Encyclopedia of Drug Metabolism and Interactions 2012
DOI: 10.1002/9780470921920.edm136
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Clinical Pharmacology in Drug Labeling. The Impact of Drug Metabolism and Clinical Pharmacology on Recommended Dose of Drugs

Abstract: Drugs have extensive investigation of clinical pharmacology during development, leading to comprehensive drug labels. However, modification of the dose of a drug in different metabolic states or in the presence of concomitant disease is not clearly labeled. Most drugs seem robust enough to be used with minimal dose modification.

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