Clinical pharmacology of vasodilating drugs

Abstract

The human pharmacology of oasodilaiors and their total cardiovascular effect are reviewed. Emphasis is placed on the peripheral circulation through skin and muscle; cardiac output, blood pressure, and circulation through the lungs, kidneys, lioer, eyes, and splanchnic areas are also surveyed. Objective methods for studying the oasodilators in man are described in sufficient detail to make objective eoaluation understandable. Laboratory studies are examined in the light of clinical observations, and the combined information seroes as a basis for establishing indications for the use of these drugs.

Blood Flow Measurements in Response To Bamethane Sulfate in Man

“…As the following figures (figs. 1 and 2) show, there is a relationship between initial perfusion value and increase relative to such initial value.…”

“…1,2 However, even in various parts of a single organ the vascular response can differ considerably. Physiologically produced substances, too, have a varying effect in different vascular beds.…”