus (GDM) causes maternal and infant morbidity. Periodontitis is associated with adverse pregnancy outcomes. The aim of this study was to evaluate periodontal status, prematurity and associated factors in pregnant women with and without GDM. Subjects and methods: This observational cross-sectional study included 80 pregnant women with GDM (G1 = 40) and without GDM (G2 = 40). Demographic and socioeconomic status, systemic and periodontal health condition, prematurity and newborns' birth weight were analyzed. For bivariate analysis, Mann-Whitney U-test, t test and Chi-squared test were used. Binary logistic regression analyzed independent variables for periodontitis and prematurity (p < 0.05). Results: Patients from G1 presented lower socioeconomic status, higher weight and body mass index (BMI). Prematurity (G1 = 27.5%; G2 = 2.5%; p < 0.05) and severe periodontitis percentages (G1 = 22.5%; G2 = 0; p = 0.001) were higher in G1 than in G2. Logistic regression analysis showed that household monthly income (OR = 0.65; 95% CI 0.48 -0.86; p = 0.003) and maternal BMI (adjusted OR = 1.12; 95% CI 1.01-1.25; p = 0.028) were significant predictors of periodontitis during the third trimester of pregnancy. Presence of GDM remained in the final logistic model related to prematurity (adjusted OR = 14.79; 95% CI 1.80-121.13; p = 0.012). Conclusions: Pregnant women with GDM presented higher severity of periodontitis, lower socioeconomic status, higher overweight/obesity and a 10-fold higher risk of prematurity. Socioeconomic-cultural status and BMI were significant predictors for periodontitis, and GDM was a predictor to prematurity.

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Section: Outcomes Of Gdm and Periodontitissupporting

confidence: 61%

Association among gestational diabetes mellitus, periodontitis and prematurity: a cross-sectional study

Damante

Foratori‐Junior

Cunha

et al. 2022

Archives of Endocrinology and Metabolism

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“…In addition, the associations between insulin resistance, low-grade inflammation and type-I diabetes mellitus have been investigated in a previous study (42). Changes in inflammatory/necrosis biomarkers following exercise treatment have been analyzed in the progression of diabetes mellitus (43,44). However, to the best of our knowledge, the molecular mechanisms involved in diabetes mellitus have not been clearly elaborated during previous studies.…”

Section: Discussionmentioning

confidence: 99%

Aerobic exercise regulates blood lipid and insulin resistance via the toll‑like receptor 4‑mediated extracellular signal‑regulated kinases/AMP‑activated protein kinases signaling pathway

Wang

et al. 2018

Mol Med Report

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Diabetes mellitus is a complicated metabolic disease with symptoms of hyperglycemia, insulin resistance, chronic damage and dysfunction of tissues, and metabolic syndrome for insufficient insulin production. Evidence has indicated that exercise treatments are essential in the progression of type‑ІІ diabetes mellitus, and affect insulin resistance and activity of islet β‑cells. In the present study, the efficacy and signaling mechanism of aerobic exercise on blood lipids and insulin resistance were investigated in the progression of type‑ІІ diabetes mellitus. Body weight, glucose metabolism and insulin serum levels were investigated in mouse models of type‑ІІ diabetes mellitus following experienced aerobic exercise. Expression levels of inflammatory factors, interleukin (IL)‑6, high‑sensitivity C‑reactive protein, tumor necrosis factor‑α and leucocyte differentiation antigens, soluble CD40 ligand in the serum were analyzed in the experimental mice. In addition, expression levels of toll‑like receptor 4 (TLR‑4) were analyzed in the liver cells of experimental mice. Changes of oxidative stress indicators, including reactive oxygen species, superoxide dismutase, glutathione and catalase were examined in the liver cells of experimental mice treated by aerobic exercise. Expression levels and activity of extracellular signal‑regulated kinases (ERK) and AMP‑activated protein kinase (AMPK) signaling pathways were investigated in the liver cells of mouse models of type‑ІІ diabetes mellitus after undergoing aerobic exercise. Aerobic exercise decreased the expression levels of inflammatory factors in the serum of mouse models of type‑ІІ diabetes mellitus. The results indicated that aerobic exercise downregulated oxidative stress indicators in liver cells from mouse models of type‑ІІ diabetes mellitus. In addition, the ERK and AMPK signaling pathways were inactivated by aerobic exercise in liver cells in mouse models of type‑ІІ diabetes mellitus. The activity of ERK and AMPK, and the function of islet β‑cells were observed to be improved in experimental mice treated with aerobic exercise. Furthermore, blood lipid metabolism and insulin resistance were improved by treatment with aerobic exercise. Body weight and glucose concentration of serology was markedly improved in mouse models of type‑ІІ diabetes mellitus. Furthermore, TLR‑4 inhibition markedly promoted ERK and AMPK expression levels and activity. Thus, these results indicate that aerobic exercise may improve blood lipid metabolism, insulin resistance and glucose plasma concentration in mouse models of type‑ІІ diabetes mellitus. Thus indicating aerobic exercise is beneficial for improvement of blood lipid and insulin resistance via the TLR‑4‑mediated ERK/AMPK signaling pathway in the progression of type‑ІІ diabetes mellitus.

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“…Since it is well-understood that IL-38 is an anti-inflammatory cytokine, increased IL-38 in GDM probably contributes to the suppression of the highly inflamed placenta and umbilical cord during the GDM condition, which is in line with significantly upregulated proinflammatory cytokines (IL-6 and TNF) in the GDM placenta (45), and the higher levels of systemic and local proinflammatory cytokines in the diabetic condition (12). Although upregulated IL-38 has some suppressive effects under normal conditions, that may be a consequence of mild uncontrolled hyperglycaemia (52), such an anti-inflammatory effect is likely insufficient for quenching the local environment during the GDM condition in susceptible subjects (1,2,9). Thus, it is fundamentally important to strictly control the blood glucose level by all means to minimize potential and irreversible adverse consequence(s).…”

Section: Il-38 In Obstetricsmentioning

confidence: 83%

The Role of IL-37 and IL-38 in Obstetrics Abnormalities

Wang

2021

Front. Med.

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There are two fairly common complications during pregnancy, i.e., gestational diabetes mellitus (GDM) and pre-eclampsia, which are independent, but are also closely linked in prevalence in pregnant women, with potential serious adverse consequences. IL-37 and IL-38, which belong to the IL-1 superfamily, participate in anti-inflammatory responses. Dysregulation of IL-37 and IL-38 has been observed in many auto-immune diseases. IL-37 is substantially reduced in the umbilical cords and placentas of GDM subjects, but IL-37 is significantly induced in the placentas of pre-eclampsia patients, suggesting there are differential regulatory roles of IL-37 in obstetrics, despite IL-37 being an anti-inflammatory mediator. Furthermore, IL-38 is substantially increased in the umbilical cords and placentas of GDM subjects, but minimal difference is observed in the placentas from pre-eclampsia patients. These data imply that IL-38 is also regulated independently within the diseased placentas. This review provides some insight for both basic scientists and medical practitioners to manage these patients effectively.

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Clinical periodontal status and inflammatory cytokines in gestational diabetes mellitus

Cited by 17 publications

References 51 publications

Association among gestational diabetes mellitus, periodontitis and prematurity: a cross-sectional study

Association among gestational diabetes mellitus, periodontitis and prematurity: a cross-sectional study

Aerobic exercise regulates blood lipid and insulin resistance via the toll‑like receptor 4‑mediated extracellular signal‑regulated kinases/AMP‑activated protein kinases signaling pathway

The Role of IL-37 and IL-38 in Obstetrics Abnormalities

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