2003
DOI: 10.1016/s0891-5520(02)00068-5
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Clinical pharmacology of antifungal compounds

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Cited by 148 publications
(102 citation statements)
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“…In contrast, amphotericin B at inhibitory concentrations almost completely suppressed metabolic activity at the 6-or 8-h time points for all isolates. This differential effect on the early metabolic activity of Zygomycetes was probably the result of different mechanisms of action of the azoles and polyenes against these molds (9) and necessitated the use of cutoff levels for the azole agents different than those for amphotericin B in the early XTT assays (Table 2).…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, amphotericin B at inhibitory concentrations almost completely suppressed metabolic activity at the 6-or 8-h time points for all isolates. This differential effect on the early metabolic activity of Zygomycetes was probably the result of different mechanisms of action of the azoles and polyenes against these molds (9) and necessitated the use of cutoff levels for the azole agents different than those for amphotericin B in the early XTT assays (Table 2).…”
Section: Discussionmentioning
confidence: 99%
“…Fluconazole is renally excreted, with approximately 80% recovered in the urine as active, unchanged drug. Currently used dosages span the range of 50 mg/day to as high as 2 g/day; however, the standard dose in adults is 400 to 800 mg/day and in children is 6 to 12 mg/kg (of body weight)/day (1,26). Dosages of 100 mg/day (1.5 mg/kg/day) produce peak serum drug levels of ϳ6.7 g/ml, 400 mg/day (6 mg/kg/day) produces peak levels of 20 to 30 g/ml, and the linear pharmacokinetics of fluconazole would predict peak serum levels of 40 to 60 g/ml at a dosage of 800 mg/day (12 mg/kg/day) (25,84).…”
Section: Pk and Pd Considerationsmentioning
confidence: 99%
“…Several small studies have found similar efficacy of azoles compared to amphotericin B for treatment of preterm infants with fungal sepsis (118,171,221,489). Of the azoles, fluconazole has undergone the most extensive study in VLBW infants.…”
Section: Vol 17 2004 Infections In Very-low-birth-weight Infants 661mentioning
confidence: 99%