Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs

KuKanich, Butch; Bidgood, T. L.; Knesl, Oliver

doi:10.1111/j.1467-2995.2011.00675.x

Cited by 145 publications

(149 citation statements)

References 124 publications

(347 reference statements)

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“…However, studies have shown that COX-1 is present in conjunction with COX-2 at sites of inflammation, while COX-2 can be expressed constitutively 4 in certain areas of the kidney, brain and endothelial cells for normal physiological functions 5 .…”

Section: Most Of Nsaids Collateral Effects Are Attributed Tomentioning

confidence: 99%

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

et al. 2013

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PURPOSE:To evaluate the renal function in healthy dogs submitted to nonselective and preferential COX-2 nonsteroidal antiinflammatory drug (NSAID) therapy. METHODS:Twenty four healthy dogs were distributed into four groups (G) (n=6): ketoprofenG -treated with ketoprofen; nimesulideG -treated with nimesulid; meloxicanG -treated with meloxican; and etodolacG -treated with etodolaco. All the dogs received the NSAIDs for 10 days by oral route. Physical examination and renal function (urinalysis, urinary sodium and gamma-glutamyl transpeptidase (GGT), serum urea, creatinine, potassium and sodium, and endogenous creatinine clearance) were evaluated before, after five and ten days (T0, T5 and T10) of the treatment in all groups. RESULTS:Changes were observed in urinalysis, with a significant increase in renal cells in the urine at T5 and T10 in nimesulideG.Significant reduction in urinary sodium in nimesulideG at T5 was observed. The clearance values were lower in ketoprofenG at T10. CONCLUSIONS:Meloxicam and etodolac were the drugs that have proven to be safer for short-term therapy in healthy dogs in relation to renal function. NSAIDs ketoprofen and nimesulide should be used judiciously in dogs with renal dysfunction, since there are promoted changes in renal function.

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Section: Most Of Nsaids Collateral Effects Are Attributed Tomentioning

confidence: 99%

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

et al. 2013

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“…In this study, renal function was monitored with monthly evaluation of blood urea nitrogen and creatinine, to detect early signs of renal impairment. COX selectivity is related only to the potential to reduce gastrointestinal (GI) side effects in healthy tissues and there is no association with renal or hepatic adverse effects, nor with effects in altered GI tract (KUKANICH et al, 2012). Side effects seen in two patients in this study are probably related to preexisting gastrointestinal disease, worsened with the usage of NSAID.…”

Section: Palavras-chavementioning

confidence: 78%

Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs

et al. 2016

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“…Their fever relieving efect has been well documented since their discovery and they have proven efective over the years in controlling pain and inlammatory conditions. It is particularly efective in acute and chronic orthopedic pain (osteoarthritis, ankylosing spondylitis, and rheumatoid arthritis) and postsurgical pain [4]. While these represent the traditional uses of NSAIDs, studies have pointed to their potential in Alzheimer's [5], cancer [6], and Parkinson's disease [7].…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs

Osafo¹,

Agyare²,

Obiri³

et al. 2017

Nonsteroidal Anti-Inflammatory Drugs

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The use of nonsteroidal anti-inlammatory drugs (NSAIDs) dates back to thousands of years when man used natural sources of these agents in a lot of pain and inlammatory conditions. The tone for modern day discovery and use of NSAIDs was set with the discovery of aspirin. Today in addition to aspirin, a host of other NSAIDs of varying potency and eicacy is employed in the management of pain and inlammatory conditions. This chapter looks with key interest in the existing and evolving role of NSAIDs in therapeutics with emphasis on the current insights into their mechanism of action and side efect proiles associated with its use in pain and inlammation as well as its potential therapeutic beneits in cancer chemotherapy.

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Clinical pharmacology of nonsteroidal anti-inflammatory drugs in dogs

Cited by 145 publications

References 124 publications

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

Nonsteroidal anti-inflammatory therapy: changes on renal function of healthy dogs

Cyclooxygenase-2 expression in epithelial neoplasms and its relevance as a targeted therapy in dogs

Mechanism of Action of Nonsteroidal Anti-Inflammatory Drugs

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